微小RNA与儿童神经精神障碍之间关系的研究进展

张红梅; 贾美香; 李素水; 薛曼; 孙志刚

doi:10.11852/zgetbjzz2021-0078

PDF(567 KB)

中国儿童保健杂志 ›› 2022, Vol. 30 ›› Issue (3) : 276-280. DOI: 10.11852/zgetbjzz2021-0078

综述

微小RNA与儿童神经精神障碍之间关系的研究进展

张红梅¹, 贾美香², 李素水³, 薛曼³, 孙志刚³

作者信息 +

Research progress on the relationship between microRNA and neuropsychiatric disorders in children

ZHANG Hong-mei^*, JIA Mei-xiang, LI Su-shui, XUE Man, SUN Zhi-gang

Author information +

文章历史 +

摘要

微小RNA是一组短的内源性非编码RNA分子,具有调控基因表达作用,对中枢神经系统神经元增殖、分化、突触形成、突触可塑性和细胞凋亡有重要作用。大量研究证实不同脑区的微小RNA表达模式改变可能参与了孤独症谱系障碍等儿童神经精神障碍的发生和发展,微小RNA有望成为早期诊断的生物学标记物和研制新药的靶目标。

Abstract

MicroRNA is a group of short endogenous non-coding RNA molecules that regulate gene expression and play an important role in the proliferation, differentiation, synaptic formation, synaptic plasticity and apoptosis of neurons in the central nervous system.A large number of studies have confirmed that changes in the expression pattern of microRNA in different brain regions may be involved in the occurrence and development of children's neuropsychiatric disorders such as autism spectrum disorders.MicroRNA is expected to become a biomarker for early diagnosis and a target for the development of new drugs.

导出引用

张红梅, 贾美香, 李素水, 薛曼, 孙志刚. 微小RNA与儿童神经精神障碍之间关系的研究进展[J]. 中国儿童保健杂志. 2022, 30(3): 276-280 https://doi.org/10.11852/zgetbjzz2021-0078

ZHANG Hong-mei, JIA Mei-xiang, LI Su-shui, XUE Man, SUN Zhi-gang. Research progress on the relationship between microRNA and neuropsychiatric disorders in children[J]. Chinese Journal of Child Health Care. 2022, 30(3): 276-280 https://doi.org/10.11852/zgetbjzz2021-0078

中图分类号： R749.94

参考文献

[1] Paul S, Reyes PR, Garza BS, Sharma A.MicroRNAs andchild neuropsychiatric disorders:a brief review[J].Neurochem Res, 2020,45(2):232-240.
[2] Lassandro G, Ciaccia L, Amoruso A, et al.Focus on microRNAs as biomarker in pediatric diseases[J].Curr Pharm Des 2021;27(6):826-832.
[3] Wu XK, Li WR, Zheng Y.Recent progress on relevant microRNAs in autism spectrum disorders[J].Int J Mol Sci,2020,21(16):5904.
[4] Vasu MM, Sumitha PS, Rahna P, et al.microRNAs in autism spectrum disorders[J].Curr Pharm Des,2019,25(41):4368-4378.
[5] Yu D, Jiao X, Cao T, et al.Serum miRNA expression profiling reveals miR-486-3p may play a significant role in the development of autism by targeting ARID1B[J].Neuroreport, 2018,29(17):1431-1436.
[6] Shen L, Lin Y, Sun Z, et al.Knowledge-guided bioinformatics model for identifying autism spectrum disorder diagnostic microRNA biomarkers[J].Sci Rep,2016,6:39663.
[7] Huang F, Long Z, Chen Z, et al.Investigation of gene regulatory networks associated with autism spectrum disorder based on miRNA expression in China[J].PLoS ONE,2015,10(6):e0129052.
[8] Kichukova TM, Popov NT, Ivanov IS, et al.Profiling of circulating serum microRNAs in children with autism spectrum disorder using stem-loop qRT-PCR assay[J].Folia Med, 2017,59(1):43-52.
[9] Nguyen LS, Lepleux M, Makhlouf M, et al.Profiling olfactory stem cells form living patients identifies miRNAs relevant for autism pathophysiology[J].Mol Autism, 2016,7:1.
[10] Danesi C, Keinénen K, Castrén ML.Dysregulated Ca²⁺-permeable AMPA receptor signaling in neural progenitors modeling fragile X syndrome[J].Front Synaptic Neurosci, 2019,11:2.
[11] Hicks SD, Carpenter RL, Wangner KE, et al.Saliva microRNA differentiates children with autism from peers with typical and atypical development[J].J Am Acad Child Adolesc Psychiatry, 2020,59(2):296-308.
[12] Srivastav S, Walitza S, Grünblatt E.Emerging role of miRNA in attention deficit hyperactivity disorder:a systematic review[J].Atten Deficit Hyperact Disord, 2018,10(1)49-63.
[13] Nuzziello N, Craig F, Simone M, et al.Integrated analysis of microRNA and mRNA expression profiles:an attempt to disentangle the complex interaction network in attention deficit hyperactivity disorder[J].Brain Sci, 2019,9(10):288.
[14] Wu LH, Peng M, Yu M, et al.Circulating microRNA Let-7d in attention-deficit/hyperactivity disorder[J].Neuromol Med, 2015,17(2):137-146.
[15] Sánchez-Mora C, Garcia-MartĀnez I, Pagerols M, et al.Correlation analysis of miRNA and mRNA expression profiles in peripheral blood mononuclear cells from ADHD patients and controls[J].Eur Neuropsychopharmacol, 2019,29:S887.
[16] Zadehbagheri F, Hosseini E, Bagheri-Hosseinabadi Z, et al.Profiling of miRNAs in serum of children with attention-deficit hyperactivity disorder shows significant alterations[J].J Psychiatr Res, 2019,109:185-192.
[17] Garcia-Martínez I, Sánchez-Mora C, Pagerols M, et al.Preliminary evidence for association of genetic variants in pri-miR-34b/c and abnormal miR-34c expression with attention deficit and hyperactivity disorder[J].Transl Psychiatry, 2016,6(8):e879.
[18] Lai CY, Lee SY, Scarr E, et al.Aberrant expression of microRNAs as biomarker for schizophrenia:From acute state to partial remission, and from peripheral blood to cortical tissue[J].Transl Psychiatry, 2016,6(1):e717.
[19] Brum CB, Paixão-Cǒrtes VR, Carvalho AM, et al.Genetic variants in miRNAs differentially expressed during brain development and their relevance to psychiatric disorders susceptibility[J].World J Biol Psychiatry, 2020,10:1-12.
[20] Kimoto S, Glausier JR, Fish KN, et al.Reciprocal alterations in regulator of g protein signaling 4 and micro RNA16 in schizophrenia[J].Schizophr Bull, 2016,42 (2):396-405.
[21] Henshall DC, Hamer HM, Pasterkamp RJ, et al.MicroRNAs in epilepsy:pathophysiology and clinical utility[J].Lancet Neurol, 2016,15(13):1368-1376.
[22] Rudov A, Rocchi MBL, Accorsi A, et al.Putative miRNAs for the diagnosis of dyslexia,dyspraxia, and specific language impairment[J].Epigenetics, 2013,8(10):1023-1029.
[23] Rizzo R, Ragusa M, Barbagallo C, et al.Circulating miRNAs profoles in Tourette syndrome:Molecular data and clinical implications[J].Mol Brain, 2015,8:44.
[24] Pagliaroli L, Vereczkei A, Padmanabhuni SS, et al.Association of genetic variation in the 3'UTR of LHX6, IMMP2L,and AADAC with Tourette syndrome[J].Front Neurol, 2020,11:803.
[25] Reschke CR, Silva LFA, Norwood BA, et al.Potent anti-seizure effects of locked nucleic acid antagomiRes targeting miR-134 in multiple mouse and rat models of epilepsy[J].Mol Ther Nucleic Acids, 2017,6:45-56.
[26] Zhang H, Qu Y, Wang A.Antagonist targeting microRNA-146a protects against lithium-pilocarpine-induced status epilepticus in rats by nuclear factor-κΒ pathway[J].Mol Med Rep, 2018,17:5356-5361.
[27] Bielefeld P, Schouten M, Meijer GM, et al.Co-administration of anti microRNA-124 and-137 oligonucleotides prevents hippocampal neural stem cell loss upon non-convulsive seizures[J].Front Mol Neurosci, 2019,12:31.
[28] Kos A, Olde Loohuis N, Meinhardt J, et al.MicroRNA-181 promotes synaptogenesis and attenuates axonal outgrowth in cortical neurons[J].Cell Mol Life Sci, 2016,73(18):3555-3567..