目的 评价脑源性神经营养因子(BDFN)基因Val66Met多态性与注意缺陷多动障碍(ADHD)易感性的关系,以期为ADHD的遗传病因学研究提供线索。方法 计算机检索CNKI、WanFang、PubMed、EMbase、Web of Science数据库,搜集公开发表的有关BDNF基因Val66Met多态性与ADHD易感性相关的病例对照研究,检索时限为建库至2020年4月。由2名研究者独立筛选文献、提取资料并对纳入研究进行质量评价后,采用RevMan 5.3和Stata11.0软件进行 Meta 分析。结果 共纳入9篇文献,8 458例样本(其中病例4 247例,对照4 211例)。分析结果显示,rs6265多态性与注意缺陷多动障碍易感性无关(显性模型:OR=0.96,95%CI:0.87～1.06,P=0.40;隐性模型:OR=1.01,95%CI:0.88～1.15,P=0.92;加性模型:OR=0.95,95%CI:0.85～1.08,P=0.45)。结论 脑源性神经营养因子基因Val66Met多态性与注意缺陷多动障碍易感性无关。
Abstract
Objective To evaluate the association between brain derived neurotrophic factor (BDFN) Val66Met gene polymorphism and attention deficit/hyperactivity disorder (ADHD), in order to provide clues for research on genetic etiology of ADHD. Methods The CNKI, WanFang, PubMed, EMbase and Web of Science databases were conducted to collect published case-control studies on the association between Val66Met and ADHD from establishment to April 2020.Two reviewers independently screened the literature, extracted the data, and assessed the quality of included studies.RevMan 5.3 and Stata 11.0 software then were used to perform meta-analysis. Results Totally 9 articles were included with 8 458 samples (including 4 247 cases and 4 211 controls).Meta-analysis indicated that rs6265 was not associated with the susceptibility to ADHD (dominant gene model: OR=0.96, 95%CI:0.87 - 1.06, P=0.40 ; recessive model: OR=1.01, 95%CI:0.88 - 1.15, P=0.92; additive model: OR=0.95,95%CI:0.85 - 1.08,P=0.45). Conclusion The polymorphism of BDNF Val66Met gene is not associated with susceptibility to ADHD.
关键词
脑源性神经营养因子 /
Val66Met /
注意缺陷多动障碍 /
Meta分析
Key words
brain derived neurotrophic factor(BDNF) /
Val66Met /
attention deficit/hyperactivity disorder /
Meta-analysis
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基金
武汉市卫健委科研计划资助项目(WG17Z02)
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