抽动障碍相关共患病及治疗

柯钟灵; 陈燕惠

doi:10.11852/zgetbjzz2019-1413

PDF(1148 KB)

中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (9) : 1009-1012. DOI: 10.11852/zgetbjzz2019-1413

综述

抽动障碍相关共患病及治疗

柯钟灵, 陈燕惠

作者信息 +

Review on the mechanism and treatment strategies of comorbidities related to tic disorder

KE Zhong-ling, CHEN Yan-hui

Author information +

文章历史 +

摘要

抽动障碍(TD)是一种起病于儿童时期,以抽动症状为主要表现的神经发育性疾病。其临床表现多样,可伴多种共患病,共患病增加疾病的复杂性和严重性,影响患儿学习、社会适应能力、个性及心理品质的健康发展,给治疗和管理增添诸多困难。目前对于TD共患病的机制尚不明确,治疗策略亦有争议,本文旨在综述近几年国内外文献中对于TD共患病机制及治疗策略的研究,以期提高临床医生对TD相关共患病的认识。

Abstract

Tic disorder is a kind of neurodevelopmental disorder which starts in childhood and mainly presents as tic symptoms.Its clinical manifestations are diverse and can be accompanied by a variety of comorbidities.Comorbidities increase the complexity and severity of disease,affect the healthy development of children′s learning,social adaptability,personality and psychological quality,and cause many difficulties in treatment.At present,the mechanism of tic disorder comorbidity is not clear,and the treatment strategy is controversial.This paper aims to review the research on comorbidity mechanism and treatment strategy of tic disorder in recent years,so as to improve clinicians′ understanding of comorbidity related to tic disorder.

导出引用

柯钟灵, 陈燕惠. 抽动障碍相关共患病及治疗[J]. 中国儿童保健杂志. 2020, 28(9): 1009-1012 https://doi.org/10.11852/zgetbjzz2019-1413

KE Zhong-ling, CHEN Yan-hui. Review on the mechanism and treatment strategies of comorbidities related to tic disorder[J]. Chinese Journal of Child Health Care. 2020, 28(9): 1009-1012 https://doi.org/10.11852/zgetbjzz2019-1413

中图分类号： R749.94

参考文献

[1] Feinstein AR.the pre-therapeutic classification of co-morbidity in chronicdisease[J].J Chronic Dis,1970,23(7):455-468.
[2] Groth C,Mol Debes N,Rask CU,et al.Course of tourette syndrome and comorbidities in a large prospective clinical study[J].J Am Acad Child Adolesc Psychiatry,2017,56(4):304-312.
[3] Singer HS.Tics and tourette syndrome[J].Continuum (Minneap Minn),2019,25(4):936-958.
[4] 衣明纪,马遥,刘秀梅,等.儿童抽动障碍的诊断与评估:单中心10年回顾性研究[J].中华诊断学电子杂志,2013,1(1):22-26.
[5] Rizzo R,GulisanoM,Calì PV,et al.Long term clinical course of Tourette syndrome[J].Brain Dev,2012,34(8):667-673.
[6] Malhany N,Gulisano M,Rizzo R,et al.Tourette syndrome and comorbid ADHD:causes and consequences[J].Eur J Pediatr,2015,174(3):279-288
[7] bdulkadir M,Tischfield JA,King RA,et al.Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder[J].J Psychiatr Res,2016,82:126-135.
[8] Martino D,Zis P,Buttiglione M.The role of immune mechanisms in Tourette syndrome[J].Brain Res,2015,1617:126-143.
[9] Martino D,Ganos C,Pringsheim TM.Tourette syndrome and chronic tic disorders:the clinical spectrum beyond tics[J].Int Rev Neurobiol,2017,134:1461-1490.
[10] Ganos C,Martino D,Pringsheim T.Tics in the pediatric pop ulation:pragmatic management[J].Mov Disord Clin Pract,2017,4(2):160-172.
[11] Osland ST,Steeves TD,Pringsheim T.Pharmacological tre atment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders[J].Cochrane Database Syst Rev,2018,26(6):CD007990.
[12] Lisa K,Theresa S,Norbert K.Systematic review of co-occurring OCD and TD:Evidence for a tic-related OCD subtype?[J].Neurosci Biobehav Rev,2018,95:280-314.
[13] Mataix-Cols D,Frans E,Pérez-Vigil A,et al.A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette′s/chronic tic disorders[J].Mol Psychiatry,2018,23(7):1652-1658.
[14] Roessner V,Plessen KJ,Rothenberger A,et al.European clinical guidelines for Tourette syndrome and other tic disorders.Part II:Pharmacological treatment[J].Eur Child Adolesc Psychiatry,2011,20(4):173-196.
[15] Porta M,Brambilla A,Cavanna AE,et al.Thalamic deep brain stimulation for treatment-refractory tourette syndrome:two-year outcome[J].Neurology,2009,73(17):1375-1380.
[16] Sambrani T,Jakubovski E,Müller-Vahl KR.New insights into clinical characteristics of gilles de la tourette syndrome:findings in 1032 patients from a single german center[J].Front Neurosci,2016,10:415.
[17] Lee WT,Huang HL,Wong LC,et al.Tourette syndrome as an independent risk factor for subsequent sleep disorders in children:a nationwide population-based case-control Study[J].Sleep,2017,40(3).doi:1093/sleep/zsw072.
[18] Ghosh D,Rajan PV,Das D,et al.Sleep disorders in children with Tourette syndrome[J].Pediatr Neurol,2018,88:31-35.
[19] Augustine F,Singer HS.Merging the pathophysiology and pharmacotherapy of tics[J].Tremor Other Hyperkinet Mov (NY),2019,8:595.
[20] Papadopoulos N,Sciberras E,Hiscock H,et al.The efficacy of a brief behavioral sleep intervention in school-aged children with ADHD and comorbid autism spectrum disorder[J].J Atten Disord,2019,23(4):341-350.
[21] Hirschtritt ME,Lee PC,Pauls DL,et al.Lifetime prevalence,age of risk,and genetic relationships of comorbid psychiatric disorders in Tourette syndrome[J].JAMA Psychiatry,2015,72(4):325-333.
[22] Wanderer S,Roessner V,Freeman R,et al.Relationship of obsessive-comulsive disorder to age-related comorbidity in children and adolescents with Tourette syndrome[J].J Dev Behav Pediatr,2012,33(2):124-133.
[23] Ashutosh K,William T,Debra B.Tourette syndrome and comorbid neuropsychiatric conditions[J].Curr Dev Disord Rep,2016,3(4):217-221.
[24] Dale RC.Tics and tourette:a clinical,pathophysiological and etiological review[J].Curr Opin Pediatr,2017,29(6):665-673.
[25] Cubo E,Gonzalez C,Ausin V,et al.The association of poor academic performance with tic disorders:a longitudinal,mainstream school-based population study[J].Neuroepidemiology,2017,48(3-4):155-163.
[26] 刘智胜.儿童抽动障碍[M].2版.北京:人民卫生出版社,2014:145.
[27] Carias KV,Wevrick R.Clinical and genetic analysis of children with a dual diagnosis of Tourette syndrome and autism spectrum disorder[J].J Psychiatr Res,2019,111:145-153.
[28] Sharma SR,Gonda X,Tarazi FI.Autism spectrum disorder:classification,diagnosis and therapy[J].Pharmacol Ther,2018,190:91-104.
[29] Mol Debes NM.Co-morbid disorders in Tourette syndrome[J].Behav Neurol,2013,27(1):7-14.