孤独症谱系障碍重复刻板行为与感觉门控相关性研究

郝汇睿; 董献文; 李恩耀; 樊亚蕾; 成慧; 江淼淼; 赵鹏举

doi:10.11852/zgetbjzz2021-0669

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中国儿童保健杂志 ›› 2022, Vol. 30 ›› Issue (4) : 366-370. DOI: 10.11852/zgetbjzz2021-0669

科研论著

孤独症谱系障碍重复刻板行为与感觉门控相关性研究

郝汇睿, 董献文, 李恩耀, 樊亚蕾, 成慧, 江淼淼, 赵鹏举

作者信息 +

Correlation between repetitive and stereotyped behaviors and sensory gating in autism spectrum disorder

HAO Hui-rui, DONG Xian-wen, LI En-yao, FAN Ya-lei, CHENG hui, JIANG Miao-miao, ZHAO Peng-ju

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摘要

目的探究孤独症谱系障碍(ASD)儿童重复刻板行为的发育轨迹,明确其与大脑感觉门控之间的相关性,以期进一步为临床诊疗提供参考。方法选取2018年8月—2021年5月就诊于郑州大学第五附属医院儿童康复科门诊符合ASD诊断儿童89例,符合全面性发育迟缓(GDD)诊断儿童76例,采用重复行为量表-修订版(RBS-R)评价患儿重复刻板行为,采用感觉门控P50比值评价患儿大脑感觉门控,并分析二者的相关性。结果 ASD及GDD儿童的重复刻板行为总分、低阶及高阶与感觉门控均无相关性(P＞0.05)。ASD儿童重复刻板行为总分、低阶及高阶得分随年龄增长未见明显下降趋势(P＞0.05),GDD儿童重复刻板行为与年龄呈明显负相关(r=-0.43~-0.23,P＜0.05)。结论 ASD儿童重复刻板行为发育轨迹并非简单的负性线性关系,其重复刻板行为与大脑感觉门控无明显相关性,P50可能不是一个有效预测重复刻板行为的指标。

Abstract

Objective To explore the developmental trajectory of restricted and repetitive behavior (RRB) in children with autism spectrum disorder (ASD), and to determine whether there is a correlation between RRB and sensory gating, so as to provide reference for clinical diagnosis and treatment. Methods From August 2018 to May 2021, 89 children with ASD and 76 children with global developmental delay (GDD) in Children's Rehabilitation Department of the Fifth Affiliated Hospital of Zhengzhou University were selected into this study. RRB was assessment by the Repetitive Behavior Scale-Revised (RBS-R), and cerebral sensory gating was evaluated by the sensory gating P50 ratio, and the correlation was analyzed. Results There was no significant correlation of the total scores, low-level and high-level of RRB with sensory gating in ASD children and GDD children (P>0.05). There was no significant decrease with age in the total scores, low-level and high-level of RRB in ASD children (P>0.05). However, RRB score was negatively related to the age of children with GDD (r=-0.43 to -0.23, P<0.01). Conclusions The developmental trajectory of RRB in ASD children is not a simple negative linear curve with age. There is no significant correlation between RRB and sensory gating. P50 may not be an effective index to predict repetitive and stereotyped behaviors.

导出引用

郝汇睿, 董献文, 李恩耀, 樊亚蕾, 成慧, 江淼淼, 赵鹏举. 孤独症谱系障碍重复刻板行为与感觉门控相关性研究[J]. 中国儿童保健杂志. 2022, 30(4): 366-370 https://doi.org/10.11852/zgetbjzz2021-0669

HAO Hui-rui, DONG Xian-wen, LI En-yao, FAN Ya-lei, CHENG hui, JIANG Miao-miao, ZHAO Peng-ju. Correlation between repetitive and stereotyped behaviors and sensory gating in autism spectrum disorder[J]. Chinese Journal of Child Health Care. 2022, 30(4): 366-370 https://doi.org/10.11852/zgetbjzz2021-0669

中图分类号： R749.94

参考文献

[1] Maenner MJ,Shaw KA,Bakian AV, et al. Prevalence and characteristics of autism spectrum disorder among children aged 8 years--autism and developmental disabilities monitoring network, 11 sites, United States, 2018[J]. MMWR Surveill Summ, 2021,70(11):1-16.
[2] Lewis MH, Bodfish JW. Repetitive behavior disorders in autism[J]. Mental Retardation and Developmental Disabilities,1998,4(2):80-89.
[3] 李静亚, 姜志梅, 崔贵霞, 等. 中文版重复刻板行为检查表(修订版)在儿童孤独症群体中的信度和效度分析[J]. 中国中西医结合儿科学, 2013,5(3):208-211.
[4] Baum SH, Stevenson RA, Wallace MT. Behavioral, perceptual, and neural alterations in sensory and multisensory function in autism spectrum disorder[J]. Prog Neurobiol, 2015,134:140-160.
[5] Lane AE, Young RL, Baker AE, et al. Sensory processing subtypes in autism: association with adaptive behavior[J]. J Autism Dev Disord, 2010,40(1):112-122.
[6] Schulz SE, Stevenson RA. Sensory hypersensitivity predicts repetitive behaviours in autistic and typically-developing children[J]. Autism, 2019,23(4):1028-1041.
[7] Bodfish JW, Symons FJ, Parker DE, et al. Varieties of repetitive behavior in autism: comparisons to mental retardation[J]. J Autism Dev Disord, 2000,30(3):237-243.
[8] Boyd BA, Baranek GT, Sideris J, et al. Sensory features and repetitive behaviors in children with autism and developmental delays[J]. Autism Res, 2010,3(2):78-87.
[9] 李晓捷.儿童康复学[M].北京:人民卫生出版社.2018:155.
[10] Bishop SL, Hus V, Duncan A, et al. Subcategories of restricted and repetitive behaviors in children with autism spectrum disorders[J]. J Autism Dev Disord, 2013,43(6):1287-1297.
[11] Richler J, Huerta M, Bishop SL, et al. Developmental trajectories of restricted and repetitive behaviors and interests in children with autism spectrum disorders[J]. Dev Psychopathol, 2010,22(1):55-69.
[12] 莫秀锋. 儿童的重复行为:正常与异常的辨析[J]. 中国特殊教育, 2014,(4):77-82,96.
[13] Lam KSL, Aman MG. The repetitive behavior scale-revised: independent validation in individuals with autism spectrum disorders[J].J Autism Dev Disord, 2007,37(5):855-866.
[14] MacDonald R, Green G, Mansfield R, et al. Stereotypy in young children with autism and typically developing children[J]. Res Dev Disabil, 2007,28(3):266-277.
[15] 李艳, 徐胜, 唐玉苇. 自闭症谱系障碍者局限重复行为研究新进展[J]. 现代特殊教育, 2019,(4):26-34.
[16] Langen M, Durston S, Kas MJ, et al. The neurobiology of repetitive behavior: …and men[J]. Neurosci Biobehav Rev, 2011,35(3):356-365.
[17] Schuetze M, Park MT, Cho IY, et al. Morphological alterations in the thalamus, striatum, and pallidum in autism spectrum disorder[J]. Neuropsychopharmacology, 2016,41(11):2627-2637.
[18] Rojas DC, Peterson E, Winterrowd E, et al. Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms[J]. BMC Psychiatry, 2006,6:56.
[19] Kelly E, Meng F, Fujita H, et al. Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits[J]. Nat Neurosci, 2020,23(9):1102-1110.
[20] Greenwood TA, Light GA, Swerdlow NR, et al. Gating deficit heritability and correlation with increased clinical severity in schizophrenia patients with positive family history[J]. Am J Psychiatry, 2016,173(4):385-391.
[21] Kisley MA, Polk SD, Ross RG, et al. Early postnatal development of sensory gating[J]. Neuroreport, 2003,14(5):693-697.
[22] Brinkman MJ, Stauder JE. Development and gender in the P50 paradigm[J]. Clin Neurophysiol, 2007,118(7):1517-1524.
[23] Crasta JE, Gavin WJ, Davies PL. Expanding our understanding of sensory gating in children with autism spectrum disorders[J]. Clin Neurophysiol, 2021,132(1):180-190.
[24] Orekhova EV, Stroganova TA, Prokofyev AO, et al. Sensory gating in young children with autism: relation to age, IQ, and EEG gamma oscillations[J]. Neurosci Lett, 2008,434(2):218-223.
[25] Li Y, Lopez-Huerta VG, Adiconis X, et al. Distinct subnetworks of the thalamic reticular nucleus[J]. Nature, 2020,583(7818):819-824.
[26] Grunwald T, Boutros NN, Pezer N, et al. Neuronal substrates of sensory gating within the human brain[J]. Biol Psychiatry, 2003,53(6):511-519.
[27] Ross RG, Stevens KE, Proctor WR, et al. Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia[J]. J Child Psychol Psychiatry, 2010,51(5):535-549.
[28] Chen YH, Rodgers J, McConachie H. Restricted and repetitive behaviours, sensory processing and cognitive style in children with autism spectrum disorders[J]. J Autism Dev Disord, 2009,39(4):635-642.
[29] Miller LJ, Anzalone ME, Lane SJ, et al. Concept evolution in sensory integration: a proposed nosology for diagnosis[J]. Am J Occup Ther, 2007,61(2):135-140.
[30] Baranek GT, Foster LG, Berkson G. Tactile defensiveness and stereotyped behaviors[J]. Am J Occup Ther, 1997,51(2):91-95.
[31] Liss M, Saulnier C, Fein D, et al. Sensory and attention abnormalities in autistic spectrum disorders[J]. Autism, 2006,10(2):155-172.
[32] di Renzo M, di Castelbianco FB, Vanadia E,et al. Sensory processing and repetitive behaviors in clinical assessment of preschool children with autism spectrum disorder[J]. J Child Adolesc Behav, 2017, 5:2.