北京地区0~3月龄婴儿超重与骨密度的关系

张骞; 万乃君

doi:10.11852/zgetbjzz2020-0261

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中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (2) : 218-221. DOI: 10.11852/zgetbjzz2020-0261

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北京地区0~3月龄婴儿超重与骨密度的关系

张骞, 万乃君

作者信息 +

Relationship between overweight and bone mineral density in infants aged 0 to 3 months in Beijing

ZHANG Qian, WAN Nai-jun

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文章历史 +

摘要

目的研究0~3月龄超重婴儿骨密度的情况,为婴儿期骨骼发育保健工作提供指导。方法纳入2019年1月-2020年1月于北京积水潭医院体检的1 052名0~3月龄婴儿进行研究。由于男女身长、体重、骨骼超声信号声速值(SOS)评估标准不同,所以分别对不同性别研究对象进行研究,按照2006年WHO《儿童发育标准》分为超重组和正常组,比较两组间骨密度差异。并对组内不同性别骨密度进行比较。结果男性、女性超重组及正常组组间SOS水平差异均无统计学意义(P>0.05);超重组内男女骨密度Z值水平及正常组内男女骨密度Z值水平差异亦均无统计学意义(t＝-1.23,-0.47,P>0.05)。结论 0~3月龄阶段,超重与骨密度尚未发现明显相关性,但尚缺少各种影响因素及年龄增长与骨密度之间关系的进一步研究,仍需更多的探索以对临床提供更好指导。

Abstract

Objective To study the relationship between bone mineral density (BMD) and overweight infant of 0-3 months, so as to provide guidance for the health care of bone development in infancy. Methods Infants aged 0-3 months who took physical examination were investigated from January 2019 to January 2020.Because of the difference on the standards for body length, weight, speed of sound (SOS) between boys and girls, the research objectives of different genders were compared seperately.According to the 2006 WHO Child Growth Standards, research objectives were divided into overweight group and normal group.The level of BMD between overweight group and normal group was compared.Then, the BMD level was compared between different genders in each group. Results There were no significant differences on the level of SOS between overweight group and normal group in boys and girls (P＞0.05).Z value did not showed significant differences between boys and girls in overweight group and normal group (t=-1.23, -0.47,P＞0.05). Conclusions No significant correlation has been found between overweight and BMD in 0 to 3-month-old children.However, further studies are warranted to explore the relationship between various influencing factors and BMD or between aging and BMD, thereby providing better guidance for clinical practice.

导出引用

张骞, 万乃君. 北京地区0~3月龄婴儿超重与骨密度的关系[J]. 中国儿童保健杂志. 2021, 29(2): 218-221 https://doi.org/10.11852/zgetbjzz2020-0261

ZHANG Qian, WAN Nai-jun. Relationship between overweight and bone mineral density in infants aged 0 to 3 months in Beijing[J]. Chinese Journal of Child Health Care. 2021, 29(2): 218-221 https://doi.org/10.11852/zgetbjzz2020-0261

中图分类号： R174

参考文献

[1] 梁伟.超声骨密度测定对婴幼儿早期佝偻病的诊断价值[J].中国临床研究, 2016, 29(1):103-105.
[2] 胡一顺,李潜,林寰东,等.跟骨定量超声骨强度在骨质疏松筛查和诊断中的价值[J].中华内科杂志,2015,54(1):27-30.
[3] Torres-Costoso A, Vlachopoulos D, Ubago-Guisado E, et al.Agreement between dual-energy X-ray absorptiometry and quantitative ultrasound to evaluate bone health in adolescents:the pro-bone study[J].Pediatr Exerc Sci, 2018, 30(4):466-473.
[4] Lobstein T, Jackson-Leach R, Moodie ML, et al.Child and adolescent obesity:part of a bigger picture[J].Lancet, 2015, 385(9986):2510-2520.
[5] 于冬梅,琚腊红,赵丽云,等.中国0～5岁儿童超重肥胖分布特征[J].中华流行病学杂志, 2018, 39(6):710-714.
[6] van der Willik EM, Vrijkotte TG, Altenburg TM, et al.Exclusively breastfed overweight infants are at the same risk of childhood overweight as formula fed overweight infants[J].Arch Dis Child, 2015, 100(10):932-937.
[7] Reifsnider E, McCormick DP, Cullen KW, et al.Randomized controlled trial to prevent infant overweight in a high-risk population[J].Acad Pediatr, 2018, 18(3):324-333.
[8] 蒋晓燕,陈艳,许俐,等.腹部肥胖同骨密度、骨矿量的相关性研究[J].中国康复理论与实践, 2008, 14(09):849-850.
[9] Cobayashi F, Lopes LA, Taddei JA.Bone mineral density in overweight and obese adolescents[J].J Pediatr, 2005, 81(4):337-342.
[10] 骆志红,肖昕.6～12月龄婴幼儿超声骨密度与血脂水平的相关性研究[J].中国儿童保健杂志, 2018, 26(9):1013-1016.
[11] Zhao Y, Qin R, Ma X, et al.Adiposity is not beneficial to bone mineral density in 0~5 year old Chinese children:The Jiangsu bone health study[J].Obes Res Clin Pract, 2020, 14(1):39-46.
[12] Kim HY, Jung HW, Hong H, et al.The role of overweight and obesity on bone health in Korean adolescents with a focus on lean and fat mass[J].J Korean Med Sci, 2017, 32(10):1633-1641.
[13] 廖新,穆亚平.5～7岁低体重和肥胖儿童身体成分特点及脂肪肌肉含量与骨密度相关性研究[J].中国实用儿科杂志, 2016, 31(4):301-304.
[14] van Leeuwen J, Koes BW, Paulis WD, et al.Differences in bone mineral density between normal-weight children and children with overweight and obesity:a systematic review and meta-analysis[J].Obes Rev, 2017, 18(5):526-546.
[15] Shapses SA, Pop LC, Wang Y.Obesity is a concern for bone health with aging[J].Nutr Res, 2017, 39:1-13.
[16] Thiele DK, Ralph J, El-Masri M, et al.Vitamin D₃ supplementation during pregnancy and lactation improves vitamin D status of the mother-infant dyad[J].J Obstet Gynecol Neonatal Nurs, 2017, 46(1):135-147.
[17] 侯江婷,邓红岩,邹秋艳,等.2172例婴幼儿维生素D营养状况及影响因素调查[J].实用预防医学, 2019, 26(4):459-461.
[18] 黄晓凤,梁和平,甄国新,等.北京市顺义区农村4～12月龄婴幼儿营养素补充剂现状调查[J].职业与健康, 2010, 26(11):1247-1249.
[19] 刘雅静.顺义区婴幼儿维生素D制剂应用情况及影响因素[J].中国当代医药, 2015, 22(16):156-158.
[20] 聂敏,王鸥,张葵,等.妊娠中晚期25-羟维生素D状况初步研究[J].中华骨质疏松和骨矿盐疾病杂志, 2009, 2(2):83-87.
[21] 刘佳,张会英,王旭,等.北京市昌平地区妊娠期妇女血清25-羟基维生素D水平的回顾性分析[J].中国实验诊断学, 2017, 21(7):1207-1208.
[22] 吴珊,范小雪,吴剑萍.6～12个月婴幼儿的骨密度情况及其影响因素调查[J].当代医学, 2019, 25(31):32-34.
[23] Benedetti MG, Furlini G, Zati A, et al.The effectiveness of hysical exercise on bone density in osteoporotic patients[J].Bio Med Res Int, 2018, 2018:1-10.
[24] Boxberger K, Reimers AK.Parental correlates of outdoor play in boys and girls aged 0 to 12-a systematic review[J].Int J Environ Res Public Health, 2019, 16(2):190-208.
[25] 王俊玲,黄思敏,梁启瑶,等.雌激素的来源及其在骨代谢中的作用[J].中国骨质疏松杂志, 2015, 21(6):729-732.
[26] 赵艳,胡幼芳,秦振英,等.江苏省0～5岁儿童骨密度水平现况研究[J].中国儿童保健杂志, 2019, 27(3):296-300.
[27] 梁嘉盛.健康体检人群体成分与骨密度的相关性分析[D].南宁:广西医科大学, 2015.
[28] 陶梅,吕昌玉.IGF-I、IGFBP-3、瘦素及脂联素与胎儿生长发育的关系[C] //专集:基层医疗机构从业人员科技论文写作培训会议,北京:中国中药杂志, 2016:1471-1474.
[29] Kaya A, Orbak Z, Polat I, et al.Leptin and neuropeptide Y levels in newborns[J].J Pediatr Endocrinol Metab, 2016, 29(1):21-25.
[30] Bonjour JP, Chevalley T, Ferrari S, et al.The importance and relevance of peak bone mass in the prevalence of osteoporosis[J].Salud Publica Mex, 2009, 51(Suppl 1):5-17.
[31] 张良芬,冯爽,闻芳.北京市海淀区海淀街道6个月内婴儿母乳喂养现状及影响因素研究[J].中国儿童保健杂志, 2016, 24(10):1081-1083.
[32] 闻芳,张良芬.北京市海淀区婴儿期夜晚睡眠-觉醒模式的纵向研究[J].中国儿童保健杂志, 2016, 24(12):1306-1308.
[33] Blanco E, Burrows R, Reyes M, et al.Breastfeeding as the sole source of milk for 6 months and adolescent bone mineral density[J].Osteoporos Int, 2017, 28(10):2823-2830.
[34] Zerofsky M, Ryder M, Bhatia S, et al.Effects of early vitamin D deficiency rickets on bone and dental health, growth and immunity[J].Matern Child Nutr, 2016, 12(4):898-907.