青少年抑郁障碍冷执行功能研究进展

陈海思; 高静芳; 王晓乐; 胡希文

doi:10.11852/zgetbjzz2021-0532

PDF(511 KB)

中国儿童保健杂志 ›› 2022, Vol. 30 ›› Issue (1) : 53-56. DOI: 10.11852/zgetbjzz2021-0532

综述

青少年抑郁障碍冷执行功能研究进展

陈海思¹, 高静芳², 王晓乐², 胡希文²

作者信息 +

Research progress in cold executive dysfunction in adolescents with depression

CHEN Hai-si^*, GAO Jing-fang, WANG Xiao-le, HU Xi-wen

Author information +

文章历史 +

摘要

抑郁障碍患者常起病于青少年期,早期识别是早期干预的基础。研究发现抑郁障碍患者在许多不同的认知领域如注意偏差及在工作记忆、抑制控制等执行功能等方面均持续性存在认知损害。本文主要介绍青少年抑郁障碍冷执行功能的抑制控制、工作记忆及认知灵活性的神经心理学及其脑影像学研究进展,探索青少年抑郁障碍患者的冷执行功能特征。

Abstract

Depression always onsets in adolescence and early recognition is the basis of early intervention.Studies have found persistent cognitive impairment in many different cognitive domains such as attention and executive functions, including working memory and inhibition.This review mainly focuses on the neuropsychological and neuroimaging advances in inhibition and working memory as well as the cognitive flexibility in adolescent depression, in order to explore the characteristics of cold executive functions in adolescent depression.

导出引用

陈海思, 高静芳, 王晓乐, 胡希文. 青少年抑郁障碍冷执行功能研究进展[J]. 中国儿童保健杂志. 2022, 30(1): 53-56 https://doi.org/10.11852/zgetbjzz2021-0532

CHEN Hai-si, GAO Jing-fang, WANG Xiao-le, HU Xi-wen. Research progress in cold executive dysfunction in adolescents with depression[J]. Chinese Journal of Child Health Care. 2022, 30(1): 53-56 https://doi.org/10.11852/zgetbjzz2021-0532

中图分类号： R749.94

参考文献

[1] Darcet F, Gardier AM, Gaillard R, et al.Cognitive dysfunction in major depressive disorder.A translational review in animal models of the disease [J].Pharmaceuticals (Basel),2016,9(1):9.
[2] Vos T, Flaxman AD, Naghavi M, et al.Years lived with disability (ylds) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the global burden of disease study 2010 [J].Lancet,2012,380(9859):2163-2196.
[3] 赵英欣,郑毅.儿童青少年精神障碍流行病学研究进展 [J].中华精神科杂志,2014,47(3):186-189.
[4] Malhi GS Mann JJ.Depression [J].Lancet,2018,392:2299-2312.
[5] 李玖玲,陈星,赵春华.中国儿童青少年抑郁症状流行率的Meta分析 [J].中国儿童保健杂志,2016,24(3):295-298.
[6] 阎丹峰,李陵江.抑郁症患者的认知功能障碍及其临床启示 [J].中华精神科杂志,2018,51(5):343-346.
[7] Wang G, Si T, Li L, et al.Cognitive symptoms in major depressive disorder: Associations with clinical and functional outcomes in a 6-month, non-interventional, prospective study in china [J].Neuropsych Dis Treat,2019,15:1723-1736.
[8] Geraldo A, Azeredo A, Pasion R, et al.Fostering advances to neuropsychological assessment based on the research domain criteria: The bridge between cognitive functioning and physiology [J].Clin Neuropsychol,2019,33(2):327-356.
[9] Zelazo PDM, U.Executive function in typical and atypical development [J].Blackwell, 2010: 574-603.
[10] Chuang J, Hagan C, Murray G, et al.Adolescent major depressive disorder: Neuroimaging evidence of sex difference during an affective go/no-go task [J].Front Psychiatry,2017,8:119.
[11] Liu C, Dai J, Chen Y, et al.Disorder- and emotional context-specific neurofunctional alterations during inhibitory control in generalized anxiety and major depressive disorder [J].Neuroimage-Clin, 2021,30:102661
[12] Lewis G, Button K, Pearson R, et al.Inhibitory control of positive and negative information and adolescent depressive symptoms: A population-based cohort study [J].Psychol Med, 2020:1-11
[13] Jacola L, Willard V, Ashford J, et al.Clinical utility of the n-back task in functional neuroimaging studies of working memory [J].J Clin Exp Neuropsyc,2014,36(8):875-886.
[14] Tamm G, Kreegipuu K, Harro J.Updating facial emotional expressions in working memory: Differentiating trait anxiety and depressiveness [J].Acta psychologica,2020,209:103117.
[15] Nikolin S, Tan Y, Schwaab A, et al.An investigation of working memory deficits in depression using the n-back task: A systematic review and meta-analysis [J].J Affect Disorders, 2021,284:1-8
[16] Goodall J, Fisher C, Hetrick S, et al.Neurocognitive functioning in depressed young people: A systematic review and meta-analysis [J].Neuropsychol Rev, 2018, 28(2):216-231
[17] Ang Y, Frontero N, Belleau E, et al.Disentangling vulnerability, state and trait features of neurocognitive impairments in depression [J].Brain,2020,143(12):3865-3877
[18] 侯庆石.威斯康星分类作业测试(WCST)[J].中华神经外科杂志,2012(12):1283.
[19] Kavanaugh B, Gaudet C, Dupont-Frechette J, et al.Failure to maintain set as a predictor of childhood depression within a children's psychiatric inpatient sample [J].Psychiat Res,2016,246:644-649.
[20] Han G, Helm J, Iucha C, et al.Are executive functioning deficits concurrently and predictively associated with depressive and anxiety symptoms in adolescents? [J].J Clin Child Adolesc,2016,45(1):44-58.
[21] Stange J, Connolly S, Burke T, et al.Inflexible cognition predicts first onset of major depressive episodes in adolescence [J].Depress Anxiety,2016,33(11):1005-1012.
[22] Ing A, Sämann P, Chu C, et al.Identification of neurobehavioural symptom groups based on shared brainmechanisms [J].Nat Hum Behav,2019,3(12):1306-1318.
[23] Barch D, Harms M, Tillman R, et al.Early childhood depression, emotion regulation, episodic memory, and hippocampal development [J].J Abnorm Psychol,2019,128(1):81-95.
[24] 杨春林,潘伟刚.青少年首发抑郁障碍患者头部结构磁共振成像异常分析 [J].临床和实验医学杂志,2019,18(24):2684-2687.
[25] Schmaal L, Hibar D, Sämann P, et al.Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the enigma major depressive disorder working group [J].Mol Psychiatr,2017,22(6):900-909.
[26] Whitfield-Gabrieli S, Wendelken C, Nieto-Castañón A, et al.Association of intrinsic brain architecture with changes in attentional and mood symptoms during development [J].JAMA Psychiat, 2020, 77(4):378-386.
[27] 朱妍,李淑英,吕培培.青少年首发抑郁症患者前扣带回和杏仁核功能连接异常改变研究 [J].中华行为医学与脑科学杂志,2018,27(6):505-510.
[28] Connolly CG, Ho TC, Blom EH, et al. Resting-state functional connectivity of the amygdala and longitudinal changes in depression severity in adolescent depression [J].J Affect Disord,2017,207:86-94.
[29] 刘代焱,王尧.青年中期人群首发重度抑郁障碍弥散张量成像研究 [J].第三军医大学学报,2019,41(18):1807-1814.
[30] Jiang J, Zhao Y, Hu X, et al.Microstructural brain abnormalities in medication-free patients with major depressive disorder: A systematic review and meta-analysis of diffusion tensor imaging [J].J Psychiatr Neurosci,2017,42(3):150-163.
[31] Rizk M, Rubin-Falcone H, Keilp J, et al.White matter correlates of impaired attention control in major depressive disorder and healthy volunteers [J].J Affect Disord,2017,222:103-111.
[32] Riley C, Renshaw P.Brain choline in major depression: A review of the literature [J].Psychiat Re-Neuroim,2018,271:142-153.
[33] Yang X, Langevin L, Jaworska N, et al.Proton spectroscopy study of the dorsolateral prefrontal cortex in youth with familial depression [J].Psychiat Clin Neuro, 2016, 70(7):269-277.
[34] Zetterberg H, Schott J.Biomarkers for alzheimer's disease beyond amyloid and tau [J].Nat Med, 2019, 25(2):201-203.
[35] Mao N, Fang J, Xie H, et al.Correlation between neurochemical metabolism and memory function in adolescent patients with depression: A multi-voxel 1h magnetic resonance spectroscopy study [J].Psychiat Clinl Neuros, 2016, 70(4):167-174.
[36] Feldmann L, Piechaczek C, Pehl V, et al.State or trait? Auditory event-related potentials in adolescents with current and remitted major depression [J].Neuropsychologia, 2018, 113:95-103.
[37] Santopetro N, Kallen A, Threadgill A, et al.Reduced flanker p300 prospectively predicts increases in depression in female adolescents [J].Biol Psychol, 2020, 156:107967.