围生期暴露与儿童支气管哮喘相关性的研究进展

胡隆基; 曲书强

doi:10.11852/zgetbjzz2020-1861

PDF(494 KB)

中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (12) : 1325-1328. DOI: 10.11852/zgetbjzz2020-1861

综述

围生期暴露与儿童支气管哮喘相关性的研究进展

胡隆基, 曲书强

作者信息 +

Research progress of perinatal exposure and bronchial asthma in children

HU Long-ji, QU Shu-qiang

Author information +

文章历史 +

摘要

支气管哮喘是一种以慢性气道炎症和气道高反应性为特征的异质性疾病,我国儿童支气管哮喘的患病率呈逐年上升趋势,总体控制水平仍不理想。越来越多的证据表明,在生命早期发生的负面事件,甚至在围生期,会显著增加生命后期哮喘和肺功能不良的风险。本文就围生期暴露与儿童支气管哮喘相关性的研究现状进行综述。

Abstract

Bronchial asthma is a heterogeneous disease characterized by chronic airway inflammation and airway hyperresponsiveness. The prevalence rate of bronchial asthma in Chinese children is increasing year by year, and the overall level of control is still not ideal in Chinese children. There is growing evidence that negative events occurring early in life, even in the perinatal period, significantly increase the risk of asthma and poor pulmonary function later in life. This article reviews the researches on the relationship between perinatal exposure and bronchial asthma in children.

导出引用

胡隆基, 曲书强. 围生期暴露与儿童支气管哮喘相关性的研究进展[J]. 中国儿童保健杂志. 2021, 29(12): 1325-1328 https://doi.org/10.11852/zgetbjzz2020-1861

HU Long-ji, QU Shu-qiang. Research progress of perinatal exposure and bronchial asthma in children[J]. Chinese Journal of Child Health Care. 2021, 29(12): 1325-1328 https://doi.org/10.11852/zgetbjzz2020-1861

中图分类号： R725.6

参考文献

[1] 鲍一笑,陈爱欢,符州,等.儿童支气管哮喘诊断与防治指南(2016年版)[J].中华儿科杂志,2016,54(3):167-181.
[2] 全国儿科哮喘防治作组.第三次中国城市儿童哮喘流行病学调查[J]. 中华儿科杂志,2013,51(10):729-735.
[3] Bobolea I,Arismendi E, Valero A,et al.Early life origins of asthma: a review of potential effectors[J].J Investig Allergol Clin Immunol,2019,29(3):168-179.
[4] Liu X,Agerbo E,Schlünssen V,et al.Maternal asthma severity and control during pregnancy and risk of offspring asthma[J].J Allergy Clin Immunol,2018,141(3):886-892.
[5] Abdullah K,Zhu J,Gershon A,et al. Effect of asthma exacerbation during pregnancy in women with asthma: a population-based cohort study[J]. Eur Respir J,2020,55(2):1901335.
[6] Stokholm J,Sevelsted A,Anderson UD,et al. Preeclampsia associates with asthma, allergy, and eczema in childhood[J]. Am J Respir Crit Care Med,2017,195(5):614-621.
[7] Mirzakhani H,Carey VJ,McElrath TF,et al.Impact of preeclampsia on the relationship between maternal asthma and offspring asthma. An observation from the VDAART clinical trial[J].Am J Respir Crit Care Med, 2019,199(1):32-42.
[8] Postma DS,Bush A,van den Berge M.Risk factors and early origins of chronic obstructive pulmonary disease[J].Lancet,2015,385(9971):899-909.
[9] Zugna D,Galassi C,Annesi-Maesano I,et al.Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts[J].Int J Epidemiol, 2015,44(1):199-208.
[10] Marin-Juez R,Jong-Raadsen S,Yang S,et al.Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish[J].J Endocrinol,2014,222(2):229-241.
[11] Martinez MP,Lin J,Chow T,et al.Maternal gestational diabetes and type 2 diabetes during pregnancy and risk of childhood asthma in offspring[J].J Pediatr,2020,219:173-179.
[12] Liu X,Andersen SL,Olsen J,et al. Maternal hypothyroidism in the perinatal period and childhood asthma in the offspring[J].Allergy,2018,73(4):932-939.
[13] Liu SF,Zhou B,Wang YF,et al.Pre-pregnancy maternal weight and gestational weight gain increase the risk for childhood asthma and wheeze: An updated Meta-analysis[J].Front Pediatr,2020,8:134.
[14] Rizzo GS,Sen S.Maternal obesity and immune dysregulation in mother and infant: a review of the evidence[J].Paediatr Respir Rev,2015,16(4):251-257.
[15] Bisgaard H,Stokholm J,Chawes BL,et al. Fish oil-derived fatty acids in pregnancy and wheeze and asthma in offspring[J].N Engl J Med,2016,375(26):2530-2539.
[16] Stratakis N,Roumeliotaki T,Oken E,et al. Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: a pooled analysis of 18 European and US birth cohorts[J].Int J Epidemiol, 2017,46(5):1465-1477.
[17] Minihane AM.Impact of genotype on EPA and DHA status and responsiveness to increased intakes[J].Nutrients,2016,8(3):123.
[18] Harvey NC,Holroyd C,Ntani G,et al.Vitamin D supplementation in pregnancy: a systematic review[J].Health Technol Assess, 2014,18(45):1-190.
[19] Litonjua AA,Carey VJ,Laranjo N,et al.Effect of prenatal supplementation with vitamin D on asthma or recurrent wheezing in offspring by age 3 years: the VDAART randomized clinical trial[J].JAMA,2016,315(4):362-370.
[20] Hornsby E,Pfeffer PE,Laranjo N,et al.Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial[J].J Allergy Clin Immunol,2018,141(1):269-278.
[21] Li W,Xu B,Cao Y,et al.Association of maternal folate intake during pregnancy with infant asthma risk[J].Sci Rep,2019,9(1):8347.
[22] Parr CL,Magnus MC,Karlstad,et al.Vitamin A and D intake in pregnancy, infant supplementation, and asthma development: the Norwegian mother and child cohort[J].Am J Clin Nutr,2018,107(5):789-798.
[23] Gerlich J,Benecke N,Peters-Weist AS,et al.Pregnancy and perinatal conditions and atopic disease prevalence in childhood and adulthood[J]. Allergy,2018,73(5):1064-1074.
[24] Liao SL,Tsai MH,Yao TC,et al.Caesarean section is associated with reduced perinatal cytokine response, increased risk of bacterial colonization in the airway, and infantile wheezing[J].Sci Rep,2017,7(1):9053.
[25] Mu M,Ye S,Bai MJ,et al.Birth weight and subsequent risk of asthma: a systematic review and meta-analysis[J].Heart Lung Circ,2014,23:511-519.
[26] Carter JH,Woolcott CG,Liu L, et al.Birth weight for gestational age and the risk of asthma in childhood and adolescence: a retrospective cohort study[J].Arch Dis Child,2019,104(2):179-183.
[27] Kim A,Lim G,Oh I,et al.Perinatal factors and the development of childhood asthma[J].Ann Allergy Asthma Immunol,2018,120(3):292-299.
[28] Slob EMA,Brew BK,Vijverberg SJH,et al.Early-life antibiotic use and risk of asthma and eczema:results of a discordant twin study[J].Eur Respir J,2020,55(4):1902021.
[29] Donovan BM,Abreo A,Ding T,et al.Dose, timing, and type of infant antibiotic use and the risk of childhood asthma[J].Clin Infect Dis,2020,70(8):1658-1665.
[30] Kuo CH,Kuo HF,Huang CH,et al.Early life exposure to antibiotics and the risk of childhood allergic diseases: an update from the perspective of the hygiene hypothesis[J].J Microbiol Immunol Infect, 2013,46(5):320-329.
[31] Tanaka K,Arakawa M,Miyake Y.Perinatal smoking exposure and risk of asthma in the first three years of life: A prospective prebirth cohort study[J].Allergol Immunopathol (Madr),2020,48(6):530-536.
[32] Wang B,Chen H,Chan YL,et al.Why do intrauterine exposure to air pollution and cigarette smoke increase the risk of asthma?[J]. Front Cell Dev Biol,2020,8:38.
[33] Brandt EB,Biagini Myers JM,Acciani TH,et al.Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility[J].J Allergy Clin Immunol,2015,136(2):295-303.
[34] Richgels PK,Yamani A,Chougnet CA,et al.Maternal house dust mite exposure during pregnancy enhances severity of house dust mite-induced asthma in murine offspring[J].J Allergy Clin Immunol,2017,140(5):1404-1415.
[35] Pennington AF,Strickland MJ,Klein M,et al.Exposure to mobile source air pollution in early-life and childhood asthma incidence: The kaiser air pollution and pediatric asthma study[J].Epidemiology, 2018,29(1):22-30.
[36] Lavigne É,Bélair MA,Rodriguez Duque D,et al.Effect modification of perinatal exposure to air pollution and childhood asthma incidence[J].Eur Respir J,2018,51(3):1701884.
[37] Jung CR,Chen WT,Tang YH,et al.Fine particulate matter exposure during pregnancy and infancy and incident asthma[J].J Allergy Clin Immunol,2019,143(6):2254-2262.
[38] Xing YF,Xu YH,Shi MH,et al.The impact of PM2.5 on the human respiratory system[J].J Thorac Dis,2016,8(1):E69-E74.
[39] Sbihi H,Tamburic L,Koehoorn M,et al.Perinatal air pollution exposure and development of asthma from birth to age 10 years[J].Eur Respir J,2016,47(4):1062-1071.
[40] Clifford S,Mazaheri M,Salimi F,et al.Effects of exposure to ambient ultrafine particles on respiratory health and systemic inflammation in children[J].Environ Int,2018,114:167-180.
[41] Lavigne E,Donelle J,Hatzopoulou M,et al.Spatiotemporal variations in ambient ultrafine particles and the incidence of childhood asthma[J].Am J Respir Crit Care Med,2019,199(12):1487-1495.
[42] Pennington AF, Strickland MJ, KleinM,et al. Exposure to mobile source air pollution in early-life and childhood asthma incidence: The kaiser air pollution and pediatric asthma study[J].Epidemiology,2018,29(1):22-30.
[43] Fu L,Yang X,Liu X,et al. Prenatal O₃ exposure increases the severity of OVA-induced asthma in offspring[J].Ecotoxicol Environ Saf,2020,188:109867.