锌、镁、铁和维生素D缺乏与儿童注意缺陷多动障碍关系的研究进展

张林, 胡斌, 张雨平 综述, 何丽

中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (8) : 875-878.

PDF(606 KB)
PDF(606 KB)
中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (8) : 875-878. DOI: 10.11852/zgetbjzz2019-1289
综述

锌、镁、铁和维生素D缺乏与儿童注意缺陷多动障碍关系的研究进展

  • 张林, 胡斌, 张雨平 综述, 何丽( 审校)
作者信息 +

Association between zinc, magnesium, iron, vitamin D deficiencies and attention deficit hyperactivity disorder

  • ZHANG Lin, HU Bin, ZHANG Yu-ping, HE Li
Author information +
文章历史 +

摘要

注意缺陷多动障碍(ADHD)是一种神经发育障碍性疾病, 发病率呈逐年上升趋势, 病因和发病机制尚不明确。虽然支持营养补充剂治疗ADHD的证据有限, 但大量研究表明ADHD患儿的锌、镁、铁和维生素D水平显著低于健康儿童。这些营养素在神经功能中均具有重要作用。因此, 本文综述了锌、镁、铁和维生素D缺乏与ADHD关系的研究进展, 鼓励医务工作者通过回顾患儿的饮食历史, 采取适当的筛查和预防性治疗措施。

Abstract

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder.The incidence of ADHD is increasing year by year.The etiology and pathogenesis are still unclear.Although there is limited evidence to support nutritional supplements in the treatment of ADHD, a large number of studies have shown that zinc, magnesium, iron and vitamin D levels in children with ADHD are significantly lower than those in healthy children.These nutrients play an important role in neurological function.Therefore, this article reviews the research progress of the relationship between zinc, magnesium, iron and vitamin D deficiency and ADHD, and encourages medical workers to take appropriate screening measures and preventive treatment by reviewing the dietary history of children.

关键词

注意缺陷多动障碍 / / / / 维生素D / 儿童

Key words

attention deficit hyperactivity disorder / zinc / magnesium / iron / vitamin D / children

引用本文

导出引用
张林, 胡斌, 张雨平 综述, 何丽. 锌、镁、铁和维生素D缺乏与儿童注意缺陷多动障碍关系的研究进展[J]. 中国儿童保健杂志. 2020, 28(8): 875-878 https://doi.org/10.11852/zgetbjzz2019-1289
ZHANG Lin, HU Bin, ZHANG Yu-ping, HE Li. Association between zinc, magnesium, iron, vitamin D deficiencies and attention deficit hyperactivity disorder[J]. Chinese Journal of Child Health Care. 2020, 28(8): 875-878 https://doi.org/10.11852/zgetbjzz2019-1289
中图分类号: :R749.94   

参考文献

[1] 王文萍, 于睿莉, 王学艳, 等.儿童期变应性疾病对注意力缺陷多动障碍的影响[J].国际儿科学杂志, 2018, 45(12):952-954.
[2] Feldman HM, Reiff MI.Attention deficit-hyperactivity disorder in children and adolescents[J].NEJM, 2014, 370(9):838-846.
[3] 李世明, 冯为, 方芳, 等.中国儿童注意缺陷多动障碍患病率Meta分析[J].中华流行病学杂志, 2018, 39(7):993-998.
[4] Kulkarni M.Attention deficit hyperactivity disorder[J].Indian J Pediatr, 2015, 82(3):267-271.
[5] Kemper KJ, Gardiner P, Birdee GS.Use of complementary and alternative medical therapies among youth with mental health concerns[J].Acad Pediatr, 2013, 13(6):540-545.
[6] Maret W, Sandstead HH.Zinc requirements and the risks and benefits of zinc supplementation[J].J Trace Elem Med Biol, 2006, 20(1):3-18.
[7] Prasad AS, Bao B.Molecular mechanisms of zinc as a pro-antioxidant mediator:clinical therapeutic implications[J].Antioixdants (Basel), 2019, 8(6):E164.
[8] Lepping P, Huber M.Role of zinc in the pathogenesis of attention-deficit hyperactivity disorder[J].CNS Drugs, 2010, 24(9):721-728.
[9] Antalis CJ, Stevens LJ, Campbell M, et al.Omega-3 fatty acid status in attention-deficit/ hyperactivity disorder[J].Prostaglandins Leukot Essent Fatty Acids, 2006, 75(4/5):299-308.
[10] Kiddie JY, Weiss MD, Kitts DD, et al.Nutritional status of children with attention deficit hyperactivity disorder:a pilot study[J].Int J Pediatr, 2010:767318.http://dx.doi-org/10.1155/2011/767318
[11] Arnold LE, Bozzolo H, Hollway J, et al.Serum zinc correlates with parent- and teacher- rated inattention in children with attention-deficit/hyperactivity disorder[J].J Child Adolesc Psychopharmacol, 2005, 15(4):628-636.
[12] 高超, 吴永利, 刘君婷, 等.血清微量元素与多动症患儿行为症状的相关性研究[J].现代生物医学进展, 2016, 16(29):5727-5729.
[13] Scassellati C, Bonvicini C, Faraone SV, et al.Review:biomarkers and attention-deficit/ hyperactivity disorder:a systematic review and meta-analyses[J].J Am Acad Child Adolesc Psychiatry, 2012, 51(10):1003-1019.
[14] Bilici M, Yldrm F, Kandil S, et al.Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder[J].Prog Neuropsychopharmacol Biol Psychiatry, 2004, 28(1):181-190.
[15] Zamora J, Velásquez A, Troncoso L, et al.Zinc in the therapy of the attention-deficit/ hyperactivity disorder in children.A preliminar randomized controlled trial[J].Arch Latinoam Nutr, 2011, 61(3):242-246.
[16] Tippairote T, Temviriyanukul P, Benjapong W, et al.Hair zinc and severity of symptoms are increased in children with attention deficit and hyperactivity disorder:a hair multi-element profile study[J].Biol Trace Elem Res, 2017, 179(2):185-194.
[17] 牟文凤, 宋金莲, 丁伟.注意缺陷多动障碍儿童体内铅、锌、铁含量的检测分析[J].中国儿童保健杂志, 2013, 21(1):106-108.
[18] McGee R, Williams S, Anderson J, et al.Hyperactivity and serum and hair zinc levels in 11-year-old children from the general population[J].Biol Psychiatry, 1990, 28(2):165-168.
[19] Kozielec T, Starobrat-Hermelin B.Assessment of magnesium levels in children with attention deficit hyperactivity disorder (ADHD)[J].Magnes Res, 1997, 10(2):143-148.
[20] Mousain-Bosc M, Roche M, Polge A, et al.Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6.I.Attention deficit hyperactivity disorders[J].Magnes Res, 2006, 19(1):46-52.
[21] 徐斌, 肖德强, 肖晶莹.学龄前儿童头发矿物元素分布及其与注意力缺陷多动障碍Conners教师用量表评分的相关性分析[J].应用预防医学, 2017, 23(4):284-288.
[22] 阿斯木古丽·克力木, 热依拉·阿不拉, 阿尔祖古丽·牙合甫.6~12岁多动症儿童体内元素水平分析[J].中国妇幼保健, 2014, 29(32):5253-5254.
[23] Huss M, Vlp A, Stauss-Grabo M.Supplementation of polyunsaturated fatty acids, magnesium and zinc in children seeking medical advice for attention-deficit/hyperactivity problems-an observational cohort study[J].Lipids Health Dis, 2010, 9:105.
[24] Akhondzadeh S, Mohammadi MR, Khademi M.Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children:a double blind and randomized trial[J].BMC Psychiatry, 2004, 4:9.
[25] Arnold LE, Hurt E, Lofthouse N.Attention-deficit/hyperactivity disorder:dietary and nutritional treatments[J].Child Adolesc Psychiatry Clin N Am, 2013, 22(30):381-402.
[26] Villagomez A, Ramtekkar U.Iron, magnesium, vitamin D, and zinc deficiencies in children presenting with symptoms of attention-deficit/hyperactivity disorder[J].Children (Basel), 2014, 1(3):261-279.
[27] 张如.淮北地区少年儿童全血中钙、镁、铁、铜和锌5种元素水平调查分析[J].国际检验医学杂志, 2017, 38(9):1269-1271.
[28] Cortese S, Angriman M, Lecendreux M, et al.Iron and attention deficit/hyperactivity disorder:What is the empirical evidence so far? A systematic review of the literature[J].Expert Rev Neurother, 2012, 12(10):1227-1240.
[29] Mahmoud MM, El-Mazary AA, Maher RM, et al.Zinc, ferritin, magnesium and copper in a group of Egyptian children with attention deficithyperactivity disorder[J].Ital J Pediatr, 2011, 37:60.
[30] Konofal E, Lecendreux M, Deron J, et al.Effects of iron su pplementation on attention deficit hyperactivity disorder in children[J].Pediatr Neurol, 2008, 38(1):20-26.
[31] 施卫萍, 季加忠.营养性缺铁性贫血与注意缺陷多动障碍的临床关系研究-258例病例分析[J].现代生物医学进展, 2007, 7(12):1863-1865.
[32] Harms LR, Eyles DW, McGrath JJ, et al.Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice[J].Behav Brain Res, 2008, 187(2):343-350.
[33] Eyles DW, Smith S, Kinobe R, et al.Distribution of the vitamin D receptor and 1α-hydroxylase in human brain[J].J Chem Neuroanat, 2005, 29(1):21-30.
[34] 汪鸿, 徐海青.婴幼儿维生素D缺乏相关疾病的研究进展[J].中国儿童保健杂志, 2014, 22(2):153-155.
[35] 李曼曼, 仰曙芬.维生素D在儿童注意力缺陷多动障碍中作用的研究进展[J].中国儿童保健杂志, 2019, 27(9):979-981.
[36] Bulut M, Selek S, Gergerlioglu HS, et al.Malondialdehyde levels in adult attention-deficit hyperactivity disorder[J].J Psychiatry Neurosci, 2007, 32(6):435-438.
[37] 王媛媛, 崔俊岭, 张会丰.儿童25羟维生素D水平与注意缺陷多动障碍关系的系统评价和Meta分析[J].中国循证儿科杂志, 2018, 13(4):248-252.
[38] Kamal M, Bener A, Ehlayel MS.Is high prevalence of vitamin D deficiency a correlate for attention deficit hyperactivity disorder? [J].Atten Defic Hyperact Disord, 2014, 6(2):73-78.
[39] 上官莉莉, 赵亚茹.注意缺陷多动障碍患儿血清25羟基维生素D水平的检测[J].中国当代儿科杂志, 2015, 17(8):837-840.
[40] Mohammadpour N, Jazayeri S, Tehrani-Doost M, et al.Eff ect of vitamin D supplementation as adjunctive therapy to methylphenidate on ADHD symptoms:a randomized, double blind, placebo-controlled trial[J].Nutr Neurosci, 2018, 21(3):202-209.

基金

重庆市社会事业与民生保障科技创新专项(cstc2017 shmsA130013)

PDF(606 KB)

Accesses

Citation

Detail

段落导航
相关文章

/