注意缺陷多动障碍与肠道菌群的关系研究进展

王亚平; 邓岚柳; 刘芮卓; 陈立

doi:10.11852/zgetbjzz2020-0802

PDF(472 KB)

中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (8) : 865-868. DOI: 10.11852/zgetbjzz2020-0802

综述

注意缺陷多动障碍与肠道菌群的关系研究进展

王亚平, 邓岚柳, 刘芮卓综述, 陈立审校

作者信息 +

Research progress on the relationship between attention-deficit/hyperactivity disorder and gut microbiota

WANG Ya-ping, DENG Lan-liu, LIU Rui-zhuo, CHEN Li

Author information +

文章历史 +

摘要

注意缺陷多动障碍(ADHD)是儿童最常见的神经发育障碍之一,表现为与发育程度不相符的注意力不集中、多动、冲动,并伴有社交、学业等方面的功能损害。目前ADHD的病因尚不清楚,普遍认为ADHD是由遗传、环境及其交互作用共同引起的一种行为疾病,可能与额叶纹状体脑功能障碍和单胺神经递质系统功能受损有关。不同的肠道菌群可产生不同的神经递质,通过微生物-肠-脑轴的双向交流参与对中枢神经系统的调控。因此,了解肠道菌群、微生物-肠-脑轴和ADHD之间的相互作用可能为ADHD的早期干预和治疗开辟新的途径。

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in children, which is characterized by inattention, hyperactivity and impulsivity that are not consistent with the developmental level, accompanied by functional impairment in social and academic performance.At present, the etiology of ADHD is not yet clear.It is generally believed that ADHD is a kind of behavioral disease caused by genetics, environment and their interaction, which may be related to dysfunction of the fronto-striatal brain and monoamine neurotransmitter system.Different gut microbiota can produce different neurotransmitters, participating in the regulation of the central nervous system through bidirectional communication of microbiota-gut-brain axis.Therefore, it will open up a new way for early intervention and treatment of ADHD.

导出引用

王亚平, 邓岚柳, 刘芮卓, 陈立. 注意缺陷多动障碍与肠道菌群的关系研究进展[J]. 中国儿童保健杂志. 2021, 29(8): 865-868 https://doi.org/10.11852/zgetbjzz2020-0802

WANG Ya-ping, DENG Lan-liu, LIU Rui-zhuo, CHEN Li. Research progress on the relationship between attention-deficit/hyperactivity disorder and gut microbiota[J]. Chinese Journal of Child Health Care. 2021, 29(8): 865-868 https://doi.org/10.11852/zgetbjzz2020-0802

中图分类号： R749.94

参考文献

[1] Wolraich ML, Hagan JF, Allan C, et al.Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents[J].Pediatrics, 2019,144(4):e20192528.
[2] 中华医学会儿科学分会发育行为学组.注意缺陷多动障碍早期识别、规范诊断和治疗的儿科专家共识[J].中华儿科杂志, 2020,58(3):188-193.
[3] Stilling RM, Dinan TG, Cryan JF.Microbial genes, brain & behaviour-epigenetic regulation of the gut-brain axis[J].Genes Brain Behav, 2014,13(1):69-86.
[4] Dinan TG, Cryan JF.The impact of gut microbiota on brain and behaviour: implications for psychiatry[J].Curr Opin Clin Nutr Metab Care, 2015,18(6):552-558.
[5] Ming X, Chen N, Ray C, et al.A gut feeling: A hypothesis of the role of the microbiome in attention-deficit/hyperactivity disorders[J].Child Neurol Open, 2018,5.doi: 10.1177/2329048X18786799.
[6] McKeown C, Hisle-Gorman E, Eide M, et al.Association of constipation and fecal incontinence with attention-deficit/hyperactivity disorder[J].Pediatrics, 2013,132(5):e1210-e1215.
[7] Hegvik TA,Instanes JT,Haavik J, et al.Associations between attention-deficit/hyperactivity disorder and autoimmune diseases are modified by sex: a population-based cross-sectional study[J].Eur Child Adolesc Psychiatry, 2018,27(5):663-675.
[8] Prehn-Kristensen A, Zimmermann A, Tittmann L, et al.Reduced microbiome alpha diversity in young patients with ADHD[J].PLoS One, 2018,13(7):e200728.
[9] Aarts E, Ederveen T, Naaijen J, et al.Gut microbiome in ADHD and its relation to neural reward anticipation[J].PLoS One, 2017,12(9):e183509.
[10] Sandhu KV, Sherwin E, Schellekens H, et al.Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry[J].Transl Res, 2017,179:223-244.
[11] Kang SS, Kurti A, Fair DA, et al.Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring[J].J Neuroinflammation, 2014,11:156.
[12] Rodriguez A, Miettunen J, Henriksen TB, et al.Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts[J].Int J Obes (Lond), 2008,32(3):550-557.
[13] Principi N, Esposito S.Gut microbiota and central nervous system development[J].J Infect, 2016,73(6):536-546.
[14] Rivera HM, Christiansen KJ, Sullivan EL.The role of maternal obesity in the risk of neuropsychiatric disorders[J].Front Neurosci, 2015,9:194.
[15] Talge NM, Allswede DM, Holzman C.Gestational age at term, delivery circumstance, and their association with childhood attention deficit hyperactivity disorder symptoms[J].Paediatr Perinat Epidemiol, 2016,30(2):171-180.
[16] Chu SM, Tsai MH, Hwang FM, et al.The relationship between attention deficit hyperactivity disorder and premature infants in Taiwanese: a case control study[J].BMC Psychiatry, 2012,12:85.
[17] Sudo N, Chida Y, Aiba Y, et al.Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice[J].J Physiol, 2004,558(Pt 1):263-275.
[18] Culhane JF, Rauh V, McCollum KF, et al.Maternal stress is associated with bacterial vaginosis in human pregnancy[J].Matern Child Health J, 2001,5(2):127-134.
[19] Grizenko N, Shayan YR, Polotskaia A, et al.Relation of maternal stress during pregnancy to symptom severity and response to treatment in children with ADHD[J].J Psychiatry Neurosci, 2008,33(1):10-16.
[20] Park S, Kim BN, Kim JW, et al.Protective effect of breastfeeding with regard to children's behavioral and cognitive problems[J].Nutr J, 2014,13(1):111.
[21] Jacka FN, Ystrom E, Brantsaeter AL, et al.Maternal and early postnatal nutrition and mental health of offspring by age 5 years: a prospective cohort study[J].J Am Acad Child Adolesc Psychiatry, 2013,52(10):1038-1047.
[22] Konikowska K, Regulska-Ilow B, Rozanska D.The influence of components of diet on the symptoms of ADHD in children[J].Rocz Panstw Zakl Hig, 2012,63(2):127-134.
[23] Sonuga-Barke EJ, Brandeis D, Cortese S, et al.Nonpharmacological interventions for ADHD: systematic review and meta-analyses of randomized controlled trials of dietary and psychological treatments[J].Am J Psychiatry, 2013,170(3):275-289.
[24] Hawkey E, Nigg JT.Omega-3 fatty acid and ADHD: blood level analysis and meta-analytic extension of supplementation trials[J].Clin Psychol Rev, 2014,34(6):496-505.
[25] Ferreira CF, Bernardi JR, Bosa VL, et al.Correlation between n-3 polyunsaturated fatty acids consumption and BDNF peripheral levels in adolescents[J].Lipids Health Dis, 2014,13:44.
[26] Knowles SR, Nelson EA, Palombo EA.Investigating the role of perceived stress on bacterial flora activity and salivary cortisol secretion: a possible mechanism underlying susceptibility to illness[J].Biol Psychol, 2008,77(2):132-137.
[27] Strati F, Cavalieri D, Albanese D, et al.New evidences on the altered gut microbiota in autism spectrum disorders[J].Microbiome, 2017,5(1):24.
[28] Derecki NC, Cardani AN, Yang CH, et al.Regulation of learning and memory by meningeal immunity: a key role for IL-4[J].J Exp Med, 2010,207(5):1067-1080.
[29] Schans JV, Cicek R, de Vries TW, et al.Association of atopic diseases and attention-deficit/hyperactivity disorder: A systematic review and meta-analyses[J].Neurosci Biobehav Rev, 2017,74(Pt A):139-148.
[30] Allred EN, Dammann O, Fichorova RN, et al.Systemic inflammation during the first postnatal month and the risk of attention deficit hyperactivity disorder characteristics among 10 year-old children born extremely preterm[J].J Neuroimmune Pharmacol, 2017,12(3):531-543.
[31] Toto M, Margari F, Simone M, et al.Antibasal ganglia antibodies and antistreptolysin O in noncomorbid ADHD[J].J Atten Disord, 2015,19(11):965-970.
[32] Giana G, Romano E, Porfirio MC, et al.Detection of auto-antibodies to DAT in the serum: interactions with DAT genotype and psycho-stimulant therapy for ADHD[J].J Neuroimmunol, 2015,278:212-222.
[33] Partty A, Kalliomaki M, Wacklin P, et al.A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial[J].Pediatr Res, 2015,77(6):823-828.
[34] Isolauri E, Kalliomaki M, Laitinen K, et al.Modulation of the maturing gut barrier and microbiota: a novel target in allergic disease[J].Curr Pharm Des, 2008,14(14):1368-1375.
[35] Ceylan MF, Uneri OS, Guney E, et al.Increased levels of serum neopterin in attention deficit/hyperactivity disorder (ADHD)[J].J Neuroimmunol, 2014,273(1-2):111-114.
[36] Dinan TG, Stanton C, Cryan JF.Psychobiotics: a novel class of psychotropic[J].Biol Psychiatry, 2013,74(10):720-726.
[37] Edden RA, Crocetti D, Zhu H, et al.Reduced GABA concentration in attention-deficit/hyperactivity disorder[J].Arch Gen Psychiatry, 2012,69(7):750-753.