孤独症谱系障碍儿童肠道菌群变化及作用机制

祖姆热提·伊敏; 热娜·买买提; 王敏囡

doi:10.11852/zgetbjzz2024-0960

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中国儿童保健杂志 ›› 2025, Vol. 33 ›› Issue (6) : 638-642. DOI: 10.11852/zgetbjzz2024-0960

综述

孤独症谱系障碍儿童肠道菌群变化及作用机制

祖姆热提·伊敏, 热娜·买买提, 王敏囡

作者信息 +

Changes and mechanisms of gut microbiota in children with autism spectrum disorder

ZUMURETI·Yimin, RENA·Maimaiti, WANG Minnan

Author information +

文章历史 +

摘要

孤独症谱系障碍(ASD)是以社交沟通障碍、重复刻板行为、兴趣狭窄为特点的神经发育障碍性疾病。最近研究发现,ASD儿童肠道菌群的组成成分及菌群丰度发生改变,而肠道菌群的改变可通过脑-肠-菌轴影响儿童的脑功能发育,导致行为发育障碍。目前不同的研究所报道的ASD患儿肠道菌群多样性、分类水平丰度的改变以及作用机制存在显著差异。因此,本文对ASD儿童中最常见的肠道菌群的改变情况以及在ASD儿童中的作用机制进行综述,为ASD与肠道菌群之间的相关性研究提供依据。

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by difficulties in social communication, restrictive and repetitive behaviors, narrow interests.Recent studies have found that the composition and abundance of gut microbiota are changed in children with ASD, which affect the brain functional development of children through the "microbiota-gut-brain axis", resulting in behavioral development disorder.Currently, there are significant differences in the reported changes in gut microbiome diversity, taxonomic level abundance, and mechanisms of action among children with ASD in different research institutes.Therefore, this article reviews the changes and mechanism of the most common gut microbiota in children with ASD, in order to provide a basis for further study.

导出引用

祖姆热提·伊敏, 热娜·买买提, 王敏囡. 孤独症谱系障碍儿童肠道菌群变化及作用机制[J]. 中国儿童保健杂志. 2025, 33(6): 638-642 https://doi.org/10.11852/zgetbjzz2024-0960

ZUMURETI·Yimin, RENA·Maimaiti, WANG Minnan. Changes and mechanisms of gut microbiota in children with autism spectrum disorder[J]. Chinese Journal of Child Health Care. 2025, 33(6): 638-642 https://doi.org/10.11852/zgetbjzz2024-0960

中图分类号： R179

参考文献

[1] Salari N, Rasoulpoor S, Rasoulpoor S, et al.The global prevalence of autism spectrum disorder: A comprehensive systematic review and Meta-analysis[J].Ital J Pediatr,2022, 48(1):112-128.
[2] Hirota T, King BH.Autism spectrum disorder: A Review[J].JAMA,2023, 329(2):157-168.
[3] Iglesias-Vázquez L, Van Ginkel Riba G, Arija V, et al.Composition of gut microbiota in children with autism spectrum disorder: A systematic review and Meta-analysis[J].Nutrients,2020, 12(3):1-21.
[4] Korteniemi J, Karlsson L, Aatsinki A.Systematic review: Autism spectrum disorder and the gut microbiota[J].Focus (Am Psychiatr Publ),2024, 22(2):242-251.
[5] Oh D, Cheon KA.Alteration of gut microbiota in autism spectrum disorder: An overview[J].Soa Chongsonyon Chongsin Uihak.2020, 31(3):131-145.
[6] Neubauer J, Kaiser A, Hohmann S.Gut microbiota and autism spectrum disorders: An overview of correlations and potential implications for therapeutic interventions[J].Z Kinder Jugendpsychiatr Psychother,2024;52(3):151-165.
[7] Ding X, Xu Y, Zhang X, et al.Gut microbiota changes in patients with autism spectrum disorder[J].J Psychiatr Res,2020, 129(2020):149-159.
[8] Lungba RM, Khan SZA, Ajibawo-Aganbi U, et al.The role of the gut microbiota and the immune system in the development of autism[J].Cureus,2020, 12(10):1-5.
[9] Xue Y, An S, Qiu W, et al.Exercise changes gut microbiota: A new idea to explain that exercise improves autism[J].Int J Sports Med,2023, 44(7):473-483.
[10] Mehra A, Arora G, Sahni G, et al.Gut microbiota and autism spectrum disorder: From pathogenesis to potential therapeutic perspectives[J].J Tradit Complement Med,2022, 13(2):135-149.
[11] Socała K, Doboszewska U, Szopa A, et al.The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders[J].Pharmacol Res,2021,172(10):1-38.
[12] Dargenio VN, Dargenio C, Castellaneta S, et al.Intestinal barrier dysfunction and microbiota-gut-brain axis: possible implications in the pathogenesis and treatment of autism spectrum disorder[J].Nutrients,2023, 15(7):1-27.
[13] Posar A, Visconti P.Gut microbiota alterations in autism spectrum disorder[J].Turk Arch Pediatr.2024, 59(5):506-507.
[14] Poupard L, Page G, Thoreau V, et al.Relationships between gut microbiota and autism spectrum disorders: Development and treatment[J].Clin Psychopharmacol Neurosci,2024, 22(4):554-564.
[15] Wang Q, Yang Q, Liu X.The microbiota-gut-brain axis and neurodevelopmental disorders[J].Protein Cell,2023, 14(10):762-775.
[16] Peralta-Marzal LN, Prince N, Bajic D, et al.The impact of gut microbiota-derived metabolites in autism spectrum disorders[J].Int J Mol Sci,2021, 22(18):1-25.
[17] Gonçalves CL, Doifode T, Rezende VL, et al.The many faces of microbiota-gut-brain axis in autism spectrum disorder[J].Life Sci,2024, 337(1):1-26.
[18] Liu J, Gao Z, Liu C, et al.Alteration of gut microbiota: New strategy for treating autism spectrum disorder[J].Front Cell Dev Biol,2022, 3(10):1-17.
[19] Hu T, Dong Y, He C, et al.The gut microbiota and oxidative stress in autism spectrum disorders (ASD)[J].Oxid Med Cell Longev,2020, 20(1):13-26.
[20] Chen YC, Lin HY, Chien Y, et al.Altered gut microbiota correlates with behavioral problems but not gastrointestinal symptoms in individuals with autism[J].Brain Behav Immun,2022, 106(11):161-178.
[21] Ni JJ, Xu Q, Yan SS, et al.Gut microbiota and psychiatric disorders: A two-sample mendelian randomization study[J].Front Microbiol,2022, 4(12):1-11.
[22] Carmel J, Ghanayem N, Mayouf R, et al. Bacteroides is increased in an autism cohort and induces autisn-relevant behavioral changes in mice in a sex-dependent manner[J]. NPJ Biofilms Microbiomes, 2023,9(1):103-111.
[23] Ho LKH, Tong VJW, Syn N, et al.Gut microbiota changes in children with autism spectrum disorder: A systematic review[J].Gut Pathog,2020,12(6):1-18.
[24] Dan Z, Mao X, Liu Q, et al.Altered gut microbial profile is associated with abnormal metabolism activity of autism spectrum disorder[J].Gut Microbes,2020, 11(5):1246-1267.
[25] Liu S,Li E,Sun Z,et al.Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder[J].Sci Rep,2020, 9(1): 287-296.
[26] Nápoles-Medina AY, Aguilar-Uscanga BR, Solís-Pacheco JR, et al.Oral administration of lactobacillus inhibits the permeability of blood-brain and gut barriers in a parkinsonism model[J].Behav Neurol,2023, 23(1):1-10.
[27] Mohammad FK, Palukuri MV, Shivakumar S, et al.A computational framework for studying gut-brain axis in autism spectrum disorder[J].Front Physiol,2022, 13(1):1-24.
[28] Wong OWH, Lam AMW, Or BPN, et al.Disentangling the relationship of gut microbiota, functional gastrointestinal disorders and autism: A case-control study on prepubertal Chinese boys[J].Sci Rep,2022, 12(1):1-13.
[29] Levkova M, Chervenkov T, Pancheva R.Genus-level analysis of gut microbiota in children with autism spectrum disorder: A mini review[J].Children (Basel), 2023, 10(7):1-13.
[30] Zou R, Xu F, Wang Y, et al.Changes in the gut microbiota of children with autism spectrum disorder[J].Autism Res,2020, 13(9):1614-1625.