儿童与青少年血清维生素D水平与骨折风险相关性研究的Meta分析

叶夕霞; 朱之心; 陈明明; 张雅琴; 周静; 曹文婷

doi:10.11852/zgetbjzz2022-0240

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中国儿童保健杂志 ›› 2023, Vol. 31 ›› Issue (4) : 416-421. DOI: 10.11852/zgetbjzz2022-0240

荟萃分析

儿童与青少年血清维生素D水平与骨折风险相关性研究的Meta分析

叶夕霞¹, 朱之心², 陈明明², 张雅琴¹, 周静², 曹文婷^1,2

作者信息 +

Meta-analysis of the relationship between serum vitamin D level and risk of pediatric fractures

YE Xixia¹, ZHU Zhixin², CHEN Mingming², ZHANG Yaqin¹, ZHOU Jing², CAO Wenting^1,2

Author information +

文章历史 +

摘要

目的系统评价血清维生素D(Vit D)水平与儿童骨折风险的相关性,为儿童骨折的早期预防提供理论依据。方法计算机检索PubMed、EMbase、CNKI、维普中文科技期刊、万方数据知识服务平台数据库,搜集有关血清Vit D含量与儿童骨折风险关联的观察性研究,检索时间均为建库至2021年12月31日,同时查找相关文献的参考文献做补充。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用 RevMan 5.4 软件进行 Meta 分析,估计合并效应量为两组均值差(MD)及其95%可信区间。结果共纳入18篇英文文献,骨折组2 614例患者,对照组4 519人。Meta分析结果显示,骨折组的血清Vit D含量显著低于对照组(MD＝-3.54,95％CI:-5.45~-1.63,P<0.05)。亚组分析结果发现亚洲国家儿童血清Vit D含量骨折组明显低于对照组(MD＝-5.15,95％CI:-9.40~-0.91,P<0.05)。结论儿童骨折患者血清Vit D含量较低与儿童骨折风险增加有关。

Abstract

Objective To systematically evaluate the correlation between serum vitamin D level and the fracture risk in children and adolescents, so as to provide theoretical basis for early prevention of fractures in children. Methods PubMed, Embase, CNKI,VIP and Wangfang Database were searched to retrieve the observational studies on the association between serum vitamin D level and the fracture risk from the establishment of the database to December 31st 2021. Simultaneously, references of related literature were searched. The quality of the literature was evaluated by NOS standard application. Review Manager 5.4 software was used to perform Meta-analysis, the MD value of the combined effect size and its 95% confidence interval(CI) were estimated. Results A total of 18 English articles were included, with 2 614 cases in the fracture group and 4 519 in the control group. Meta-analysis showed that serum Vit D level in the fracture group was significantly lower than that in the control group(MD=-3.54, 95%CI:-5.45 - -1.63, P<0.05). Subgroup analysis showed that the serum Vit D level of Asian children in the fracture group was significantly lower than that in the control group(MD=-5.15, 95%CI:-9.40 - -0.91, P<0.05). Conclusion Lower serum vitamin D level in children with fracture is associated with an increased risk of fracture in children.

导出引用

叶夕霞, 朱之心, 陈明明, 张雅琴, 周静, 曹文婷. 儿童与青少年血清维生素D水平与骨折风险相关性研究的Meta分析[J]. 中国儿童保健杂志. 2023, 31(4): 416-421 https://doi.org/10.11852/zgetbjzz2022-0240

YE Xixia, ZHU Zhixin, CHEN Mingming, ZHANG Yaqin, ZHOU Jing, CAO Wenting. Meta-analysis of the relationship between serum vitamin D level and risk of pediatric fractures[J]. Chinese Journal of Child Health Care. 2023, 31(4): 416-421 https://doi.org/10.11852/zgetbjzz2022-0240

中图分类号： R726.8

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