目的 采用Meta分析的方法综合评价血清中Vit D水平与儿童变应性鼻炎(AR)发生风险的相关性,以求为儿童AR的预防和治疗提供新思路和途径。方法 计算机检索中英文数据库中公开发表的关于血清中Vit D与儿童AR相关性的病例对照研究,检索时限至2019年5月15日。按照严格的纳入与排除标准筛选文献、交叉提取数据资料,进行Meta分析。结果 共计纳入11篇文献,共3 262名研究对象,AR组1 718名,对照组1 544名。结果显示:AR组血清中Vit D水平低于对照组的表达,差异有统计学意义(SMD=-1.31,95%CI:-1.85～-0.77,P<0.001)。AR组Vit D2水平低于对照组,差异有统计学意义(SMD=-0.17,95%CI:-0.32～-0.01,P<0.001)。AR组Vit D3水平低于对照组,差异有统计学意义(SMD=-3.09,95%CI:-3.57～-2.61,P<0.001)。以地区进行亚组分析,其实验结果异质性均有所降低,考虑不同地区饮食、光照等因素对其有一定的影响。结论 AR儿童的Vit D水平明显低于正常组,尤其以Vit D3下降明显,因此提出Vit D3缺乏可能是导致儿童AR发生的重要因素。
Abstract
Objective To evaluate the correlation between serum vitamin D(Vit D) level and the risk of allergic rhinitis (AR) in children by Meta-analysis. Methods Case-control studies on the correlation between serum Vit D level and childhood AR published till 15th May in 2019 were searched in computer databases.Literature was selected according to strict inclusion and exclusion criteria and data were cross-extracted to perform Meta-analysis. Results Totally 11 articles involving 3 262 participants were included,of whom 1 718 in AR group and 1 544 in control group.Meta-analysis results indicated that serum Vit D level in AR group were significantly higher than that in control group (SMD=-1.31,95%CI:-1.85--0.77,P<0.001).Vit D2 level of AR group was significantly lower than that of control group(SMD=-0.17,95%CI:-0.32--0.01,P<0.001).Moreover,Vit D3 level of AR group was significantly lower than that of control group(SMD=-3.09,95%CI:-3.57--2.61,P<0.001).Subgroup analysis showed the heterogeneity of the experimental results was reduced,which may be influenced by factors such as diet and lighting in different regions. Conclusion Vit D level in children with AR is significantly lower than that in control group,especially Vit D3,suggesting Vit D3 deficiency may be an important factor for AR in children.
关键词
维生素D /
变应性鼻炎 /
Meta分析
Key words
vitamin D /
allergic rhinitis /
Meta-analysis
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