目的 分析孤独症谱系障碍(ASD)合并癫痫患儿临床和脑电图(EEG)特征,为临床完善ASD共患癫痫的诊疗提供线索。方法 选取2017年1月-2019年12月就诊于河北省儿童医院的120例ASD合并癫痫的患儿为研究对象,对其临床特点和EEG特征进行回顾性分析。结果 ASD合并癫痫患儿癫痫发作以局灶性发作(83.3%)为主,5～7岁时达到高峰,智力水平低的患儿所占比例高。EEG放电最常出现在部位是额区(40%)和颞区(30%),患儿的智力水平与发作间期癫痫样放电指数(IEA)呈负相关(r=-0.736,P<0.001)。结论 ASD合并癫痫有其自身的临床特点,EEG作为评估脑功能的方法,在疾病的诊疗中有着很高的应用价值。
Abstract
Objective To analyze the clinical and electroencephalogram(EEG)features in children with autism spectrum disorder(ASD)combined with epilepsy,in order to provide clues for optimizing the clinical treatment of these children. Methods A total of 120 children with ASD combined with seizures in Children's Hospital of Hebei Province from January 2017 to December 2019 were enrolled in this study. Their clinical features and EEG features were retrospectively analyzed. Results The features of seizures in ASD children combined with epilepsy were mainly focal seizures(83.3%),which peaked at 5 to 7 years old,and the proportion of children with low intelligence level was high.EEG discharges were most common in the frontal region(40%) and temporal area(30%).The intelligence level of the patients was negatively correlated with the interictal epileptiform activity(IEA)(r=-0.736,P<0.001). Conclusions ASD combined with epilepsy has its own clinical features.As a method to evaluate brain function,EEG has a high application value in the diagnosis and treatment of diseases.
关键词
孤独症谱系障碍 /
癫痫 /
脑电图 /
智力水平 /
儿童
Key words
autism spectrum disorder /
epilepsy /
electroencephalogram /
intelligence level /
children
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基金
河北省卫计委2017年医学课题研究重点课题计划(20170397)
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