维生素D在孤独症谱系障碍中作用机制的研究进展

杨静; 胡燕

doi:10.11852/zgetbjzz2019-1480

PDF(521 KB)

中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (12) : 1347-1350. DOI: 10.11852/zgetbjzz2019-1480

综述

维生素D在孤独症谱系障碍中作用机制的研究进展

杨静, 胡燕

作者信息 +

Research progress on the mechanism of vitamin D in autism spectrum disorders

YANG Jing, HU Yan

Author information +

文章历史 +

摘要

孤独症谱系障碍(ASD)是一种神经发育障碍性疾病,目前发病机制尚不明确,也没有确切有效的治疗措施。近年来许多研究表明维生素D对脑发育及ASD的发生发展有重要意义,本文将对近年来维生素D在ASD中作用机制的研究进展作一综述。

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder.At present,the pathogenesis of ASD is not clear,and there is no effective treatment.In recent years,many studies have shown that vitamin D plays an important role in brain development and the occurrence and development of ASD.This review combs the progress on the mechanisms of vitamin D in ASD.

导出引用

杨静, 胡燕. 维生素D在孤独症谱系障碍中作用机制的研究进展[J]. 中国儿童保健杂志. 2020, 28(12): 1347-1350 https://doi.org/10.11852/zgetbjzz2019-1480

YANG Jing, HU Yan. Research progress on the mechanism of vitamin D in autism spectrum disorders[J]. Chinese Journal of Child Health Care. 2020, 28(12): 1347-1350 https://doi.org/10.11852/zgetbjzz2019-1480

中图分类号： :R749.94

参考文献

[1] 刘贤,林穗方,陈文雄,等.中国儿童孤独症谱系障碍患病率Meta分析[J].中国儿童保健杂志,2018,26(4):402-406.
[2] Saad K,Abdel-Rahman AA,Elserogy YM,et al.Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder[J].J Child Psychol Psychiatry,2018,59(1):20-29.
[3] Cannell JJ,Autism and vitamin D[J].Med Hypotheses,2008,70(4):750-759.
[4] García-Serna AM,Morales E.Neurodevelopmental effects of prenatal vitamin D in humans:systematic review and meta-analysis[J].Mol Psychiatry,2020,25(10):2468-2481.
[5] Wang T,Shan L,Du L,et al.Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder:a systematic review and meta-analysis[J].Eur Child Adolesc Psychiatry,2016,25(4):341-350.
[6] 董涵宇,王冰,李洪华,等.孤独症谱系障碍患儿维生素D水平与孤独症核心症状相关性研究[J].中华儿科杂志,2017,55(12):916-919.
[7] Aoki Y,Watanabe T,Abe O,et al.Oxytocin′s neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism:a randomized controlled trial[J].Mol Psychiatry,2015,20(4):447-453.
[8] Stubbs G,Henley K,Green J.Autism:will vitamin D supplementation during pregnancy and early childhood reduce the recurrence rate of autism in newborn siblings?[J].Med Hypotheses,2016,88:74-78.
[9] Saad K,Abdel-Rahman AA,Elserogy YM,et al.Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children[J].Nutr Neurosci,2016,19(8):346-351.
[10] Jia F,Shan L,Wang B,et al.Fluctuations in clinical symptoms with changes in serum 25(OH) vitamin D levels in autistic children:three cases report[J].Nutr Neurosci,2019,22(12):863-866.
[11] Hazlett HC,Poe MD,Gerig G,et al.Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 years[J].Arch Gen Psychiatry,2011,68(5):467-476.
[12] Marini F,Bartoccini E,Cascianelli G,et al.Effect of 1alpha,25-dihydroxyvitamin D3 in embryonic hippocampal cells[J].Hippocampus,2010,20(6):696-705.
[13] Ali A,Cui X,Eyles D.Developmental vitamin D deficiency and autism:putative pathogenic mechanisms[J].J Steroid Biochem Mol Biol,2018,175:108-118.
[14] Ford TC,Nibbs R,Crewther DP .Glutamate/GABA+ ratio is associated with the psychosocial domain of autistic and schizotypal traits[J].PLoS ONE,2017,12(7):e0181961.
[15] Robertson CE,Ratai EM,Kanwisher N .Reduced GAB aergic action in the autistic Brain[J].Curr Biol,2016,26(1):80-85.
[16] Sikoglu EM,Navarro AAL,Starr D,et al.Vitamin D3 supplemental treatment for mania in youth with bipolar spectrum disorders[J].J Child Adolesc Psychopharmacol,2015,25(5):415-424.
[17] Kesby JP,Turner K,Alexander S,et al.Developmental vitamin D deficiency alters multiple neurotransmitter systems in the neonatal rat brain[J].Int J Dev Neurosci,2017,62:1-7.
[18] Vuillermot S,Luan W,Meyer U,et al.Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation[J].Mol Autism,2017,8(1):9-21.
[19] Patrick RP,Ames BN.Vitamin D and the omega-3 fatty acids control serotonin synthesis and action,part 2:relevance for ADHD,bipolar disorder,schizophrenia,and impulsive behavior[J].FASEB J,2015,29(6):2207-2222.
[20] Ali A,Vasileva S,Langguth M,et al.Developmental vitamin D deficiency produces behavioral phenotypes of relevance to autism in an animal model[J].Nutrients,2019,11(5):1187-1205.
[21] Zhu Y,Zhou R,Yang R,et al.Abnormal neurogenesis in the dentate gyrus of adult mice lacking 1,25-dihydroxy vitamin D3 [1,25-(OH)₂D₃][J].Hippocampus,2012,22(3):421-433.
[22] Jia F,Shan L,Wang B,et al.Bench to bedside review:possible role of vitamin D in autism spectrum disorder[J].Psychiatry Res,2018,260:360-365.
[23] Crawford JD,Chandley MJ,Szebeni K,et al.Elevated GFAP protein in anterior cingulate cortical white matter in males with autism spectrum disorder[J].Autism Res,2015,8(6):649-657.
[24] 白瑜,冯自立.维生素D受体(VDR)对中枢神经系统功能作用的研究进展[J].生命科学,2018,232(7):20-26.
[25] Cantorna MT,Snyder L,Lin YD,et al.Vitamin D and 1,25(OH)₂D regulation of T cells[J].Nutrients,2015,7(4):3011-3021.
[26] Co kun S, im ek ,Camkurt MA,et al.Association of polymorphisms in the vitamin D receptor gene and serum 25-hydroxyvitamin D levels in children with autism spectrum disorder[J].Gene,2016,588(2):109-114.
[27] Cieélińska A,Kostyra E,Chwała B,et al.Vitamin D receptor gene polymorphisms associated with childhood autism[J].Brain Sci,2017,7(9):115-126.
[28] Schmidt RJ,Hansen RL,Hartiala J,et al.Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE study[J].Early Hum Dev,2015,91(8):483-489.
[29] Lyall K,Pauls DL,Spiegelman D,et al.Pregnancy complications and obstetric suboptimality in association with autism spectrum disorders in children of the nurses′ health study II[J].Autism Res,2012,5(1):21-30.
[30] De-Regil LM,Palacios C,Lombardo LK,et al.Vitamin D supplementation for women during pregnancy[J].Sao Paulo Med J,2016,134(3):274-275.
[31] Cannell JJ.Vitamin D and autism,what′s new?[J].Rev Endocr Metab Disord,2017,18(2):183-193.
[32] Tesic D,Hawes JE,Zosky GR.Vitamin D deficiency in BALB/c mouse pregnancy increases placental transfer of glucocorticoids[J].Endocrinology,2015,156(10):3673-3679.
[33] Gasser BA,Kurz J,Dick B,et al.Steroid metabolites support evidence of autism as a spectrum[J].Behav Sci (Basel),2019,9(5):52-65.