目的 应用生物电阻抗分析(BIA)检测杜氏肌营养不良(DMD)患儿体成分, 并比较体重指数(BMI)与体脂百分比(PBF)判定患儿超重的一致性。方法 收集2015年8月-2017年2月在河北医科大学第三医院神经肌肉病科就诊的39例男性DMD患者作为患儿组, 同期随机选取46例健康男童作为对照组。应用BIA对两组儿童进行人体成分检测。结果 两组儿童的脂肪含量、BMI差异均无统计学意义(P＞0.05)。患儿组的身高、体重、身体水分、蛋白质、无机盐、肌肉质量和基础代谢率(BMR)均低于对照组(P<0.05), 但患儿组的PBF高于对照组(P<0.05)。患儿组中PBF与年龄呈正相关关系(r=0.546, P<0.05), BMI与PBF在判定DMD患儿超重时的一致性较差(Kappa=0.352, P<0.05)。结论 相比于同年龄段同性别的健康少儿, DMD患儿的整体营养状况较差, 应用BIA比使用BMI能更加准确地评估患儿的营养状况。
Abstract
Objective To analyze the body composition of children with duchenne muscular dystrophy (DMD) by bioelectrical impedance analysis (BIA), and to compare the consistency of body mass index (BMI) with the percentage of body fat (PBF) when assessing the overweight of DMD children. Methods A total of 39 male DMD children were enrolled in case group from August 2015 to February 2017 in Neuromuscular Department of the Third Hospital of Hebei Medical University, and 46 healthy boys were randomly selected as control group during the same period.BIA was used to test body composition in two groups. Results There was no significant difference on fat content and BMI between the two groups (P＞0.05).The height, weight, body water, protein, inorganic salt, muscle mass and basal metabolic rate (BMR) of DMD children were significantly lower than those in control group (P<0.05).However, the PBF of DMD children was higher than that of the control group (P<0.05).There was positive correlation between PBF and age in DMD children (r=0.546, P<0.05).BMI was poorly consistent with PBF in determining the overweight of children with DMD (Kappa=0.352, P<0.05). Conclusions Compared with healthy children with the same age and gender, the nutritional status of DMD children is poor.BIA can more accurately assess the nutritional status of patients than using BMI.
关键词
杜氏肌营养不良 /
生物电阻抗分析 /
体脂百分比
Key words
duchenne muscular dystrophy /
bioelectrical impedance analysis /
percentage of body fat
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参考文献
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基金
2018年度省医学适用技术跟踪项目(G2018021)
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