目的 分析血脂、血清尿酸等心血管代谢指标在不同控制水平哮喘患儿的变化,以探讨哮喘控制水平与心血管代谢危险因素的关系。方法 选取2018年10月—2019年12月河南省儿童医院就诊的88例哮喘患儿为病例组,按哮喘控制水平分为良好控制组和未良好控制组,同时期30例健康体检儿童作为对照组。检测受试者血脂、血清尿酸(sUA)、体重指数(BMI)水平,并对病例组患儿进行肺功能检测。结果 病例组和对照组低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、sUA水平差异无统计学意义(P＞0.05),病例组患儿高密度脂蛋白胆固醇(HDL-C)水平较对照组降低(t=-2.213,P＜0.05),良好控制组患儿HDL-C水平高于未良好控制组(t=2.692,P＜0.05),sUA水平低于未良好控制组(t=-2.430,P＜0.05),良好控制组第1秒用力呼气容积占预计值百分比(FEV1% pred)水平较未良好控制组显著增高(t=9.741,P＜0.05)。未良好控制组哮喘患儿FEV1% pred水平与HDL-C水平呈正相关(r=0.457,P＜0.01),与sUA水平负呈相关(r=-0.671,P＜0.01)。结论 儿童哮喘控制水平与HDL-C、sUA水平有关,HDL-C降低、sUA升高可能是儿童哮喘控制不佳、肺功能较差的危险因素。
Abstract
Objective To analyze the changes of cardiovascular metabolic indicators such as blood lipids and serum uric acid in asthmatic children with different control levels, in order to determine the relationship between asthma control levels and cardiovascular metabolic risk factors. Methods A total of 88 asthmatic children who visited Zhengzhou Children's Hospital from October 2018 to December 2019 were selected as the case group, and were divided into well-controlled group and poorly-controlled group according to the asthma control level. Meanwhile, 30 healthy children were selected as the control group. The blood lipids, serum uric acid (sUA) and body mass index (BMI) levels of the asthmatic children were detected, and the lung function of the children in the case group was tested. Results There was no significant difference in the levels of low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG) and sUA between the case group and the control group (P>0.05). The level of high-density lipoprotein cholesterol (HDL-C) in the case group was significantly lower than that in the control group (t=-2.213,P＜0.05). The HDL-C level in the well-controlled group was significantly higher than that in the poorly-controlled group (t=2.692, P＜0.05), and the sUA level was significantly lower than that in the poorly-controlled group(t=-2.430, P＜0.05). The FEV1% pred level in the well-controlled group was significantly higher than that in the poorly-controlled group (t=9.741, P＜0.05). The FEV1% pred level of asthmatic children in the poorly controlled group was positively correlated with HDL-C level (r=0.457, P＜0.01), and negatively correlated with sUA level (r=-0.671,P＜0.01). Conclusion The control level of asthma in children is related to the levels of HDL-C and sUA, and the decrease of HDL-C and the increase of sUA may be the risk factors for poor control of asthma and poor lung function in children.
关键词
哮喘 /
血脂 /
尿酸 /
儿童
Key words
asthma /
blood lipid /
uric acid /
children
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基金
河南省医学科技攻关计划联合共建项目(LHGJ20190977,LHGJ20210660)
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