目的 了解不同胎龄早期男性新生儿血清促卵泡刺激素(FSH)、促黄体生成素(LH)、睾酮(T)水平及其与阴茎长度、睾丸容积的关系,为男性性发育不良早期干预时机的选择及生育力保护提供依据。方法 选取2022年1月—2023年2月河南科技大学第一附属医院新生儿病房的胎龄≥32周且病情平稳的50例早期男性新生儿为研究对象,按照胎龄将其分为早产儿组与足月儿组,测量阴茎长度及睾丸容积,采用化学发光免疫法测定血清FSH、LH、T水平,分析阴茎长度、睾丸容积与血清FSH、LH、T的关系。结果 早产儿组与足月儿组血清FSH、LH、T水平比较,差异无统计学意义(P＞0.05)。两组新生儿血清FSH、LH水平与阴茎长度均呈正相关(早产儿组r=0.466、0.632,P＜0.05,足月儿组r=0.449、0.501,P＜0.05),患儿血清T水平与阴茎长度及睾丸容积均无相关性(P＞0.05)。足月儿组血清FSH、两组血清LH水平与睾丸容积均呈正相关(r=0.435、0.578、0.433,P＜0.05)。结论 血清 FSH、LH、T水平与胎龄无关。FSH、LH对阴茎的生长发育有促进作用,LH对睾丸容积的增长具有促进作用,FSH仅在足月儿中对睾丸容积的增长具有促进作用。
Abstract
Objective To investigate the serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) in early male neonates of different gestational ages and their relationships with penis length and testicular volume, so as to provide basis for the timing of early intervention in male sexual underdevelopment and fertility preservation. Methods From January 2022 to February 2023, 50 clinically stable early male neonates with a gestational age of ≥32 weeks admitted to the neonatal ward of the First Affiliated Hospital of Henan University of Science and Technology were selected into this study, and were divided into a preterm group and a term group based on their gestational age. Penis length and testicular volume were measured, and serum levels of FSH, LH, and T were tested using chemiluminescent immunoassay. The correlation of penis length and testicular volume with serum levels of FSH, LH, and T were analyzed. Results No significant differences were observed in serum levels of FSH, LH, and T between the preterm and term groups (P>0.05). Serum FSH and LH levels were positively correlated with penis length in both groups (preterm group: r=0.466, 0.632, P<0.05; term group: r=0.449, 0.501, P<0.05), while serum T levels were not significantly correlated with penis lengthand testicular volume in either group (P>0.05). Serum FSH level in the term group and serum LH level in both groups were positively correlated with (r=0.435, 0.578, 0.433, P<0.05). Conclusions Serum levels of FSH, LH, and T are not related to gestational age. FSH and LH promote the growth and development of the penis, and LH promotes testicular volume growth. Additionally, FSH is found to promote testicular volume growth only in term infants.
关键词
早期新生儿 /
促性腺激素 /
性激素 /
阴茎 /
睾丸
Key words
early newborns /
gonadotropins /
sex hormones /
penile /
testicular
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基金
河南省级科技研发计划联合基金项目(225200810054);河南省科技攻关计划项目(212102310780)
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