小分子非编码RNAs的非经典调控方式在肥胖中的研究进展

谢寒影; 王星云; 王军; 韩树萍; 陈小慧

doi:10.11852/zgetbjzz2019-1880

PDF(539 KB)

中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (2) : 160-164. DOI: 10.11852/zgetbjzz2019-1880

综述

小分子非编码RNAs的非经典调控方式在肥胖中的研究进展

谢寒影^1,2, 王星云¹, 王军², 韩树萍¹, 陈小慧¹

作者信息 +

Research advance in unconventional regulation of small non-coding RNAs in obesity

XIE Han-ying^*, WANG Xing-yun, WANG Jun, HAN Shu-ping, CHEN Xiao-hui

Author information +

文章历史 +

摘要

肥胖是一种以脂质过度堆积为特征的慢性代谢性疾病,给人们健康带来沉重的负担。小分子非编码RNAs(miRNAs)通常可通过沉默复合体抑制转录后基因表达,在肥胖的发生发展中起重要的作用。随着研究的深入,miRNAs的非经典调控方式逐渐走入人们的视野,包括结合编码RNAs(mRNAs)5'UTR激活基因表达、于转录水平调控mRNAs、作用于非编码RNAs(ncRNAs)、调控线粒体基因、编码调节肽、作为Toll受体的配体等。这些新型非经典调控方式为miRNAs作用和机制的研究打开了新世界的大门。本文就miRNAs的非经典调控方式以及与肥胖发生相关机制展开综述。

Abstract

Obesity is a chronic metabolic disorder disease characterized by excessive fat accumulation,causing heavy burden to the health.In general,small non-coding RNAs (miRNAs) negatively regulate protein-coding gene expression at post-transcriptional level through being incorporated in RNA-induced silencing complex,which play an important role in the development of obesity.Recent studies suggest that miRNAs also can function in an unconventional manner,including interacting with the 5'untranslated region of messenger RNAs (mRNAs) and enhancing their translation,indirectly regulating mRNAs in transcriptional level,targeting on non-coding RNAs (ncRNAs),regulating mitochondrial gene translation,encoding peptides and serving as ligands for Toll-like receptors.The discovery of these unconventional roles of miRNAs opens a new promising field of miRNAs research.In this review,recent literatures on these unconventional roles of miRNAs and the mechanisms associated with obesity are summarized.

导出引用

谢寒影, 王星云, 王军, 韩树萍, 陈小慧. 小分子非编码RNAs的非经典调控方式在肥胖中的研究进展[J]. 中国儿童保健杂志. 2021, 29(2): 160-164 https://doi.org/10.11852/zgetbjzz2019-1880

XIE Han-ying, WANG Xing-yun, WANG Jun, HAN Shu-ping, CHEN Xiao-hui. Research advance in unconventional regulation of small non-coding RNAs in obesity[J]. Chinese Journal of Child Health Care. 2021, 29(2): 160-164 https://doi.org/10.11852/zgetbjzz2019-1880

中图分类号： R589.2

参考文献

[1] Gonzalez-Muniesa P,Martinez-Gonzalez MA,Hu FB,et al.Obesity[J].Nat Rev Dis Primers,2017,3:17034.
[2] Flegal KM,Kruszon-Moran D,Carroll MD,et al.Trends in obesity among adults in the United States,2005 to 2014[J].JAMA,2016,315(21):2284-2291.
[3] Reinehr T.Long-term effects of adolescent obesity:time to act[J].Nat Rev Endocrinol,2018,14(3):183-188.
[4] Bartel DP.Metazoan MicroRNAs[J].Cell,2018,173(1):20-51.
[5] Arner P,Kulyte A.MicroRNA regulatory networks in human adipose tissue and obesity[J].Nat Rev Endocrinol,2015,11(5):276-288.
[6] Treiber T,Treiber N,Meister G.Regulation of microRNA biogenesis and its crosstalk with other cellular pathways[J].Nat Rev Mol Cell Biol,2019,20(1):5-20.
[7] Elks CE,Den Hoed M,Zhao JH,et al.Variability in the heritability of body mass index:a systematic review and meta-regression[J].Front Endocrinol (Lausanne),2012,3:29.
[8] Winkler TW,Justice AE,Graff M,et al.The influence of age and sex on genetic associations with adult body size and shape:a large-scale genome-wide interaction study[J].PLoS Genet,2015,11(10):e1005378.
[9] Hodson L,Gunn PJ.The regulation of hepatic fatty acid synthesis and partitioning:the effect of nutritional state[J].Nat Rev Endocrinol,2019,15(12):689-700.
[10] Villarroya F,Cereijo R,Villarroya J,et al.Brown adipose tissue as a secretory organ[J].Nat Rev Endocrinol,2017,13(1):26-35.
[11] Ying W,Riopel M,Bandyopadhyay G,et al.Adipose tissue macrophage-derived exosomal mirnas can modulate in vivo and in vitro insulin sensitivity[J].Cell,2017,171(2):372-384,e312.
[12] Selitsky SR,Dinh TA,Toth CL,et al.Transcriptomicanalysis of chronic hepatitis b and c and liver cancer reveals microrna-mediated control of cholesterol synthesis programs[J].MBio,2015,6(6):e01500-01515.
[13] Rech M,Kuhn AR,Lumens J,et al.AntagomiR-103 and -107treatment affects cardiac function and metabolism[J].Mol Ther Nucleic Acids,2019,14:424-437.
[14] Mori MA,Ludwig RG,Garcia-Martin R,et al.Extracellular miRNAs:Frombiomarkers to mediators of physiology and disease[J].Cell Metab,2019,30(4):656-673.
[15] Ambros V.The functions of animal microRNAs[J].Nature,2004,431(7006):350-355.
[16] Sarshad AA,Juan AH,Muler AIC,et al.Argonaute-miRNAcomplexes silence target mrnas in the nucleus of mammalian stem cells[J].Mol Cell,2018,71(6):1040-1050,e1048.
[17] Sibley CR,Seow Y,Saayman S,et al.The biogenesis and characterization of mammalian microRNAs of mirtron origin[J].Nucleic Acids Res,2012,40(1):438-448.
[18] Cheloufi S,Dos Santos CO,Chong MM,et al.A dicer-independent miRNA biogenesis pathway that requires Ago catalysis[J].Nature,2010,465(7298):584-589.
[19] Niu Y,Mo D,Qin L,et al.Lipopolysaccharide-induced miR-1224 negatively regulates tumour necrosis factor-alpha gene expression by modulating Sp1[J].Immunology,2011,133(1):8-20.
[20] Hur W,Lee JH,Kim SW,et al.Downregulation of microRNA-451 in non-alcoholic steatohepatitis inhibits fatty acid-induced proinflammatory cytokine production through the AMPK/AKT pathway[J].Int J Biochem Cell Biol,2015,64:265-276.
[21] Orom UA,Nielsen FC,Lund AH.MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation[J].Mol Cell,2008,30(4):460-471.
[22] Jopling CL,Norman KL,Sarnow P.Positive and negative modulation of viral and cellular mRNAs by liver-specific microRNA miR-122[J].Cold Spring Harb Symp Quant Biol,2006,71:369-376.
[23] Li HD,Du XS,Huang HM,et al.Noncoding RNAs in alcoholic liver disease[J].J Cell Physiol,2019,doi:10.1002/jcp.28229.
[24] Dong L,Hou X,Liu F,et al.Regulation of insulin resistance by targeting the insulin-like growth factor 1 receptor with microRNA-122-5p in hepatic cells[J].Cell Biol Int,2019,43(5):553-564.
[25] Jeffries CD,Fried HM,Perkins DO.Nuclear and cytoplasmic localization of neural stem cell microRNAs[J].RNA,2011,17(4):675-686.
[26] Place RF,Li LC,Pookot D,et al.MicroRNA-373 induces expression of genes with complementary promoter sequences[J].Proc Natl Acad Sci U S A,2008,105(5):1608-1613.
[27] Younger ST,Corey DR.Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters[J].Nucleic Acids Res,2011,39(13):5682-5691.
[28] Li LC,Okino ST,Zhao H,et al.Small dsRNAs induce transcriptional activation in human cells[J].Proc Natl Acad Sci U S A,2006,103(46):17337-17342.
[29] Zhang Y,Fan M,Zhang X,et al.Cellular microRNAs up-regulate transcription via interaction with promoter TATA-box motifs[J].RNA,2014,20(12):1878-1889.
[30] Fleming TP,Watkins AJ,Velazquez MA,et al.Origins of lifetime health around the time of conception:causes and consequences[J].Lancet,2018,391(10132):1842-1852.
[31] Xiao M,Li J,Li W,et al.MicroRNAs activate gene transcription epigenetically as an enhancer trigger[J].RNA Biol,2017,14(10):1326-1334.
[32] Paugh SW,Coss DR,Bao J,et al.MicroRNAsform triplexes with double stranded dna at sequence-specific binding sites:a eukaryotic mechanism via which micrornas could directly alter gene expression[J].PLoS Comput Biol,2016,12(2):e1004744.
[33] Tang R,Li L,Zhu D,et al.Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus:evidence for a microRNA hierarchy system[J].Cell Res,2012,22(3):504-515.
[34] Maes OC,An J,Sarojini H,et al.Murine microRNAs implicated in liver functions and aging process[J].Mech Ageing Dev,2008,129(9):534-541.
[35] Zhang J,Zhang F,Didelot X,et al.Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring[J].BMC Genomics,2009,10:478.
[36] Braconi C,Kogure T,Valeri N,et al.microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer[J].Oncogene,2011,30(47):4750-4756.
[37] Li K,Wu Y,Yang H,et al.H19/miR-30a/C8orf4 axis modulates the adipogenic differentiation process in human adipose tissue-derived mesenchymal stem cells[J].J Cell Physiol,2019,234(11):20925-20934.
[38] Das S,Ferlito M,Kent OA,et al.Nuclear miRNA regulates the mitochondrial genome in the heart[J].Circ Res,2012,110(12):1596-1603.
[39] Zhang X,Zuo X,Yang B,et al.MicroRNA directly enhances mitochondrial translation during muscle differentiation[J].Cell,2014,158(3):607-619.
[40] Forrester SJ,Kikuchi DS,Hernandes MS,et al.Reactiveoxygen species in metabolic and inflammatory signaling[J].Circ Res,2018,122(6):877-902.
[41] Wang H,Zhu HQ,Wang F,et al.MicroRNA-1 prevents high-fat diet-induced endothelial permeability in apoE knock-out mice[J].Mol Cell Biochem,2013,378(1-2):153-159.
[42] Lauressergues D,Couzigou JM,Clemente HS,et al.Primary transcripts of microRNAs encode regulatory peptides[J].Nature,2015,520(7545):90-93.
[43] Liu Y,Luo B,Shi R,et al.Nonerythropoieticerythropoietin-derived peptide suppresses adipogenesis,inflammation,obesity and insulin resistance[J].Sci Rep,2015,5:15134.
[44] Fabbri M,Paone A,Calore F,et al.MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response[J].Proc Natl Acad Sci U S A,2012,109(31):E2110-2116.
[45] Coleman LG,Zou J,Crews FT.Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7[J].J Neuroinflammation,2017,14(1):22.
[46] Heil F,Hemmi H,Hochrein H,et al.Species-specific recognition ofsingle-stranded RNA via toll-like receptor 7 and 8[J].Science,2004,303(5663):1526-1529.
[47] Kim S,Park S,Kim B,et al.Toll-like receptor 7 affects the pathogenesis of non-alcoholic fatty liver disease[J].Sci Rep,2016,6:27849.
[48] Ahmad R,Kochumon S,Thomas R,et al.Increased adipose tissue expression of TLR8 in obese individuals with or without type-2 diabetes:significance in metabolic inflammation[J].J Inflamm (Lond),2016,13:38.
[49] Kapelouzou A,Giaglis S,Peroulis M,et al.Overexpression oftoll-like receptors 2,3,4,and 8 is correlated to the vascular atherosclerotic process in the hyperlipidemic rabbit model:the effect of statin treatment[J].J Vasc Res,2017,54(3):156-169.
[50] Thomou T,Mori MA,Dreyfuss JM,et al.Adipose-derived circulating miRNAs regulate gene expression in other tissues[J].Nature,2017,542(7642):450-455.