目的 探讨营养支持小组(NST)管理模式对早产儿生长发育及免疫功能的影响,以期为早产儿的早期营养支持提供参考。方法 选取2019年1月—2021年12月杭州市妇产科医院住院治疗的98例早产儿,采用随机数字表法分为观察组49例和对照组49例。观察组实施NST管理模式,对照组实施综合营养支持管理模式,均持续至早产儿纠正月龄6个月。比较观察组和对照组纠正月龄6个月的体质量、身长、头围的增长速度及达追赶性生长率、智力发展指数(MDI)、心理运动发育指数(PDI);比较两组出生后1h内、纠正月龄6个月的免疫球蛋白A(IgA)、免疫球蛋白M(IgM)和免疫球蛋白G(IgG)水平及干预期间常见并发症的发生率。结果 纠正月龄6个月,观察组体质量增长速度、头围增长速度和身长增长速度显著高于对照组(t=6.773、9.859、4.831, P＜0.05);观察组达追赶性生长率、MDI评分和PDI评分等智力发育评分显著高于对照组(χ2=4.947,t=12.572、4.495, P＜0.05);观察组IgA、IgM和IgG明显高于对照组(t=3.062、7.617、9.185,P＜0.05);观察组干预期间喂养不耐受发生率为8.16%,显著低于对照组的26.53%(χ2=5.763, P＜0.05)。结论 NST管理模式可加快早产儿生长发育,提高其免疫功能,具有一定的临床应用价值。
Abstract
Objective To analyze the effects of nutrition support team (NST) management mode on growth development and immune function in premature infants, in order to provide reference for early nutritional support of premature infants. Methods A total of 98 premature infants treated in Hangzhou Obstetrics and Gynecology Hospital were enrolled in this study from January 2019 and December 2021.According to random number table method, infants were divided into observation group (n=49) and control group (n=49).The observation group was given NST management, while the control group received comprehensive nutrition support management.All infants were continuously intervened till 6 months of corrected month age.The growth rates of body mass, length and head circumference, catch-up growth rate, scores of mental development index (MDI) and psycho-motor development index (PDI) after 6 months of corrected age, levels of immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) within 1h after birth and after 6 months of corrected age, as well as incidence of common complications suring intervention were compared between the two groups. Results After 6 months of corrected age, growth rates of body mass, head circumference and length in the observation group were significantly higher than those in the control group (t=6.773, 9.859, 4.831, P<0.05).The catch-up growth rate, scores of MDI and PDI in observation group were significantly higher than those in control group (t=4.947, 12.572, 4.495, P<0.05), and levels of IgA, IgM and IgG were significantly higher than those in control group (t=3.062, 7.617, 9.185, P<0.05).During intervention, the incidence of feeding intolerance in observation group was significantly lower than that in control group (8.16% vs.26.53%, χ2=5.763, P<0.05). Conclusion NST management mode can promote growth development and enhance immune function in premature infants, which has some application value in clinic practice.
关键词
营养支持小组 /
管理模式 /
早产儿 /
生长发育 /
免疫功能
Key words
nutrition support team /
management mode /
premature infants /
growth development /
immune function
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