目的 明确儿童青少年人群中血尿酸与代谢综合征(MetS)及其组分的影响,为该人群的MetS的预防提供依据。方法 从中国健康与营养调查(CHNS)数据库中获取人口学资料、人体测量和生化指标等。利用Logistic 回归模型评估尿血酸与MetS的关联并利用相加相乘模型来评估年龄、性别和体质量指数(BMI)分别与血尿酸的交互作用对MetS的影响。结果 共计纳入10~17岁儿童青少年591例,其中中心性肥胖占8.8%,高空腹血糖占6.9%,血压升高占12.4%,高甘油三酯占25.0%,低高密度脂蛋白占9.1%。高尿酸血症(HUA)均是中国标准和Cook标准MetS的危险因素(中国标准MetS:OR＝18.79,95%CI:3.08~114.66;Cook标准MetS:OR＝7.53,95%CI:1.97~28.77),且与MetS组分中心性肥胖、高甘油三酯、低高密度脂蛋白之间均存在显著的正向关联。分组研究发现,男性组、10~12岁年龄组和标准体重组中HUA与MetS及其组分中心性肥胖和高甘油三酯的关联更为显著。结论 儿童青少年HUA与MetS患病风险密切相关,主要体现在腹型肥胖、高甘油三酯和低高密度脂蛋白表型上,应通过定期监测儿童青少年血尿酸水平,重视防范该群体HUA的发生,对降低MetS及其心血管疾病的发生发展具有重要意义。
Abstract
Objective To elucidate the impact of serum uric acid (SUA) on metabolic syndrome (MetS) and its components in children and adolescents, in order to provide a basis for the prevention of MetS in this population. Methods Demographic data, anthropometric measurements, and biochemical indicators were obtained from the China Health and Nutrition Survey (CHNS) database. Logistic regression models were used to assess the association between SUA and MetS. Additive and multiplicative models were employed to evaluate the interaction effects of age, sex, and body mass index (BMI) with SUA on MetS. Results A total of 591 children and adolescents aged 10 - 17 years were included, of whom 8.8% had central obesity, 6.9% had elevated fasting blood glucose, 12.4% had elevated blood pressure, 25.0% had hypertriglyceridemia (high TG), and 9.1% had low high-density lipoprotein (HDL). Hyperuricemia (HUA) was identified as a risk factor for MetS based on both Chinese criteria (OR=18.79,95%CI: 3.08 - 114.66) and Cook criteria (OR=7.53, 95%CI: 1.97 - 28.77). HUA was also significantly positively associated with MetS components, including central obesity, high TG, and low HDL. Subgroup analysis revealed that the associations between HUA and MetS, as well as its components (central obesity and hypertriglyceridemia), were more pronounced in males, the 10 - 12 age group, and the normal-weight group. Conclusion HUA is closely associated with the risk of MetS in children and adolescents, particularly in phenotypes characterized by central obesity, hypertriglyceridemia, and low HDL. These findings suggest that regular monitoring of SUA levels in children and adolescents, along with efforts to prevent HUA, is crucial for reducing the incidence and progression of MetS and related cardiovascular diseases.
关键词
代谢综合征 /
高尿酸血症 /
中国健康与营养调查 /
儿童青少年
Key words
metabolic syndrome /
hypericemia /
China Health and Nutrition Survey /
children and adolescents
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基金
国家重点研发计划资助项目(2021YFC2701900,2021YFC2701903)
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