目的 探讨孕中期解脲支原体(UU)、沙眼衣原体(CT)感染与小于胎龄儿(SGA)的相关性,以期为早期预防不良妊娠结局提供参考依据。方法 选取2018年5月-2020年5月北京市怀柔区妇幼保健院收治的112例分娩SGA的产妇作为观察组,选取同期分娩正常新生儿产妇112例作为对照组。实时荧光定量PCR(qPCR)法进行CT、UU检测;采用Logistic回归分析影响SGA发生的因素。结果 观察组产妇UU感染率、CT感染率及UU+CT感染率(40.18%、24.11%、15.18%)均高于对照组(7.14%、4.46%、2.68%),差异有统计学意义(χ2=33.836、17.646、9.278,P＜0.05)。观察组产妇胎儿宫内窘迫、新生儿窒息、入住新生儿病房、早产、胎膜早破及早发型败血症比例均高于对照组,差异有统计学意义(χ2=4.074、4.573、8.518、9.475、7.146、4.167,P＜0.05)。多因素Logistic回归分析结果显示,UU感染、CT感染均是影响SGA发生的独立危险因素(OR=2.674、2.762,95%CI:1.149~6.223、1.139~6.698,P＜0.05)。结论 孕中期UU、CT感染与SGA有一定联系,对育龄及孕期妇女进行早期UU、CT筛查,具有重要的临床意义。
Abstract
Objective To investigate the correlation of ureaplasma urealyticum(UU) and chlamydia trachomatis(CT) infections in the second trimester of pregnancy with small for gestational age (SGA)infants, in order to provide reference for early prevention of adverse pregnancy outcomes. Methods From May 2018 to May 2020, 112 parturients with SGA infants born in the Beijing Huairou Maternal and Child Health Care Hospital were selected as the observation group, and 112 parturients with normal newborns born at the same period were selected into the control group. Real-time fluorescent quantitative PCR (qPCR) method was used for CT and UU detection. Logistic regression was used to analyze the factors affecting the occurrence of SGA. Results The maternal UU infection rate(40.18%), CT infection rate(24.11%) and UU+CT infection rate(15.18%) of the observation group were higher than those of the control group (7.14%, 4.46%, 2.68%) with significant differences (χ2= 33.836, 17.646, 9.278, P<0.05). The proportions of fetal distress, neonatal asphyxia, admission to neonatal ward, premature delivery, premature rupture of membranes and early-onset sepsis in the observation group were significantly higher than those in the control group (χ2= 4.074, 4.573, 8.518, 9.475, 7.146, 4.167, P<0.05). Multivariate Logistic regression analysis showed that UU infection and CT infection were independent risk factors affecting the occurrence of SGA (OR=2.674, 95%CI:1.149 - 6.223; OR=2.762, 1.139 - 6.698, P<0.05). Conclusions UU and CT infections in the second trimester are related to SGA. Early screening of UU and CT for women of childbearing age and pregnant women has important clinical significance.
关键词
解脲支原体 /
沙眼衣原体 /
感染 /
小于胎龄儿
Key words
ureaplasma urealyticum /
chlamydia trachomatis /
infection /
small for gestational age infants
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参考文献
[1] 陈维,白宇翔,漆洪波,等.前置胎盘与小于胎龄儿关系的临床研究[J].重庆医学,2017,46(25):3486-3488.
[2] 李敏遐.近足月小于胎龄儿围生期并发症发生情况和危险因素分析[J].蚌埠医学院学报,2017,42(2):207-209.
[3] Griffi M,Seed PD,Duckworth S,et al.Predicting delivery of a small-for-gestational-age infant and adverse perinatal outcome in women with suspected pre-eclampsia[J].Ultrasound Obst Gyn,2018,51(3):304-305.
[4] 毛宝宏,王燕侠,周丽,等.孕期HBV感染及肝内胆汁淤积症对小于胎龄儿与低出生体重的交互影响[J].中华疾病控制杂志,2019,23(1):29-33,55.
[5] 刘慧,谢集健,张玮.产前肌注糖皮质激素对早产小于胎龄儿病死率和主要并发症的影响[J].临床和实验医学杂志,2018,17(15):1676-1679.
[6] 刘水音.女性生殖道感染沙眼衣原体和解脲支原体检测结果研究[J].实用妇科内分泌电子杂志,2019,6(27):19,41.
[7] 武士敏,张洁,万晓琴.胎膜早破与孕妇沙眼衣原体、解脲支原体感染的关系及其对母婴结局的影响[J].陕西医学杂志,2017,46(10):1396-1398.
[8] 朱丽,张蓉,张淑莲,等.中国不同胎龄新生儿出生体重曲线研制[J].中华儿科杂志,2015,53(2):97-103.
[9] 王丽珍,李飞平,范海玲,等.足月小于胎龄儿医院感染的危险因素分析[J]. 中华医院感染学杂志,2016,25(3):676-678.
[10] 刘婷,陈先春,肖九长.赣南地区女性生殖道解脲脲原体及沙眼衣原体感染状况分析[J].实验与检验医学,2018,36(3):374-375,400.
[11] 陈佳婕,张欢欢,贾亦斐,等.10676例泌尿生殖道感染门诊患者淋球菌、沙眼衣原体和解脲支原体感染分析[J].传染病信息,2020,33(3):236-238.
[12] 李再仪,马琳,黎伟豪,等.解脲支原体、沙眼衣原体感染与输卵管性不孕相关性研究[J].中国实用妇科与产科杂志,2019,35(11):1265-1268.
[14] 孙莉莉.未足月胎膜早破与B族链球菌、解脲支原体及沙眼衣原体感染关系的相关性研究[J].中国妇幼保健,2019,34(20):4622-4625.
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