目的 系统评价近10年中国健康儿童维生素D缺乏情况,为儿童公共卫生策略制定提供依据。方法 系统收集PubMed、EMbase、CNKI、WanFang Data及VIP数据库中近10年中国儿童维生素D缺乏情况相关的观察性研究,应用Stata14.0软件进行Meta分析。结果 共纳入21篇文献,129 283例0~18岁儿童,总维生素D严重缺乏、缺乏、不足、适宜、过量、中毒发生率依次为2.46%(1.03%~4.47%)、21.57%(13.65%~30.72%)、28.71%(20.83%~37.35%)、55.80%(42.19%~68.97%)、0.30%(0.17%~0.46%)、0.11%(0.07%~0.17%),缺乏率随着年龄增加逐渐增高,婴幼儿组最低(11.06%),青春期最高(56.14%),差异具有统计学意义(P=0.003);北方儿童维生素D缺乏率高于南方,冬、春季缺乏率高于夏、秋季,但差异均无统计学意义(P>0.05)。结论 中国健康儿童维生素D水平不容乐观,应积极采取措施改善中国儿童整体维生素D状态。
Abstract
Objective To systematically review the prevalence of vitamin D deficiency in healthy Chinese children for nearly 10 years, in order to provide data for public health strategies for children. Methods PubMed, EMbase, CNKI, WanFang Data and VIP database were searched for observational studies over the past 10 years on prevalence of vitamin D deficiency in healthy Chinese children. Stata 14.0 software was used to perform a Meta analysis on the prevalence rate. Results A total of 21 articles were reviewed, with a sample size of 129 283 children aged 0 to 18 years old. Among them, the constituent ratios of sever lacking, deficiency, insufficient, adequate, excess, intoxication were 2.46%(1.03%—4.47%), 21.57%(13.65%—30.72%), 28.71%(20.83%—37.35%), 55.80%(42.19%—68.97%), 0.30%(0.17%—0.46%) and 0.11%(0.07%—0.17%), respectively. The deficiency rate gradually increased with the increasing of age, with the lowest rate of 11.06% in the infant group and the highest rate of 56.14% in the adolescent group, the difference was statistically significant(P=0.003). The deficiency rate of children were higher in North China than in South China(P=0.249). The rate of Vitamin D deficiency in Spring and Winter were higher than that in Summer and Fall(P=0.168),but the difference was not significant(P＞0.05). Conclusion Vitamin D level in Chinese healthy children are not optimistic, and active efforts should be made to improve the overall vitamin D level of Chinese children.
关键词
维生素D /
儿童 /
中国
Key words
vitamin D /
children /
China
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基金
河北省2018年度医学科学研究重点课题(20180627)
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