稀土暴露对儿童健康影响的研究进展

王帅; 丁冶春; 张致千; 范小娜

doi:10.11852/zgetbjzz2020-1196

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中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (7) : 751-754. DOI: 10.11852/zgetbjzz2020-1196

综述

稀土暴露对儿童健康影响的研究进展

王帅, 丁冶春, 张致千, 范小娜

作者信息 +

Research advances in the effects of rare earth exposure on children's health

WANG Shuai, DING Ye-chun, ZHANG Zhi-qian, FAN Xiao-na

Author information +

文章历史 +

摘要

随着稀土的广泛开采和应用,稀土大量进入环境和食物链中,人们或高或低浓度地接触稀土的机会越来越多,不断遭受着稀土体内蓄积所带来的健康问题。儿童是国家的希望、民族的未来,正处于生长发育的关键时期,稀土暴露对儿童健康的影响一直是国内外学者研究的焦点,但目前相关总结性综述较少。本文从稀土在儿童体内的蓄积分布及其暴露引起的健康效应两方面进行综述,以便为儿童早期预防、及早发现或临床治疗稀土相关疾病提供科学依据。

Abstract

With the extensive exploitation and application of rare earths, a large number of rare earths enter the environment and the food chain, people have more and more opportunities to contact rare earths at high or low concentrations, and suffer from the health problems caused by the accumulation of rare earths in their bodies. Children are the hope of the country and the future of the nation, and are in the critical period of growth and development. The impact of rare earth exposure on children's health has been the focus of domestic and foreign scholars, but there are few relevant summary reviews at present. In order to provide scientific basis for early prevention, early detection or clinical treatment of rare earth related diseases in children, this paper reviews the accumulation and distribution of rare earth in children and the health effects caused by exposure.

导出引用

王帅, 丁冶春, 张致千, 范小娜. 稀土暴露对儿童健康影响的研究进展[J]. 中国儿童保健杂志. 2021, 29(7): 751-754 https://doi.org/10.11852/zgetbjzz2020-1196

WANG Shuai, DING Ye-chun, ZHANG Zhi-qian, FAN Xiao-na. Research advances in the effects of rare earth exposure on children's health[J]. Chinese Journal of Child Health Care. 2021, 29(7): 751-754 https://doi.org/10.11852/zgetbjzz2020-1196

中图分类号： R179

参考文献

[1] 王登红,孙艳,代鸿章,等.我国“三稀矿产”的资源特征及开发利用研究[J].中国工程科学,2019,21(1):119-127.
[2] 张苏江,张立伟,张彦文,等.国内外稀土矿产资源及其分布概述[J].无机盐工业,2020,52(1):9-16.
[3] 包田美,王丽.稀土元素的人体健康效应及环境生态效应研究进展[J].包头医学院学报,2017,33(6):136-137,140.
[4] 李小飞, 陈志彪, 陈志强,等.南方稀土采矿地土壤和蔬菜重金属含量及其健康风险评价[J].水土保持学报, 2013,27(1): 146-151.
[5] Liang Q, Yin H, Li J, et al. Investigation of rare earth elements in urine and drinking water of children in mining area.[J]. Medicine, 2018,97 (40): e12717.
[6] Abdelnour SA, Abd El-Hack ME, Khafaga AF, et al. Impacts of rare earth elements on animal health and production: Highlights of cerium and lanthan um[J].Sci Total Environ, 2019, 672(2):1021-1032.
[7] 王萍,陈子慧,黄伟雄,等.广东省居民膳食稀土暴露的双份饭研究[J].华南预防医学,2018,44(4):312-316.
[8] 刘莉,戴纪强,志强,等.稀土对人体健康损害研究进展[J].中国职业医学,2019,46(5):625-627,632.
[9] 刘丹茹,庄茂强,宗金文,等.山东省某轻稀土矿区粮食中稀土元素含量与健康风险[J].环境与健康杂志,2017,34(7):595-598.
[10] Wei B, Li Y, Li H, et al. Rare earth elements in human hair from a mining area of China[J].Ecotoxicol Environ Saf, 2013, 96(5): 118-123.
[11] 彭瑞玲,潘小川,解清.稀土矿区婴幼儿与其母亲头发中稀土含量的研究[J].中华预防医学杂志,2003,37(1):20-22.
[12] 包田美,田颖,王丽霞,等.某市稀土矿区居民镧等稀土元素水平的调查[J].中华劳动卫生职业病杂志,2018,36(2):99-101.
[13] 申秀英,许晓路,章子贵,等.饮用硝酸钐对大鼠肝肾抗氧化能力的影响[J]. 毒理学杂志, 2004, 18(3):206.
[14] Liu H, Liu H, Yang Z, et al. Bone mineral density in population long-term exposed to rare earth elements from a mining area of China[J]. Biol Trace Elem Res,2020,10(2):1007.
[15] 刘丹丹,葛昆,孙静,等.稀土化合物TbCl-3对成骨细胞系MC3T3-E1增殖、分化和矿化功能的影响[J].无机化学学报,2016,32(4):583-588.
[16] Turyanskaya A, Rauwolf M, Pichler V, et al. Detection and imaging of gadol inium accumulation in human bone tissue by micro- and submi cro-X RF[J]. Sci Rep,2020,10(1):6301.
[17] 丁冶春,蓝海英,郭有,等.钇在大鼠组织器官的分布与蓄积特征及对从业人员脂代谢的影响[J].赣南医学院学报,2015,35(6):840-843.
[18] 袁慧,孙文昌,洪云婷,等.氯化镧影响大鼠海马ATP含量、COX IV及Cyt c表达的研究[J].毒理学杂志,2020,34(1):1-5..
[19] Danezis GP, Zoidis E, Zhang P, et al. Tissue distribution of rare earth elements in wild, commercial and backyard rabbits[J].Meat Sci,2019,153(3):45-50.
[20] 葛淼华,吴小琼,高薇薇,等.嘉兴市学龄儿童体内稀土元素蓄积情况调查分析[J].中国卫生检验杂志,2020,30(7):873-876,879.
[21] 张相民,蓝小林,张玲珍,等.鼻咽癌组织稀土元素含量及分布特征[J].临床耳鼻咽喉头颈外科杂志,2016,30(5):366-369.
[22] 李韶今,张相民,刘联斌,等.赣南非小细胞肺癌与正常肺组织稀土元素含量及分布[J].江西医药2016,51(6):491-495.
[23] 刘建国,王素华,武婧,等.稀土元素生物效应研究进展[J].中国职业医学,2015,42(3):335-337.
[24] Cao B, Wu J, Xu C, et al.The accumulation and metabolism characteristics of rare earth elements in sprague-dawley rats[J].Int J Environ Res Public Health,2020,17(4):1399.
[26] Chawes BL. Low-grade disease activity in early life precedes childhood asthma and allergy[J].Dan Med J,2016, 63(8):B5272.
[26] 范广勤,刘志刚,郑辉烈,等.稀土暴露对儿童免疫功能影响的研究[J].中国公共卫生,2002,18(8):952-953.
[27] Cheng J, Cheng Z, Hu R, et al. Immune dysfunction and liver damage of mice following exposure to lanthanoids[J].Environ Toxicol, 2014, 29(1):64-73.
[28] 焦冰清,梁春来,杨辉,等.硝酸镧对大鼠免疫功能影响[J].中国食品卫生杂志,2019,31(2):99-105.
[29] 范广勤,郑辉烈,袁兆康.稀土暴露对儿童智商的影响[J].环境与健康杂志,2005,22(4):256-258.
[30] 高祥.镧对大鼠中枢神经系统神经细胞自噬水平的影响及其相关机制研究[D].沈阳:中国医科大学,2019.
[31] 胡晓宇.谷氨酸及其受体在镧所致学习记忆损伤中的作用及相关机制研究[D].沈阳:中国医科大学,2018.
[32] Mallio CA, Rovira À, Parizel PM, et al. Exposure to gadolinium and neurot oxicity: current status of preclinical and clinical studies.[J].Neuroradiol, 2020, 62(8):925-934.
[33] 范广勤,郑辉烈,刘勇,等.稀土暴露与儿童生长发育的相关性研究[J].中国公共卫生, 2003,19(11):1283-1284.
[34] 刘建国,王素华,苏鑫,等.稀土氧化钕暴露对大鼠肺泡巨噬细胞毒性及炎性因子分泌的影响[J].环境与健康杂志,2015,32(10):863-866.
[35] 王素华.稀土氧化钕致大鼠肺损伤作用机制的实验研究[D].济南:山东大学,2016.
[36] 刘建国,王素华,苏鑫,等稀土氧化钕粉尘对大鼠支气管肺泡灌洗液中白细胞介素-1和肿瘤坏死因子-α影响研究[J].中国职业医学,2015,42(4):372-377.
[37] 方善钰,王芬,李舒雅,等.稀土氯化镧逆转卵巢癌顺铂耐药细胞COC1/DDP的作用[J].广东医学,2017,38(24):3767-3771.
[38] Yang CC, Wang WY, Lin FH, et al. Rare-earth-doped calcium carbonate exposed to X-ray irradiation to induce reactive oxygen species for tumor treatment[J].Int J Mol Sci, 2019, 20(5):1148.
[39] Fan Q, Cui X, Guo H, et al. Application of rare earth-doped nanoparticles in biological imaging and tumor treatment[J].Biomater Appl,2020,35(2):237-263.
[40] 郑琳琳,刘慧颖,林黎娟,等.氯化镧对不同生长发育阶段仔鼠脑组织PI3K表达的影响[J].现代预防医学,2019,46(3):492-496.
[41] Adeel M, Lee JY, Zain M, et al. Cryptic footprints of rare earth elements on natural resources and living organisms.[J].Environ Int,2019,127(3):785-800.
[42] Dong, Hua, Jianwei, et al.Lanthanum exerts acute toxicity and histopathological changes in gill and liver tissue of rare minnow(Gobiocyprisrarus)[J].Ecot oxicology,2017, 26(9):1207-1215.
[43] 刘建国,王素华.稀土元素及其化合物对机体损害作用的研究进展[J].包头医学院学报,2015,31(6):162-163.
[44] 梁青青,席海灵,郝金奇,等.包头市区儿童尿中稀土元素浓度调查[J].环境与健康杂志, 2017,34(9):805-807.