益生菌治疗儿童营养不良研究进展

石鑫淼; 王琳

doi:10.11852/zgetbjzz2020-0524

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中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (10) : 1118-1121. DOI: 10.11852/zgetbjzz2020-0524

综述

益生菌治疗儿童营养不良研究进展

石鑫淼, 王琳

作者信息 +

Research progress on probiotics in treatment of child malnutrition

SHI Xin-miao, WANG Lin

Author information +

文章历史 +

摘要

儿童营养不良严重影响患儿健康,是全球尤其是发展中国家贫困地区亟待解决的重要公共健康问题。肠道菌群与儿童营养不良关系密切。根据肠道菌群分布特征合理补充益生菌是未来发展方向。为此,本文将肠道菌群与儿童营养不良的密切关系,以及益生菌治疗儿童营养不良最新进展综述如下。

Abstract

Children′s health can be largely affected by malnutrition.Pediatric malnutrition is still an important public health issue globally, especially in poor area.Gut microbiota is closely related to pediatric malnutrition.Appropriate supplementation of probiotics according to the distribution characteristic of gut microbiota is an orientation in future.Thus, the article aims to review the close relationship between malnutrition and gut microbiota, and the progress on the application of probiotics in treating pediatric malnutrition.

导出引用

石鑫淼, 王琳. 益生菌治疗儿童营养不良研究进展[J]. 中国儿童保健杂志. 2020, 28(10): 1118-1121 https://doi.org/10.11852/zgetbjzz2020-0524

SHI Xin-miao, WANG Lin. Research progress on probiotics in treatment of child malnutrition[J]. Chinese Journal of Child Health Care. 2020, 28(10): 1118-1121 https://doi.org/10.11852/zgetbjzz2020-0524

中图分类号： R723.13

参考文献

[1] Duggan MB.Anthropometry as a tool for measuring malnutrition impact of the new WHO growth standards and reference[J].Ann Trop Paediatr, 2010, 30 (1):1-17.
[2] Robertson RC.The gut microbiome in child malnutrition[J].Nestle Nutr Inst Workshop Ser, 2020, 93:133-144.
[3] Blanton LV, Barratt MJ, Charbonneau MR, et al.Childhood undernutrition, the gut microbiota, and microbiota-directed therapeutics[J].Science, 2016, 352(6293): 1533.
[4] 曹丹丹, 马灌楠, 董梦醒, 等.肠道菌群与儿童营养不良关系的研究进展[J].发育医学电子杂志, 2017, 5(1): 45-49, 59.
[5] World Health Organization.Levels and trends in child mortality [EB/OL].2015.http://www.who.int/maternal_child_adolescent/documents/levels_trends_child_mortality_2015/en/.
[6] 张继国, 张兵, 刘爱东, 等.西部贫困农村5岁以下儿童营养不良状况分析[J].中国健康教育, 2011, 27(6): 403-405.
[7] Bhutta ZA, Berkley JA, Bandsma RHJ, et al.Severe childhood malnutrition [J].Nat Rev Dis Primers, 2017, 3:17067.
[8] Grice EA, Segre JA.The human microbiome: our second genome[J].Annu Rev Genomics Hum Genet,2012,13:151-170.
[9] Smythe PM.Changes in intestinal bacterial flora and role of infection in kwashiorkor [J].Lancet, 1958, 2(7049):724-727.
[10] Mata LJ, Jiménez F, Gordón M, et al.Gastrointestinal flora of children with protein-calorie malnutrition [J].Am J Clin Nutr, 1972, 25(10):118-126.
[11] Monira S, Nakamura S, Gotoh K, et al.Gut microbiota of healthy and malnourished children in Bangladesh [J].Front Microbiol, 2011, 2:228.
[12] Subramanian S, Huq S, Yatsunenko T, et al.Persistent gut microbiota immaturity in malnourished Bangladeshi children[J].Nature, 2014, 510(7505):417-421.
[13] Gehrig JL, Venkatesh S, Chang HW, et al.Effects of microbiota-directed foods in gnotobiotic animals and undernourished children[J].Science, 2019, 365(6449): 4732.
[14] Elizabeth P.Starving children often don’t recover, even when fed enough.Restoring their gut bacteria could help[J].Science, 2019.DOI: 10.1126/science.aay7095.
[15] Solis B, Samartín S, Gómez S, et al.Probiotics as a help in children suffering from malnutrition and diarrhea[J].Eur J Clin Nutr, 2002, 56 (Suppl 3): 57-59.
[16] Dock DB, Latorraca MQ, Aguilar-Nascimento JE, et al.Probiotics enhance recovery from malnutrition and lessen colonic mucosal atrophy after short-term fasting in rats[J].Nutrition, 2004, 20(5): 473-476.
[17] Fuller R.Probiotics in man and animals[J].J Appl Bacteriol, 1989, 66(5): 365-378.
[18] Westerik N, Kort R, Sybesma W, et al.Lactobacillus rhamnosus probiotic food as a tool for empowerment across the value chain in Africa[J].Front Microbiol, 2018, 9: 1501.
[19] Di Stefano E, White J, Seney S, et al.A Novel millet-based probiotic fermented food for the developing world[J].Nutrients, 2017, 9(5): 529.
[20] Uganda Bureau of Statistics [UBOS] and ICF[EB/OL].2017.http://apps.who.int/gho/data/view.main.ghe2002 015-UGA?lang=en[Google Scholar].
[21] Azevedo JF, Hermes-Uliana C, Lima DP, et al.Probiotics protect the intestinal wall of morphological changes caused by malnutrition[J].An Acad Bras Cienc, 2014, 86(3): 1303-1314.
[22] Zelaya H, Haro C, Laiño J, et al.Inflammation-hemostasis relationship in infected malnourished mice: modulatory effect of Lactobacillus casei CRL 431[J].Inflamm Res, 2012, 61(7): 775-785.
[23] Shukla G, Sharma A, Bhatia R, et al.Prophylactic potential of synbiotic (Lactobacillus casei and Inulin) in malnourished murine giardiasis: an immunological and ultrastructural study[J].Probiotics Antimicrob Proteins, 2019, 11(1): 165-174.
[24] Dock DB, Aguilar-Nascimento JE, Latorraca MQ.Probiotics enhance the recovery of gut atrophy in experimental malnutrition[J].Biocell, 2004, 28(2):143-150.
[25] Aflatoonian M, Taghavi Ardakani A, Modarresi SZ, et al.The Effect of synbiotic supplementation on growth parameters in mild to moderate FTT children aged 2~5 years[J].Probiotics Antimicrob Proteins, 2020, 12(1):119-124.
[26] Kara SS, Volkan B, Erten I.Lactobacillus rhamnosus GG can protect malnourished children[J].Benef Microbes, 2019, 10(3): 237-244.
[27] Grenov B, Namusoke H, Lanyero B, et al.Effect of probiotics on diarrhea in children with severe acute malnutrition: a randomized controlled study in Uganda[J].J Pediatr Gastroenterol Nutr, 2017, 64(3): 396-403.
[28] Kerac M, Bunn J, Seal A, et al.Probiotics and prebiotics for severe acute malnutrition (PRONUT study): a double-blind efficacy randomised controlled trial in Malawi[J].Lancet, 2009, 374(9684): 136-144.
[29] Devi S, Yasoda Devi P, Prakash MS.Effect of Lactobacillus supplementation on immune status of malnourished pre-school children[J].Indian J Pediatr,1999,66(5): 663-668.
[30] Westerik N, Reid G, Sybesma W, et al.The probiotic lactobacillus rhamnosus for alleviation of helicobacter pylori-associated gastric pathology in east africa[J].Front Microbiol, 2018, 9:1873.
[31] Oberhelman RA, Gilman RH, Sheen P, et al.A placebo-controlled trial of Lactobacillus GG to prevent diarrhea in undernourished Peruvian children[J].J Pediatr, 1999, 134(1): 15-20.
[32] Suez J, Zmora N, Zilberman-Schapira G, et al.Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT[J].Cell, 2018, 174(6): 1406-1423.e16.
[33] Singh V, Yeoh SB, Chassaing B, et al.Dysregulated microbial fermentation of soluble fiber induces cholestatic liver cancer[J].Cell, 2018, 175(3): 679-694.e22.
[34] Probiotics: elixir or empty promise?[J]. The Lancet Gastroenterol Hepatol, 2019, 4(2):81.
[35] Geva-Zatorsky N, Sefik E, Kua L, et al.Mining the human gut microbiota for immunomodulatory organisms[J].Cell, 2017, 168(5): 928-943.e11.
[36] Haber AL, Biton M, Rogel N, et al.A single-cell survey of the small intestinal epithelium[J].Nature, 2017, 551(7680): 333-339.