脂质组学分析方法在儿童健康与疾病中的应用

陈宜人; 吴丽君; 陈芳芳

doi:10.11852/zgetbjzz2022-1300

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中国儿童保健杂志 ›› 2023, Vol. 31 ›› Issue (10) : 1091-1095. DOI: 10.11852/zgetbjzz2022-1300

综述

脂质组学分析方法在儿童健康与疾病中的应用

陈宜人, 吴丽君, 陈芳芳

作者信息 +

Advances in the application of lipidomics analysis method in children's health and diseases

CHEN Yiren, WU Lijun, CHEN Fangfang

Author information +

文章历史 +

摘要

脂质组学分析方法是对脂质类代谢物及相互作用的分子进行全面系统的分析与鉴定,可以揭示脂质及脂质代谢与细胞、器官乃至机体的生理或病理过程的联系。脂质组学分析方法发展至今,已不止局限于对已临床确诊的患者进行病理学方面的辅助验证,而是逐渐发展为前瞻性预测疾病发生及监测疾病进展的一种手段。本文主要总结了脂质组学分析方法在儿童健康与疾病中的应用进展。

Abstract

Lipidomics analysis method is a comprehensive and systematic analysis and identification of lipid metabolites and interacting molecules, which can reveal the relationship between lipid metabolism and physiological or pathological processes of cells, organs and even the body. The development of lipidomics analysis method has not only been limited to the auxiliary verification of pathology in clinically diagnosed patients, but has gradually developed into a means of prospective prediction of disease occurrence and monitoring of disease progression. This article mainly summarizes the application progress of lipidomics analysis method in children's health and disease.

导出引用

陈宜人, 吴丽君, 陈芳芳. 脂质组学分析方法在儿童健康与疾病中的应用[J]. 中国儿童保健杂志. 2023, 31(10): 1091-1095 https://doi.org/10.11852/zgetbjzz2022-1300

CHEN Yiren, WU Lijun, CHEN Fangfang. Advances in the application of lipidomics analysis method in children's health and diseases[J]. Chinese Journal of Child Health Care. 2023, 31(10): 1091-1095 https://doi.org/10.11852/zgetbjzz2022-1300

中图分类号： R72

参考文献

[1] van der Hee B, Wells JM. Microbial regulation of host physiology by short-chain fatty acids[J]. Trends Microbiol, 2021, 29 (8): 700-712.
[2] Han X, Gross RW. Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry:A bridge to lipidomics[J]. J Lipid Res, 2003, 44 (6): 1071-1079.
[3] 田琪,李肖飞,冯晔,等. 脂质组学技术在疾病诊断中的研究进展[J]. 中医药导报, 2019, 25(21): 83-86.
Tian Q,Li XF,Feng Y,et al. Research progress of lipidomics in disease diagnosis[J]. Guid J Tradit Chin Med Pharm,2019,25(21):83-86.(in Chinese)
[4] 迟学彭,于冬梅,琚腊红,等. 儿童青少年糖尿病患病现况及变化趋势研究[J]. 当代医学, 2019, 25(11): 190-192.
Chi XP,Yu DM,Ju LH,et al. Study on current situation and changing trend of diabetes in children and adolescents[J]. Contemp Med, 2019, 25(11): 190-192.(in Chinese)
[5] 赵光明,刘红艳.中国儿童青少年超重肥胖流行趋势及其影响因素[J]. 世界最新医学信息文摘,2021,21(44):63-66.
Zhao GM,Liu HY. Prevalence of overweight and obesity in Chinese children and adolescents and its influencing factors[J]. World Latest Medicine Information, 2021, 21 (44): 63-66.(in Chinese)
[6] Heindel JJ,Balbus J, Birnbaum L,et al. Developmentalorigins of health and disease: Integrating environmental influences[J]. Endocrinology, 2015, 156(10): 3416-3421.
[7] Kofeler HC, Ahrends R, Baker ES,et al. Recommendations for good practice in MS-based lipidomics[J]. J Lipid Res, 2021, 62:100138.
[8] Han X, Gross RW. Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples[J]. Mass Spectrom Rev, 2005, 24 (3): 367-412.
[9] Mahmud I, Kabir M, Haque R,et al. Decoding themetabolome and lipidome of child malnutrition by mass spectrometric techniques: Present status and future perspectives[J]. Anal Chem, 2019, 91 (23): 14784-14791.
[10] Kuerschner L, Thiele C. Tracinglipid metabolism by alkyne lipids and mass spectrometry: The state of the art[J]. Front Mol Biosci, 2022, 9: 880559.
[11] Chaurasia B, Summers SA. Ceramides inmetabolism: Key lipotoxic players[J]. Annu Rev Physiol, 2021, 83: 303-330.
[12] Leon-Aguilar LF, Croyal M, Ferchaud-Roucher V,et al. Maternal obesity leads to long-term altered levels of plasma ceramides in the offspring as revealed by a longitudinal lipidomic study in children[J]. Int J Obes (Lond), 2019, 43 (6): 1231-1243.
[13] Daraki V, Roumeliotaki T, Koutra K, et al. Effect of parental obesity and gestational diabetes on child neuropsychological and behavioral development at 4 years of age: The Rhea mother-child cohort, Crete, Greece[J]. Eur Child Adolesc Psychiatry, 2017, 26(6): 703-714.
[14] LaBarre JL, Miller AL, Bauer KW,et al. Early life stress exposure associated with reduced polyunsaturated-containing lipids in low-income children[J]. Pediatr Res, 2021, 89 (5): 1310-1315.
[15] Chen CS, Kuo TC, Kuo HC,et al. Lipidomics of children and adolescents exposed to multiple industrial pollutants[J]. Environ Res, 2021, 201: 111448.
[16] McGlinchey A, Sinioja T, Lamichhane S,et al. Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes[J]. Environ Int, 2020, 143: 105935.
[17] Jones PR, Rajalahti T, Resaland GK,et al. Associations of physical activity and sedentary time with lipoprotein subclasses in Norwegian schoolchildren: The Active Smarter Kids (ASK) study[J]. Atherosclerosis, 2019, 288: 186-193.
[18] Magge SN, Goodman E, Armstrong SC. Themetabolic syndrome in children and adolescents: Shifting the focus to cardiometabolic risk factor clustering[J]. Pediatrics, 2017, 140 (2): e20171603.
[19] Anjos S, Feiteira E, Cerveira F,et al. Lipidomicsreveals similar changes in serum phospholipid signatures of overweight and obese pediatric subjects[J]. J Proteome Res, 2019, 18 (8): 3174-3183.
[20] Szczerbinski L, Wojciechowska G, Olichwier A,et al. Untargeted metabolomics analysis of the serum metabolic signature of childhood obesity[J]. Nutrients, 2022, 14 (1): doi: 10.3390/nu14010214.
[21] Tsatsoulis A, Paschou SA. Metabolicallyhealthy obesity: Criteria, epidemiology, controversies, and consequences[J]. Curr Obes Rep, 2020, 9(2):109-120.
[22] Castillo EC, Elizondo-Montemayor L, Hernandez-Brenes C,et al. Integrative analysis of lipid profiles in plasma allows cardiometabolic risk factor clustering in children with metabolically unhealthy obesity[J]. Oxid Med Cell Longev, 2020, 2020 2935278.
[23] Djuricic I, Calder PC. Beneficialoutcomes of Omega-6 and Omega-3 polyunsaturated fatty acids on human health: An update for 2021[J]. Nutrients, 2021,13 (7): 2421.
[24] Innes JK, Calder PC. Omega-6 fatty acids and inflammation[J]. Prostaglandins Leukot Essent Fatty Acids, 2018, 132: 41-48.
[25] Sung KC, Park HY, Kim MJ,et al. Metabolic markers associated with insulin resistance predict type 2 diabetes in Koreans with normal blood pressure or prehypertension[J]. Cardiovasc Diabetol, 2016, 15: 47.
[26] Dabelea D, Stafford JM, Mayer-Davis EJ,et al. Association of type 1 diabetes vs type 2 diabetes diagnosed during childhood and adolescence with complications during teenage years and young adulthood[J]. JAMA, 2017, 317 (8): 825-835.
[27] Lopez X, Goldfine AB, Holland WL,et al. Plasma ceramides are elevated in female children and adolescents with type 2 diabetes[J]. J Pediatr Endocrinol Metab, 2013, 26 (9-10): 995-998.
[28] Majumdar I,Mastrandrea LD. Serum sphingolipids and inflammatory mediators in adolescents at risk for metabolic syndrome[J]. Endocrine, 2012, 41 (3): 442-449.
[29] Vajro P, Lenta S, Socha P,et al. Diagnosis of nonalcoholic fatty liver disease in children and adolescents: Position paper of the ESPGHAN Hepatology Committee[J]. J Pediatr Gastroenterol Nutr, 2012, 54 (5): 700-713.
[30] Wasilewska N, Bobrus-Chociej A, Harasim-Symbor E,et al. Increased serum concentration of ceramides in obese children with nonalcoholic fatty liver disease[J]. Lipids Health Dis, 2018, 17 (1): 216.
[31] Kurek K, Piotrowska DM, Wiesiolek-Kurek P,et al. Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease[J]. Liver Int, 2014, 34 (7): 1074-1083.
[32] Draijer LG, Froon-Torenstra D, van Weeghel M,et al. Lipidomics in nonalcoholic fatty liver disease: Exploring serum lipids as biomarkers for pediatric nonalcoholic fatty liver disease[J]. J Pediatr Gastroenterol Nutr, 2020, 71 (4): 433-439.
[33] Wang ZH, Zheng KI, Wang XD,et al. LC-MS-based lipidomic analysis in distinguishing patients with nonalcoholic steatohepatitis from nonalcoholic fatty liver[J]. Hepatobiliary Pancreat Dis Int, 2021, 20 (5): 452-459.
[34] Titchenell PM, Lazar MA,Birnbaum MJ. Unraveling the regulation of hepatic metabolism by insulin[J]. Trends Endocrinol Metab, 2017,28(7): 497-505.
[35] Lamichhane S, Ahonen L, Dyrlund TS,et al. Dynamics of plasma lipidome in progression to islet autoimmunity and type 1 diabetes - type 1 diabetes prediction and prevention study (DIPP)[J]. Sci Rep, 2018,8(1):10635.
[36] Lamichhane S, Ahonen L, Dyrlund TS,et al. Cord-blood lipidome in progression to islet autoimmunity and type 1 diabetes[J]. Biomolecules, 2019, 9 (1): doi: 10.3390/biom9010033.
[37] Andersson Svard A, Kaur S, Trost K,et al. Characterization of plasma lipidomics in adolescent subjects with increased risk for type 1 diabetes in the DiPiS cohort[J]. Metabolomics, 2020, 16(10): 109.
[38] 刘贤,林穗方,陈文雄,等. 中国儿童孤独症谱系障碍患病率Meta分析[J]. 中国儿童保健杂志,2018,26(4):402-406.
Liu X,Lin SF,Chen WX,et al. AMeta-analysis of the prevalence of autism spectrum disorders in children in China[J].Chin J Child Health Care, 2018, 26 (4): 402-406.(in Chinese)
[39] 曾海辉,陈妙婷,肖运华,等. 孤独症谱系障碍患儿早期康复治疗的疗效和预后[J].神经病学与神经康复学杂志,2020,16(4):158-164.
Zeng HH,Chen MT,Xiao YH,et al. Efficacy and prognosis of early rehabilitation in children with autism spectrum disorders[J]. Journal of Neurology and Neurorehabilitation, 2020, 16(4):158-164.(in Chinese)
[40] Usui N, Iwata K, Miyachi T,et al. VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction[J]. E Bio Medicine, 2020,58:102917.
[41] El-Ansary AK, Bacha AG, Al-Ayahdi LY. Plasma fatty acids as diagnostic markers in autistic patients from Saudi Arabia[J]. Lipids Health Dis, 2011,10:62.
[42] Erkan E, Zhao X, Setchell K,et al. Distinct urinary lipid profile in children with focal segmental glomerulosclerosis[J]. Pediatr Nephrol, 2016,31(4):581-588.
[43] Scholte BJ, Horati H, Veltman M,et al. Oxidative stress and abnormal bioactive lipids in early cystic fibrosis lung disease[J]. J Cyst Fibros, 2019,18(6):781-789.
[44] Nogal A, Valdes AM, Menni C. The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health[J]. Gut Microbes, 2021, 13 (1): 1-24.
[45] Agus A, Clement K, Sokol H. Gut microbiota-derived metabolites as central regulators in metabolic disorders[J]. Gut, 2021, 70 (6): 1174-1182.