早产儿内分泌功能与生长发育

杨凡; 谢华

doi:10.11852/zgetbjzz2020-2048

PDF(729 KB)

中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (3) : 233-237. DOI: 10.11852/zgetbjzz2020-2048

专家笔谈

早产儿内分泌功能与生长发育

杨凡, 谢华

作者信息 +

Endocrine function and growth and development of preterm infants

YANG Fan, XIE Hua

Author information +

文章历史 +

摘要

内分泌功能对机体正常生长发育具有重要调节作用,早产儿由于下丘脑-垂体轴发育不成熟及多种内分泌激素水平异常,常导致出现一系列近期及远期并发症,影响生长发育,部分患儿还可出现成年期代谢综合征。

Abstract

Endocrine function plays an important role in regulating normal growth and development of the body.Due to the immaturity of the hypothalamic-pituitary axis and abnormal levels of various endocrine hormones, premature infants often develop a series of recent and long-term complications that affect growth and development, and some of them may also develop metabolic syndrome in adulthood.

导出引用

杨凡, 谢华. 早产儿内分泌功能与生长发育[J]. 中国儿童保健杂志. 2021, 29(3): 233-237 https://doi.org/10.11852/zgetbjzz2020-2048

YANG Fan, XIE Hua. Endocrine function and growth and development of preterm infants[J]. Chinese Journal of Child Health Care. 2021, 29(3): 233-237 https://doi.org/10.11852/zgetbjzz2020-2048

中图分类号： R174

参考文献

[1] Leger J, Olivieri A, Donaldson M, et al.European Society for Paediatric Endocrinology consensus guidelines on screening,diagnosis,and management of congenital hypothyroidism[J].J Clin Endocrinol Metab, 2014,9(2):363-384.
[2] Mughal BB, Fini JB, Demeneix B.Thyroid disrupting chemicals and brain development:An update[J].Endocrine Connections, 2018,7(4):160-186.
[3] Cherella CE, Wassner AJ.Congenital hypothyroidism:insights into.pathogenesis and treatment[J].Int J Pediatr Endocrinol, 2017, 2017:11.
[4] 齐薛浩, 杨琳.早产儿甲状腺功能的研究进展[J].中国妇幼健康研究, 2016, 27(4):530-532.
[5] Clause M.Newborn screening for congenital hypothyroidism[J].Texas Medicine, 2013, 28(6):603-608.
[6] Jones JH, Smith S,Dorrian C, et al.Permanent congenital hypothyroidism with blood spot thyroid stimulating hormone＜10 mU/L[J].Arch Dis Child, 2018, 103(1):65-67.
[7] Kilberg MJ, Rasooly IR, Lafranchi SH, et al.Newborn screening.in the US May Miss mild persistent hypothyroidism[J].J Pediatr, 2018, 192:204-208.
[8] Setian NS.Hypothyroidism in children:diagnosis and treatment[J].J Pediatr (RioJ), 2007, 83(Suppl 5):209-216.
[9] Bijarnia S, Wilcken B, Wiley VC.Newborn screening for congenital hypothyroidism in very-low-birth-weight babies:the need for a second test[J].J Inherit Metab Dis, 2011, 34(3):827-833.
[10] Bongers-Schokking JJ.Pre- and postnatal brain development in neonates with congenital hypothyroidism[J].J Pediatr Endocrinol Metab, 2001, 14 (Suppl 6):1463-1468.
[11] Salerno M, Militerni R, Bravaccio C, et al.Effect of different starting doses of levothyroxine on growth and intellectual outcome at four years of age in congenital hypothyroidism[J].Thyroid, 2002, 12(1):45-52.
[12] Tuhan H, Abaci A, Cicek G, et al.Levothyroxine replacement in primary congenital hypothyroidism:the higher the initial dose the higher the rate of overtreatment[J].J Pediatr Endocrinol Metab, 2016, 29(2):133-138.
[13] Korevaar TIM, Layal C, Jaddoe VWV, et al.Maternal and birth characteristics are determinants of offspring thyroid function[J].J Clin Endocrinol Metab, 2016, 101(1):206-213.
[14] Aktas ON, Gursoy T, Soysal E, et al.Thyroid hormone levels in late preterm, early term and term infants:a study with healthy neonates revealing reference values and factors affecting thyroid hormones[J].J Pediatr Endocrinol Metab, 2017, 30(11):1191-1196.
[15] Ng SM, Watson G, TurnerMA, et al.Do maternal factors influence neonatal thyroid status in the extreme premature infant?[J].J Matern Fetal Neonatal Med, 2015, 28(15):1846-1849.
[16] 钟向明, 李敏洪, 陈汛, 等.四种新生儿常见病因对甲状腺功能的影响[J].中国新生儿科杂志, 2015, 30(3):183-187.
[17] 周进福, 罗金英, 赵红, 等.125例新生儿先天性甲状腺功能减低症围产因素分析[J].中华流行病学杂志, 2015,36(7):747-751.
[18] Brit JM,Wassenaer AGV, Dekker FW, et al.Neonatal thyroxine supplementation in very preterm children:developmental outcome evaluated at early school age[J].Pediatrics, 2001, 107(4):712-718.
[19] Chung HR, Shin CH, Yang SW, et al.High incidence of thyroid dysfunction in preterm infants[J].J Korean Med Sci, 2009, 24(4):627-631.
[20] Cuestas E,Gaido MI, Capra RH.Transient neonatal hyperthyrotropinemia is a risk factor for developing persistent hyperthyrotropinemia in childhood with repercussion on developmental status[J].Eur J Endocrinol, 2015, 172(4):483-490.
[21] Kaplan SL, Grumbach MM, Shepard TH.The ontogenesis of human fetal hormones.I.Growth hormone and insulin[J].J Clin Invest, 1972, 51(12):3080-3093.
[22] Cornblath M, Parker ML, Reisner SH, et al.Secretion and metabolism of growth hormone in premature and full-term infants[J].J Clin Endocrinol Metab, 1965, 25(2):209-218.
[23] 刘伟,李文斌,陈治军,等.胰岛素样生长因子-1对新生大鼠神经细胞氧化损伤保护作用的研究[J].中国当代儿科杂志,2014, 16(2):203-207.
[24] Pérez-Muñuzuri A, Fernández-Lorenzo JR, Couce-Pico ML, et al.Serum levels of IGF1 are a useful predictor of retinopathy of prematurity[J].Acta Paediatr, 2010, 99(4):519-525.
[25] Chemtob S.A convenient alternative approach to screen for retinopathy of prematurity[J].Acta Paediatr, 2010, 99(4):494-496.
[26] Capoluongo E, Ameglio F, Zuppi C.Insulin-like growth factor-I and complications of prematurity:a focus on bronchopulmonary dysplasia[J].Clin Chem Lab Med, 2008, 46(8):1061-1066.
[27] 尹路, 杨琍琦.胰岛素样生长因子1在早产儿相关疾病中作用的研究进展[J].医学综述, 2015,21(10):1765-1768.
[28] Pepe GJ, Albrecht ED.Actions of placental and fetal adrenal steroid hormones in primate pregnancy[J].Endocr Rev, 1995, 16(5):608-648.
[29] Ng PC.Is there a normal range of serum cortisol concentration for preterm infants?[J].Pediatrics, 2008, 122(4):873-875.
[30] Watterberg KL, Gerdes JS, Cole CH, et al.Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia:a multicenter trial[J].Pediatrics, 2007, 114:1649-1657.
[31] Ng PC, Lam CWK, Lee CH, et al.Reference ranges and factors affecting the human corticotropin-releasing hormone test in preterm, very low birth weight infants[J].J Clin Endocrinol Metab,2002,87(10):4621-4628.
[32] Urakami T, Nagano N, Suzukj J, et al.Origin and characteristics of glycogen cells in the developing murine placenta[J].Pediatr Int, 2011, 53(1):46.
[33] Kairamkonda VR, Khashu M.Controversies in the management of hyperglycemia in the ELBW infant[J].Indian Pediatrics, 2008, 45(1):29-38.
[34] van Kempen VAMW.Stimulation of gluconeogenesis by intravenous lipids in preterm infants:response depends on fatty acid profile[J].Am J Physiol Endocrinol Metab, 2006, 290(4):e723-e730.
[35] 宋迎冬, 王利平, 徐丁,等.早产儿代谢性骨病研究进展[J].中国儿童保健杂志, 2018,26(9):981-984.
[36] Greer FR.Calcium and phosphorus and the preterm infant[J].Neo Rev, 2016, 17(4):e195-e202.
[37] Cheema ZF, Santillano DR, Wade SB, et al.The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins[J].BMC Neurosci, 2004, 5:11.
[38] 周建国,张秋丽,王洪波,等.早产儿雌激素水平的检测及临床生理学意义的探讨[J].吉林医学, 2011, 32(8):1527-1528.
[39] 中华预防医学会出生缺陷预防与控制专业委员会新生儿筛查学组, 中国医师协会青春期医学专业委员会临床遗传学组, 中华医学会儿科学分会内分泌遗传代谢学组.先天性肾上腺皮质增生症新生儿筛查共识[J].中华儿科杂志, 2016, 54(6):404-409.