目的 分析学龄期肥胖儿童的肺通气功能特征及与血清25羟维生素D[25-(OH)D]水平的相关性,探究维生素D对肥胖儿童肺功能的影响机制。方法 2019年1月-2020年1月期间,纳入104例6~12岁肥胖儿童,进行身高、体重测量,血清25-(OH)D检测及肺功能检查,比较维生素D缺乏、不足、适宜肥胖儿童的肺通气功能参数;采用多元线性回归分析血清25-(OH)D与肺功能参数的相关性。结果 轻中度肥胖组儿童各项肺功能参数均高于重度肥胖组,且FEF50%、MMEF的差异有统计学意义(t=2.808、2.164,P<0.05)。维生素D缺乏、不足和适宜组儿童FEV1、FVC、PEF、FEF25%、FEF50%、FEF75%的差异均具有统计学意义(F=3.988、4.758、3.142、5.186、3.478、3.220,P<0.05)。肺功能参数FEV1、FVC、PEF、FEF25%、FEF50%、FEF75%、MMEF与血清25-(OH)D水平呈线性正相关(B=0.341、0.315、0.371、0.745、0.665、0.715、0.613,P<0.05);FEV1/FVC、FEV1/FVC%与血清25-(OH)D之间未发现明显相关性。结论 血清维生素D水平与学龄期肥胖儿童的部分肺功能参数呈线性正相关,可能是肥胖儿童肺功能的保护性因素。
Abstract
Objective To analyze the characteristics of pulmonary ventilation function in school-age obese children and its correlation with serum 25-hydroxyvitamin D [25-(OH)D], and to explore the mechanism of the effect of vitamin D on the pulmonary function of obese children. Methods Totally 104 obese children aged 6-12 years were recruited from January 2019 to January 2020 to measure their height, body mass, serum 25-(OH)D level and pulmonary ventilation function.Pulmonary ventilation function parameters were compared in obese children with deficient, insufficient and appropriate serum vitamin D level.Multiple linear regression was used to analyze the correlation between serum vitamin D and pulmonary function parameters. Results The lung function parameters in mild to moderate obesity group were higher than those in severe obesity group, and the differences in FEF50% and MMEF between the two groups was significant (t=2.808,2.164, P<0.05).The difference in FEV1, FVC, PEF, FEF25%, FEF50% and FEF75% were significant among obese children with deficient, insufficient and appropriate serum vitamin D level(F=3.988, 4.758, 3.142, 5.186, 3.478, 3.220, P<0.05).Multiple linear regression showed that pulmonary function parameters FEV1, FVC, PEF, FEF25%, FEF50%, FEF75% and MMEF were positively linear correlated with serum 25-(OH)D level (B=0.341, 0.315, 0.371, 0.745, 0.665, 0.715, 0.613, P<0.05).Significant correlation was not found between FEV1/FVC, FEV1/FVC% and serum 25-(OH)D level. Conclusion There is a linear positive correlation between serum 25-(OH)D level and some lung function parameters of school-age obese children, which may be a protective factor of lung function of obese children.
关键词
儿童肥胖 /
肺功能 /
维生素D
Key words
childhood obesity /
pulmonary function /
vitamin D
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基金
北京市医院管理中心儿科学科协同发展中心专项经费资助(XTZD20180401)
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