摘要
目的 研究血清趋化素、瘦素、脂联素水平与3~6岁学龄前期儿童单纯性肥胖及代谢的关系,为学龄前单纯性肥胖儿童临床监测及治疗效果提供依据。方法 选取2019年1月—2020年5月于大连市妇幼保健院儿童保健门诊体检的3~6岁儿童为研究对象,获取单纯性肥胖儿童41例作为研究组,另获取同年龄、同时期儿童43例作为对照组。测量其身高和体重,并计算身高别体重;测定血清趋化素、瘦素、脂联素、空腹血糖(FPG)、空腹胰岛素(FINS)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c),同时计算胰岛素抵抗指数。结果 单纯性肥胖组的FINS、胰岛素抵抗指数(HOMA-IR),LDL-c,血清趋化素,瘦素明显高于对照组,差异有统计学意义(t=3.288、2.927、4.939、3.078、5.456,P＜0.05),HDL-c,脂联素明显低于对照组,差异有统计学意义(t=-5.179、-3.145,P＜0.05)。而两组FPG、TG、TC差异无统计学意义(t=0.391、0.768、-0.266,P＞0.05); 趋化素与身高别体重、FINS、HOMA-IR、 LDL-c、瘦素呈正相关(r=0.339、0.416、0.227、0.376、0.266,P＜0.05),与HDL-c、脂联素呈负相关(r=-0.410、-0.309,P＜0.05)。瘦素与身高别体重、FINS、HOMA-IR、 LDL-c、趋化素呈正相关(r=0.492、0.375、0.279、0.269、0.266,P＜0.05),与HDL-c、脂联素呈负相关(r=-0.467、-0.326,P＜0.05)。脂联素与身高别体重、FINS、HOMA-IR,LDL-c、趋化素、瘦素呈负相关(r=-0.296、-0.351、-0.278、-0.229、-0.309、-0.326,P＜0.05),与HDL-c呈正相关(r=0.234,P=0.032)。结论 血清趋化素、瘦素、脂联素水平与学龄前单纯性肥胖儿童糖脂代谢密切相关,这些指标对于识别、监测、干预学龄前单纯性肥胖儿童有着重要意义。
Abstract
Objective To study the correlation of serum chemerin, leptin and adiponectin levels with simple obesity and metabolism in preschool children aged 3 to 6 years, so as to provide basis for clinical monitoring and treatment efficacy evaluation of preschool simple obese children. Methods Children aged 3 to 6 years who underwent physical examination in Child Health Clinic of Dalian Maternal and Child Health Hospital from January 2019 to May 2020 were selected as study subjects. Forty one simple obese children were enrolled in the study group, and meanwhile another 43 children with the same age were selected as the control group. Their height and weight were measured, and calculate the height for weight was calculated. Serum levels of chemerin, leptin, adiponectin, fasting plasma glucose (FPG), fasting insulin (FINS), total triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) were tested, and insulin resistance index was calculated. Results The levels of FINS, HOMA-IR, LDL-c, serum chemerin and leptin in the simple obesity group were significantly higher than those in the control group (t=3.288, 2.927, 4.939, 3.078, 5.456, P＜0.05),while the levels of HDL-c and adiponectin were significantly lower than those in the control group (t=-5.179, -3.145, P＜0.05). But there were no significant differences in the levels of FPG, TG and TC between the two groups (t=0.391, 0.768,-0.266, P＞0.05). Serum chemerin was positively correlated with height for weight and the levels of FINS, HOMA-IR, TG, LDL-c and leptin (r=0.339, 0.416, 0.227, 0.376, 0.266, P＜0.05), and negatively correlated with HDL-c and adiponectin levels (r=-0.410, -0.309, P＜0.05). Leptin level was positively related to height for weight, FINS, HOMA-IR, LDL-C and chemokine levels (r=0.492, 0.375, 0.279, 0.269, 0.266, P＜0.05), and negatively related to HDL-C and adiponectin (r=-0.467,-0.326,P＜0.05). The level of adiponectin was negatively correlated with height for weight, FINS, HOMA-IR, LDL-c, chemerin and leptin (r=-0.296, -0.351, -0.278, -0.229, -0.309, -0.326, P＜0.05), and positively correlated with HDL-c level(r=0.234, P=0.032). Conclusions The levels of serum chemerin, leptin and adiponectin are closely related to glucose and lipid metabolism in preschool simple obese children, which are of great significance for the identification, monitoring and intervention of preschool children with simple obesity.
关键词
学龄前 /
单纯性肥胖 /
趋化素 /
瘦素 /
脂联素
Key words
preschool /
simple obesity /
chemerin /
leptin /
adiponectin
崔一帆, 董明明, 胡丹, 马贤芝, 肖绪武.
血清趋化素、瘦素、脂联素浓度与学龄前单纯性肥胖儿童糖脂代谢的关系[J]. 中国儿童保健杂志. 2022, 30(5): 548-552 https://doi.org/10.11852/zgetbjzz2021-1197
CUI Yi-fan, DONG Ming-ming, HU-Dan, MA Xian-zhi, XIAO Xu-wu.
Correlation of serum chemerin, leptin and adiponectin levels with glucose and lipid metabolism preschool simple obese children[J]. Chinese Journal of Child Health Care. 2022, 30(5): 548-552 https://doi.org/10.11852/zgetbjzz2021-1197
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参考文献
[1] Arroyo-Johnson C,Mincey KD.Obesity epidemiology worldwide[J].Gastroenterol Clin North Am,2016,45(4):571-579.
[2] Poulos SP,Hausman DB,Hausman GJ. The development and endocrine functions of adipose tissue[J].Mol Cell Endocrinol,2010,323(1):20-34.
[3] Collaboration NCDRF. Worldwide trends in body mass index,underweight, overweight, and obesity from 1975 to 2016:A pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults[J]. Lancet,2017,390(10113):2627-2642.
[4] Iacobini C,Pugliese G,Blasetti Fantauzzi C,et al.Metabolically healthy versus metabolically unhealthy obesity[J].Metabolism,2019,92:51-60.
[5] Saukkonen T,Mutt SJ,Jokelainen J,et al.Adipokines and inflammatory markers in elderly subjects with high risk of type 2 diabetes and cardiovascular disease[J].Sci Rep,2018,8(1):12816.
[6] 宋威巍,柏友萍.Chemerin、肥胖与运动研究进展[J].安徽师范大学学报:自然科学版,2018,41(1):98-102.
[7] Niklowitz P, Rothermel J, Lass N, er al. Link between chemerin, central obesity, and parameters of the metabolic syndrome:findings from a longitudinal study in obese children participating in a lifestyle intervention[J]. Int J Obes (Lond),2018, 42(10):1743-1752.
[8] Helfer G, Wu QF. Chemerin:a multifaceted adipokine involved in metabolic disorders[J]. J Endocrinol, 2018,238(2):R79-R94.
[9] Lin X, Yang Y, Qu J, et al. Aerobic exercise decreases chemerin/CMKLR1 in the serum and peripheral metabolic organs of obesity and diabetes rats by increasing PPARγ[J]. Nutr Metab(Lond),2019, 16(1):17.
[10] 林小晶,杨宏芳,王晓慧.有氧运动与饮食控制对2型糖尿病大鼠肝chemerin及其受体CMKLR1的影响[J].中国应用生理学杂志,2017,33(5):426-430,435.
[11] 马敬弟,卢姗,马向华.脂肪细胞因子与肥胖的关系[J].南京医科大学学报:自然科学版,2012,32(12):1743-1745.
[12] 林小晶,王晓慧.炎症因子chemerin在肥胖及其相关疾病中的作用及运动对chemerin 调控的研究进展[J].生理科学进展,2017,48(5):383-387.
[13] Iwase M,Kimura K,Komagome R,et al.Sandwich enzyme-linked immunosorbent assay of canine leptin.[J]. J Vet Med Sci,2000,62(2):207.
[14] 徐晓丽,丁攀,李晓霞,等.瘦素、脂联素与代谢综合征相关指标的关系[J].宁夏医科大学学报,2016,38(2):169-171.
[15] 王春花,王敏,刘鸿丽,等.瘦素与代谢综合征相关性的研究进展[J].当代医药论丛,2019,17(13):35-37.
[16] Li TD,Zeng ZH.Adiponectin as a potential therapeutic target for the treatment of restenosis[J].Bidmed Pharmacother,2018,101:798-804.
[17] 杜苏苏,彭璐婷,武苏,等.肥胖儿童青少年血清脂肪因子与其代谢特征的相关性研究[J].中国循证儿科杂志,2019,14(5):374-379.
[18] Cai X,Li X,Li L,et al. Adiponectin reduces carotid atherosclerotic plaque formation in ApoE-/-mice:roles of oxidative and nitrosative stress and inducible nitric oxide synthase [J].Mol Med Rep,2015,11(3):1715-1721.
[19] Hou N,Du G,Han F,et al.Irisin regulates heme oxygenase-1/adiponectin axis in perivascular adipose tissue and improves endothelial dysfunction in diet-induced obese mice[J].Cell Physiol Biochem,2017,42(2):603-614.
[20] 郭莹莹,边云飞,肖传实.脂联素在代谢综合征及心血管疾病中的研究进展[J].中国动脉硬化杂志,2015,23(5):527-531.
基金
辽宁省自然基金指导计划项目(2019-ZD-1017);大连市科技创新基金计划项目(2019J13SN81)
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