目的 分析肺部解脲脲原体(UU)感染对支气管肺发育不良(BPD)的影响,为早产儿BPD的防治提供依据。 方法 检索Pubmed、Embase、Web of Science、Cochrane Library、中国知网、万方、维普及中国生物医学数据库(CBM)8个数据库,收集关于肺部UU感染对BPD影响的队列研究,检验标本为气管内分泌物,检索时间为自建库至2020年4月15日,采用Stata 15.1软件对纳入研究进行Meta分析。 结果 共纳入21项研究,均为队列研究,其中18篇文献以生后28 d为评估结局,9篇文献以校正胎龄36周为评估结局,共包含研究对象3 039例,其中UU感染组831例,非UU感染组2 085例。随机效应模型显示,UU感染不会增加BPD的发病风险(出生后28 d评估:RR=1.69, 95%CI:1.42~2.01, 矫正胎龄36周评估:RR=1.20, 95%CI:0.91~1.58)。 结论 基于现有研究数据,不能确定UU感染是BPD的影响因素,尚需统一的BPD诊断标准以及更高质量的队列研究来探索UU感染与BPD之间的关系。
Abstract
Objective To analyze the effect of pulmonary ureaplasma urealyticum (UU) infection on bronchopulmonary dysplasia (BPD), so as to provide evidence for preventing BPD in preterm infants. Methods Eight databases including PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, Wanfang Data, VIP and China Biomedical Database (CBM) were searched to collect the cohort study on the effect of pulmonary UU infection on BPD, and the source of samples were endotracheal. The retrieval time was from the establishment of the database to April 15th, 2020. Meta-analysis was carried out by using stata 15.1 software. Results A total of 21 cohort studies were included, 18 of which assessed outcomes at the 28th days after birth, 9 of which assessed outcomes at the 36th weeks of adjusted gestational age. Totally 3 039 subjects were included, 831 of whom were in UU infection group and 2 085 were in UU non-infection group. Random effect model indicated that UU infection did not increase the risk of BPD (assessment on the 28th days after birth RR=1.69, 95%CI: 1.42 - 2.01; assessment on the adjusted gestational age of 36 weeks RR=1.20, 95%CI: 0.91 - 1.58). Conclusions Based on the existing research data, it can not be determined that UU infection is the influencing factor of BPD. A unified diagnostic standard of BPD and higher quality cohort studies are warranted to explore the relationship between UU infection and BPD.
关键词
解脲脲原体 /
支气管肺发育不良 /
新生儿慢性肺疾病 /
Meta分析
Key words
ureaplasma urealyticum /
bronchopulmonary dysplasia /
neonatal chronic lung disease /
Meta-analysis
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