微生物-肠-脑轴在新生儿缺氧缺血性脑病发病机制中的研究进展

李萌; 何学佳; 朱薇薇

doi:10.11852/zgetbjzz2019-1540

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中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (11) : 1223-1226. DOI: 10.11852/zgetbjzz2019-1540

综述

微生物-肠-脑轴在新生儿缺氧缺血性脑病发病机制中的研究进展

李萌, 何学佳, 朱薇薇

作者信息 +

Research progress on the microbiota-gut-brain axis in pathogenesis of neonatal hypoxic ischemic encephalopathy

LI Meng, HE Xue-jia, ZHU Wei-wei

Author information +

文章历史 +

摘要

新生儿缺氧缺血性脑病 (HIE) 是新生儿期有较高致残率和致死率的疾病之一。近年来研究显示,新生儿脑部的缺氧缺血性损伤与微生物-肠-脑轴参与的神经系统氧化应激和组织线粒体功能障碍有关,但其分子机制尚不明确;且HIE最关键的环节是二次能量衰竭的发生,两次能量衰竭之间的“潜伏期”就是所谓的治疗“时间窗”,是减轻脑损伤的神经保护措施能被成功应用的最佳时间。本文综述了“微生物-肠-脑轴”参与氧化应激在HIE发病机制中的研究进展,希望通过该轴作用在HIE治疗“时间窗”内,减轻氧化应激对大脑的损伤,从而为肠道菌群与大脑之间的相互作用增加一个新的维度,为HIE的防治打开一扇门。

Abstract

Neonatal hypoxic ischemic encephalopathy (HIE) is one of the diseases with high disability rate and mortality rate in the neonatal period.Recent studies have shown that the hypoxic ischemic injury of the newborn brain is related to the oxidative stress of the nervous system and mitochondrial dysfunction of tissue involved in the “microbiota-gut-brain axis”,but its molecular mechanism is still unclear.The most critical link of HIE is the occurrence of secondary energy failure,and the “latency period” between the two energy failure is the so-called “time window” for treatment,which is the best time when the neuroprotective measures to reduce brain injury can be successfully applied.This paper reviews the research progress on “microbiota-gut-brain axis” participating in oxidative stress in the pathogenesis of HIE,thereby providing a new dimension to the interaction between intestinal flora and brain,and opening a door for the prevention and treatment of HIE.

导出引用

李萌, 何学佳, 朱薇薇. 微生物-肠-脑轴在新生儿缺氧缺血性脑病发病机制中的研究进展[J]. 中国儿童保健杂志. 2020, 28(11): 1223-1226 https://doi.org/10.11852/zgetbjzz2019-1540

LI Meng, HE Xue-jia, ZHU Wei-wei. Research progress on the microbiota-gut-brain axis in pathogenesis of neonatal hypoxic ischemic encephalopathy[J]. Chinese Journal of Child Health Care. 2020, 28(11): 1223-1226 https://doi.org/10.11852/zgetbjzz2019-1540

中图分类号： R722.1

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