目的 分析血清瘦素、网膜素-1和脂联素在女童特发性中枢性性早熟(ICPP)的诊断价值,为临床应用提供理论依据。方法 选取2017年4月—2019年8月重庆市大足区人民医院124例ICPP女童、86例单纯性乳房发育(PT)女童和100例健康女童为研究对象。用酶联免疫吸附实验检测血清瘦素、网膜素-1 和脂联素水平。受试者工作特征曲线 (ROC)曲线分析各指标在诊断及鉴别诊断中的价值,计算曲线下面积(AUC)。结果 与对照组比较,ICPP组瘦素水平较高,网膜素-1和脂联素水平较低(P＜0.05),PT组瘦素水平较高,网膜素-1水平较低(P＜0.05);与PT组比较,ICPP组瘦素水平较高,网膜素-1水平较低(P＜0.05)。瘦素、网膜素-1 和脂联素诊断ICPP的AUC分别为0.898、0.842和0.799,三者联合检测可将AUC提高至0.920;瘦素、网膜素-1 和脂联素鉴别诊断ICPP和PT的AUC分别为0.761、0.604和0.572,三者联合检测可将AUC提高至0.775。结论 血清脂肪因子瘦素、脂联素和网膜素-1在ICPP的诊断及与PT的鉴别诊断中有一定临床价值。
Abstract
Objective To investigate the diagnostic value of serum leptin,omentin-1 and adiponectin in girls with idiopathic central precocious puberty (ICPP),in order to provide evidence for the clinical application. Methods From April 2017 to August 2019,124 girls with ICPP,86 girls with premature thelarche (PT) and 100 healthy girls were selected as the study objects. The levels of serum leptin,omentin-1 and adiponectin were tested by enzyme-linked immunosorbent assay. ROC curve was used to analyze the value of each index in diagnosis and differential diagnosis,and AUC was calculated. Results Compared with the control group,the level of leptin was higher,omentin-1 and adiponectin were lower in ICPP group (P<0.05). Leptin level was higher and omentin-1 level was lower in PT group than that in control group (P<0.05). Compared with PT group,the level of leptin was higher and omentin-1 was lower in ICPP group (P<0.05). The AUC of leptin,omentin-1 and adiponectin in the diagnosis of ICPP was 0.898,0.842 and 0.799,respectively. The combined detection of the three indicators increased AUC to 0.920. The AUC of leptin,omentin-1 and adiponectin in the differential diagnosis of ICPP and PT were 0.761,0.604 and 0.572,respectively. The combined detection of the three indicators increased AUC to 0.775. Conclusion Serum adipokine leptin,adiponectin and omentum-1 have certain clinical value in the diagnosis of ICPP and the differential diagnosis between ICPP and PT.
关键词
瘦素 /
网膜素-1 /
脂联素 /
乳房早发育 /
特发性中枢性性早熟
Key words
leptin /
omentin-1 /
adiponectin /
premature thelarche /
idiopathic central precocious puberty
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