目的 分析鼻用激素与孟鲁司特钠联合应用对腺样体肥大患儿睡眠质量和临床疗效的影响,为临床诊治提供参考依据。 方法 收集2019年12月—2020年12月间本院收治的400例腺样体肥大患儿,根据随机数字表法分为两组,对照组200例予以鼻用激素治疗,观察组200例予以鼻用激素与孟鲁司特钠联合治疗,8周后观察两组患儿的睡眠质量及临床疗效。 结果 治疗8周后,观察组患儿的总有效率为92.5%,高于对照组(85.0%)(χ2=5.634,P＜0.05);观察组睡眠障碍评分为(5.17±1.05)分 ,A/N值为(0.60±0.05),分别比对照组的(6.60±1.38)及(0.70±0.06)分低(t=11.662,18.107,P＜0.05);观察组的血清白细胞介素-6(IL-6)、白细胞介素-4(IL-4)及白细胞介素-1β(IL-1β)水平均以及嗜酸性粒细胞(EOS)计数、变应原特异性IgE(sIgE)、嗜酸性细胞阳离子蛋白(ECP)表达低于对照组(t=30.936、13.248、19.718、23.190、10.304、39.316,P＜0.05)。结论 鼻用激素与孟鲁司特钠联合应用可以改善腺样体肥大患儿的睡眠质量,有助于提升其临床疗效,值得临床推广使用。
Abstract
Objective To analyze the effects of nasal hormones and montelukast sodium in the treatment of children with adenoid hypertrophy on sleep quality and clinical efficacy, so as to provide reference for clinical diagnosis and treatment. Methods A total of 400 cases of children with adenoid hypertrophy admitted to the Department of Otolaryngology, the Fourth Hospital of Xi'an from December 2019 to December 2020 were selected into this study, and were randomly divided into two groups according to the random number table method, with 200 cases in each group. The control group was treated with nasal hormones, and the observation group received nasal hormones and montelukast sodium treatment. The clinical efficacy, sleep quality of the two groups were observed in 8 weeks. Results After 8 weeks of treatment, the total effective rate of children in the observation group was significantly higher than that in the control group (92.5% vs. 85.00%, χ2=5.634,P<0.05). The score of sleep disorder was 5.17±1.05 and the A/N value was 0.60±0.05, significantly lower than those of the control group (6.60±1.38, 0.70±0.06, t=11.662, 18.107, P<0.05). Moreover, serum levels of IL-6, IL-4 and IL-1β, the EOS count,the expression levels of sIgE andeosinophil cationic protein(ECP) were significantly lower than those of the control group (t=30.936, 13.248, 19.718, 23.190, 10.304, 39.316, P<0.05). Conclusion The combination of nasal hormone and montelukast sodium has a significant effect in children with adenoid hypertrophy, which helps to improve the sleep quality and curative effect of children, and is worth in promoting clinically.
关键词
鼻用激素 /
孟鲁司特钠 /
腺样体肥大 /
睡眠质量 /
血清炎性因子 /
血清变态反应
Key words
nasal hormones /
montelukast sodium /
adenoid hypertrophy /
sleep quality /
serum inflammatory factors /
serum allergy
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