目的 调查注意缺陷多动障碍(ADHD)儿童过敏性疾病的发生情况,为ADHD的治疗和预防提供理论依据。方法 采用病例对照研究,选择2019年10月-2020年4月上海市儿童医院儿童保健科就诊的800例ADHD儿童为ADHD组,同时选取800例健康体检儿童设为对照组,通过调查问卷的形式,收集两组儿童的人口学资料及临床病史资料,采用单因素χ2检验比较ADHD组和对照组儿童过敏性疾病的患病率,采用Logistic回归模型分析不同过敏性疾病共患时儿童ADHD患病风险及抗过敏治疗对ADHD症状的影响。结果 ADHD组儿童过敏性疾病患病率与对照组差异有统计学意义(χ2=23.220,P<0.001);单一过敏性疾病组儿童ADHD患病风险OR值为1.681(95%CI:1.163~2.375),混合过敏性疾病组儿童ADHD患病风险OR值为2.494(95%CI:1.912~3.254);当ADHD患儿出现过敏症状时,58.2%的患儿ADHD症状较前加重,其中混合过敏性疾病组ADHD症状较前加重的患儿比例高于单一过敏性疾病组(60.6% vs.53.7%,χ2＝434.161,P<0.001)。结论 ADHD儿童过敏性疾病患病率高于对照组;过敏性疾病增加儿童 ADHD的患病风险,过敏性疾病共患种类越多,ADHD患病风险越高。
Abstract
Objective To investigate the prevalence of allergic diseases in children with attention deficit hyperactivity disorder(ADHD) aged 4 to 12 years,in order to provide theoretical basis for the prevention and treatment of ADHD. Methods A case-control study was adopted. From October 2019 to April 2020,800 children with ADHD in the Department of Child Healthcare of Shanghai Children's Hospital were enrolled in the ADHD group,meanwhile 800 healthy children were selected as the control group. Demographic data and clinical disease data of the two groups were collected by questionnaire. Univariate analysis was used to compare the prevalence of allergic diseases between ADHD group and control group. Logistic regression analysis was used to analyze the risk of ADHD in children with co-morbidities of allergic diseases and the effect of anti-allergic treatment on the symptoms of ADHD. Results There was significant difference in the prevalence of allergic diseases between ADHD group and control group(χ2=23.220,P<0.001). The risk of ADHD in single allergic disease group was 1.681(95%CI: 1.163 - 2.375),which was 2.494(95% CI:1.912 - 3.254) in the mixed allergic disease group. When children with ADHD developed allergic symptoms,58.2% of them had worse ADHD symptoms than before. The proportion of ADHD in children with mixed allergic diseases was higher than that in children with single allergic diseases(60.6% vs. 53.7%,χ2=434.161,P<0.001). Conclusion Allergic diseases may increase the risk of ADHD in children,and the more co-morbidities of allergic diseases,the higher the risk of ADHD.
关键词
注意缺陷多动障碍 /
过敏性疾病 /
脑-肠轴 /
儿童
Key words
attention deficit hyperactivity disorder /
allergic diseases /
brain-gut axis /
children
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基金
上海市卫健委项目(2020YGZX203);上海市公共卫生体系建设三年行动计划项目(QWV-10.1-XK19)
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