目的 考察甘孜藏族自治州0~6岁儿童血清维生素A(VitA)水平,为预防VitA相关疾病的发生提供参考依据。方法 2017年4月-2019年4月在甘孜州乡城县和稻城县对2 122名藏族儿童进行体格检查,并采用高效液相色谱法检测血清VitA的含量。结果 2 122名0~6岁儿童血清VitA平均水平为(1.05±0.27)μmol/L,亚临床缺乏率为8.15%,可疑亚临床缺乏率为45.99%。婴儿组VitA 平均水平为(0.94±0.26)μmol/L,低于幼儿组[(1.09±0.28)μmol/L]和学龄前儿童组[(1.05±0.27)μmol/L](F=15.308),海拔4 km以上VitA 平均水平为(0.96±0.19)μmol/L,低于海拔2~3 km[(0.99±0.26)μmol/L]和3~4 km[(1.12±0.27)μmol/L](F＝61.735),夏季VitA 平均水平高于其他季节(F＝52.194),差异均有统计学意义(P<0.001)。此外0~1岁组亚临床缺乏率为23.97%,高于其他年龄段(χ2=43.503,P<0.001)。Logistic回归分析结果显示海拔高度、季节和年龄对亚临床缺乏和可疑亚临床缺乏均有影响,其中随着海拔升高亚临床缺乏和可疑亚临床缺乏发生几率增大。结论 甘孜藏族自治州0~6岁儿童VitA平均水平较低,以可疑亚临床缺乏为主,VitA的缺乏与年龄、海拔、季节相关,不同年龄阶段儿童应根据当地海拔高度、不同季节补充VitA及富含VitA的食物,以预防VitA缺乏及相关疾病的发生。
Abstract
Objective To investigate the serum vitamin A (VitA) level of 0- to 6-year-old children in Ganzi Tibetan Autonomous Prefecture, so as to provide reference for the prevention of vitamin A related diseases. Methods Totally 2 122 Tibetan children were examined in Xiangcheng and Daocheng counties of Ganzi Prefecture from April 2017 to April 2019, and the content of serum VitA was detected by High Performance Liquid Chromatography. Results The average level of serum VitA in 2 122 children aged 0~6 years was (1.05±0.27)μmol/L.The subclinical deficiency rate was 8.15%, and the suspect subclinical deficiency rate was 45.99%.The average level of VitA in infant group was (0.94±0.26)μmol/L, significantly lower than that in toddlerhood group [(1.09±0.28)μmol/L] and preschool group [(1.05±0.27)μmol/L](F=15.308,P＜0.001).The average VitA level above 4 km was (0.96±0.19)μmol/L, significantly lower than that of 2-3 km [(0.99±0.26)μmol/L] and 3-4 km [(1.12±0.27)μmol/L](F=61.735,P＜0.001).The average level of VitA in summer was higher than that in other seasons(F=52.194,P＜0.001).In addition, the subclinical deficiency rate of 0-1 year old group was 23.97%,significantly higher than that of other age groups(χ2 =43.503,P＜0.001).Logistic regression analysis showed that altitude, season and age all had an influence on subclinical deficiency and suspicious subclinical deficiency, and the incidence of subclinical deficiency and suspected subclinical deficiency increased with altitude. Conclusions The average level of VitA in children aged 0-6 years in Ganzi Tibetan Autonomous Prefecture is low, mainly with suspicious subclinical deficiency.The deficiency of VitA is related to age, altitude and season.Children at different ages are suggested to take VitA supplementation and food rich in VitA according to local altitude and season to prevent VitA deficiency and related diseases.
关键词
0~6岁儿童 /
维生素A /
维生素A可疑亚临床缺乏 /
维生素A亚临床缺乏 /
海拔 /
季节
Key words
children aged 0-6 years /
vitamin A /
suspected subclinical deficiency of vitamin A /
subclinical deficiency of vitamin A /
altitude /
season
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基金
四川省卫生和计划生育科研课题资助项目(17PJ276)
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