目的 分析重组人生长激素治疗对特发性矮小症(ISS)患儿心理行为的影响,为临床诊治提供参考依据。方法 选择2018年1月—2019年12月在柳州市妇幼保健院儿童保健科就诊治疗的特发性矮小症患儿70例作为研究对象,随机分为治疗组和对照组,每组35例。治疗组给予重组人生长激素0.15 U/(kg·d),睡前皮下注射,两组均给予加强营养素补充,指导适当运动、充足的睡眠,保持心情愉悦,疗程均为6个月,观察两组患儿心理行为问题情况。结果 治疗后治疗组男童分裂样、多动、攻击性、违纪因子得分及女童体诉、分裂强迫因子得分较治疗前下降(t=4.465、5.053、7.064、5.804、6.815、5.112,P＜0.05),治疗组男童分裂样、多动、攻击性、违纪因子得分及女童体诉及分裂强迫因子得分低于对照组(t=-3.576、-2.551、-6.100、-2.859、-7.357、5.036,P＜0.05)。结论 重组人生长激素治疗能有效改善ISS儿童部分心理行为问题,给予重组人生长激素治疗能让ISS儿童身心发展更趋稳定和健康,从而降低其心理行为问题的发生率。

Objective To investigate the effect of recombinant human growth hormone therapy on the psychological behavior of children with idiopathic short stature (ISS),in order to provide reference for clinical treatment.Methods From January 2018 to December 2019,a total of 70 children with ISS treated in Liuzhou Maternity and Child Healthcare Hospital were randomly divided into treatment group and control group,with 35 cases in each group.The treatment group was given recombinant human growth hormone 0.15 IU/(kg·d) and injected subcutaneously before bedtime.Both groups received enhanced nutrient supplement,proper exercise,adequate sleep and good mood,and the treatment lasted for 6 months.After the treatment,the score of psychological behavior were compared between two groups.Results After treatment,the scores of split-like,hyperactivity,aggression,violation of discipline factors for boys,(t=4.465,5.053,7.064,5.804,6.815,5.112) body complaint and division forcing factor for girls (t=6.815,5.112) in the treatment group were lower than those before treatment(P<0.05).The scores of split-like,hyperactivity,aggression,violation of discipline factors for boys (t=-3.576,-2.551,-6.100,-2.859),body complaint,social retreat and division forcing factor for girls (t=-7.357,-5.036) in the treatment group were significantly lower than those in the control group after treatment (P<0.05).Conclusions Recombinant human growth hormone therapy can effectively improve some psychological and behavioral problems in ISS children.Recombinant human growth hormone therapy can make the physical and mental development of ISS children more stable and healthy,thus reducing the incidence of psychological and behavioral problems in ISS children.