维生素A在铁缺乏及缺铁性贫血治疗中的作用

祝丹; 余文

doi:10.11852/zgetbjzz2019-1755

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中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (1) : 56-59. DOI: 10.11852/zgetbjzz2019-1755

综述

维生素A在铁缺乏及缺铁性贫血治疗中的作用

祝丹, 余文

作者信息 +

Role of vitamin A in the treatment of iron deficiency and iron deficiency anemia

ZHU Dan, YU Wen

Author information +

文章历史 +

摘要

近几年研究发现维生素A缺乏与铁缺乏具有显著的相关性,维生素A治疗缺铁性贫血和铁缺乏也取得了较好的临床效果。本文就维生素A缺乏与铁缺乏的相关性和作用机制,以及维生素A治疗缺铁性贫血的临床疗效和研究进展进行了综述,为维生素A用于儿童缺铁性贫血的防治提供依据,同时为降低我国儿童缺铁性贫血及铁缺乏的发病率提供更有效的防治措施。

Abstract

In recent years,it has been found that there is a significant correlation between vitamin A deficiency and iron deficiency.Vitamin A used to treat iron deficiency anemia and iron deficiency has achieved good clinical effect.This article reviews the correlation and mechanism between vitamin A deficiency and iron deficiency,as well as the clinical effect and research progress on vitamin A in the treatment of iron deficiency anemia,thus to provide basis for vitamin A in the treatment of iron deficiency anemia in children,and to give more effective reference for reducing the rate of iron deficiency anemia and iron deficiency.

导出引用

祝丹, 余文. 维生素A在铁缺乏及缺铁性贫血治疗中的作用[J]. 中国儿童保健杂志. 2021, 29(1): 56-59 https://doi.org/10.11852/zgetbjzz2019-1755

ZHU Dan, YU Wen. Role of vitamin A in the treatment of iron deficiency and iron deficiency anemia[J]. Chinese Journal of Child Health Care. 2021, 29(1): 56-59 https://doi.org/10.11852/zgetbjzz2019-1755

中图分类号： R556.3

参考文献

[1] 中华预防医学会儿童保健分会.婴幼儿喂养与营养指南[J].中国妇幼健康研究,2019,30(4):392-417.
[2] 赵惠君.儿童缺铁和缺铁性贫血的防治[J].实用儿科临床杂志,2012,27(3):163-165.
[3] 国务院.中国儿童发展纲要(2011-2020年)[R/OL].(2011-07-30)[2019-11-19].http://www.gov.cn/gongbao/content/2011/content_1927200.htm
[4] 中华医学会血液学分会红细胞疾病(贫血)学组.铁缺乏症和缺铁性贫血诊治和预防多学科专家共识[J].中华医学杂志,2018,98(8):2233-2237.
[5] Siu AL,US Preventive Services Task Force.Screening for iron deficiency anemia in young children:USPSTF recommendation statement[J].Pediatrics,2015,136(4):746-752.
[6] 高芳,高向东,李翔.婴幼儿缺铁性贫血与其智能发育的关系分析[J].临床医药实践,2016,25(12):909-911.
[7] 胡洪波,郭虹,石祖亮,等.缺铁性贫血患儿淋巴细胞体外增殖及细胞因子分泌水平研究[J].中国儿童保健杂志,2019,27(7):786-788.
[8] Mohus RM,Paulsen J,Gustad L,et al.Association of iron status with the risk of bloodstream infections:results from the prospective populationbased HUNT Study in Norway[J].Intensive Care Med,2018,44(8):1276-1283.
[9] Unger SL,Fenton TR,Jetty R,et al.Iron requirements in the first 2 years of life[J].Paediatrics &Child Health,2019,24(8):555-556.
[10] Villagomez A,Ramtekkar U.Iron,magnesium,vitamin d,and zinc deficiencies in children presenting with symptoms of attention-deficit/hyperactivity disorder[J].Children(Basel),2014,1(3):261-279.
[11] Serkan G,Ekinci O,Celik TJ,et al.Iron deficiency parameters in autism spectrum disorder:clinical correlates and associated factors[J].Ital J Pediatr,2017,43(1):86.
[12] 中华儿科杂志编辑委员会.儿童缺铁和缺铁性贫血防治建议[J].中国儿童保健杂志,2010,18(8):724-726.
[13] 王卫平.儿科学[M].北京:人民卫生出版社,2018.
[14] 向伟.儿童铁缺乏症及缺铁性贫血防治进展[J].中华儿科杂志,2008,46(7):507-509.
[15] 麦燕.孕期营养干预对妊娠期缺铁性贫血效果评价分析[J].中国医药导刊,2017,19(11):1111-1113.
[16] 中华医学会血液学分会红细胞疾病(贫血)学组.铁缺乏症和缺铁性贫血诊治和预防多学科专家共识[J].中华医学杂志,2018,98(28):2233-2237.
[17] 宰宇,翦耀文,高露,等.中国人群维生素A与贫血关系的Meta分析[J].营养学报,2016,38(5):438-442.
[18] Saraiva BC,Soares MC,Santos LC,et al.Iron deficiency and anemia are associated with low retinol levels in children aged 1 to 5 years[J].J Pediatr(Rio J),2014,90(6):593-599.
[19] 林良明,宋小芳,刘玉林,等.中国儿童维生素A缺乏与贫血关系分析[J].中国儿童保健杂志,2003,11(4):242-244.
[20] Hodges RE,Sauberlich HE,Canhan JE,et al.Hematopoietic studies in vitamin A deficiency[J].Am J Clin Nutr,1978,31(5):876-885.
[21] Cunha MSB,Siqueira EMA,Trindade LS,et al.Vitamin A deficiency modulates iron metabolism via ineffective erythropoiesis[J].J Nutr Biochem,2014,25(10):1035-1044.
[22] Jang JT,Green JB,John L,et al.Kinetic analysis shows that iron deficiency decreases liver vitamin A mobilization in rats[J].J Nutr,2000,130(5):1291-1296.
[23] Roodenburg AJC,West CE,Hovenier R,et al.Strategies for the prevention of iron deficiency through foods in the household[J].Nutr Rev,1997,55(6):233-239.
[24] GarcíaCasal MN,Layrisse M,Solano L,et al.Vitamin A and beta-carotene can improve nonheme iron absorption from rice,wheat and corn by humans[J].J Nutr,1998,128(3):646.
[25] 宁珂,李晖.维生素A和铁对缺铁性贫血儿童转铁蛋白受体和免疫功能的影响[J].海南医学院学报,2012,18(9):1266-1270.
[26] Andersen AB,Schmidt LK,Faurholt-Jepsen D,et al.The effect of daily consumption of the small fish Amblypharyngodon mola or added vitamin A on iron status:a randomised controlled trial among Bangladeshi children with marginal vitamin A status[J].Asia Pac J Clin Nutr,2016,25(3):464-471.
[27] Cañete A,Cano E,Muñoz-Chápuli R,et al.Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis[J].Nutrients,2017,9(2):E159.
[28] Cabezas-Wallscheid N,Buettner F,Sommerkamp P,et al.Vitamin A-retinoic acid signaling regulates hematopoietic stem cell dormancy[J].Cell,2017,169(5):807-823.
[29] Ginzburg YZ.Hepcidin-ferroportin axis in health and disease[J].Vitam Horm,2019,110:17-45.
[30] Wiseman EM,Dadon BE,Reifen R.The vicious cycle of vitamin A deficiency:a review[J].Crit Rev Food Sci Nutr,2017,57(17):3703-3714.
[31] da Cunha MSB,Campos Hankins NA,Arruda SF.Effect of vitamin A supplementation on iron status in humans:a systematic review and meta-analysis[J].Crit Rev Food Sci Nutr,2019,59(11):1767-1781.
[32] Zimmermann MB,Biebinger R,Rohner F,et al.Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron[J].Am J Clin Nutr,2006,84(3):580-586.
[33] Chen K,Xie HM,Tian W,et al.Effect of single-dose albendazole and vitamin A supplementation on the iron status of pre-school children in Sichuan,China[J].Br J Nutr,2016,115(8):1415-1423.
[34] Chen K,Zhang L,Luo H,et al.Effect of vitamin A supplements on iron metabolic homeostasis for preschoolers[J].Zhonghua Yu Fang Yi Xue Za Zhi,2014,48(1):18-22.Chinese.
[35] Zhang X,Chen K,Qu P,et al.Effect of biscuits fortified with different doses of vitamin A on indices of vitamin A status,haemoglobin and physical growth levels of pre-school children in Chongqing[J].Public Health Nutr,2010,13(9):1462-1471.
[36] 范萍,汪福玲,等.铁剂+维生素A与单纯铁剂改善铁营养状况整合Meta分析[J].中国预防医学杂志,2010,11(12):1213-1216.