蛋白质糖基化修饰在儿童中枢神经系统疾病中的作用

任玉倩; 陈津津

doi:10.11852/zgetbjzz2021-0768

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中国儿童保健杂志 ›› 2022, Vol. 30 ›› Issue (7) : 755-758. DOI: 10.11852/zgetbjzz2021-0768

综述

蛋白质糖基化修饰在儿童中枢神经系统疾病中的作用

任玉倩¹, 陈津津²

作者信息 +

Role of protein glycosylation in pediatric central nervous system disorders

REN Yu-qian^*, CHEN Jin-jin

Author information +

文章历史 +

摘要

蛋白质糖基化修饰是一种重要的翻译后修饰,对蛋白质的功能和结构形成具有重要作用,参与调控生物体的多项生命活动,如细胞粘附、转移、细胞间通讯、受体激活、信号转导等。近年来发现多种糖基化途径参与大脑发育的过程,异常的糖基化蛋白表达对大脑发育产生负面影响,并参与神经系统疾病的发生、发展。本文就蛋白质的糖基化修饰对神经功能的影响及糖基化异常导致的儿童中枢神经系统疾病进行论述,为儿童中枢神经系统疾病寻找新的糖基化蛋白诊断标志物和治疗靶点提供视角。

Abstract

Protein glycosylation is an important post-translational modification, which plays an important role in the formation of protein function and structure.It is involved in many biological activities, such as cell adhesion, migration, intercellular communication, receptor activation, signal transduction and so on.In recent years, it has been found that a variety of glycosylation pathways are involved in the process of brain development.Abnormal glycosylation protein expression has a negative impact on brain development and participates in the occurrence and development of nervous system diseases.In this review, the effects of glycosylation modification of proteins on neural function and the central nervous system diseases in children caused by abnormal glycosylation are discussed, which provides a new perspective for finding new diagnostic biomarkers and therapeutic targets in pediatric central nervous system disorders.

导出引用

任玉倩, 陈津津. 蛋白质糖基化修饰在儿童中枢神经系统疾病中的作用[J]. 中国儿童保健杂志. 2022, 30(7): 755-758 https://doi.org/10.11852/zgetbjzz2021-0768

REN Yu-qian, CHEN Jin-jin. Role of protein glycosylation in pediatric central nervous system disorders[J]. Chinese Journal of Child Health Care. 2022, 30(7): 755-758 https://doi.org/10.11852/zgetbjzz2021-0768

中图分类号： R748

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基金

国家自然科学基金(81670810);上海市科委政府间国际合作项目(20410712700);上海市科委医学引导类科技支撑项目(18411967700);上海市卫健委老龄化和妇幼健康专项(2020YJZX0207);上海交通大学“交大之星”计划医工交叉研究基金(YG2019ZDB01);上海市儿童健康服务能力建设专项规划高端儿科海外研修团队培养计划(GDEK201710);上海市临床重点专科项(shslczdzk05705);早产儿神经发育迟缓精准评价与预测的多中心研究(SHDC2020CR1047B)。