近年来,国内外对婴儿肠道菌群定植状况及其相关影响因素进行了深入的研究。肠道菌群对机体消化、代谢、免疫调节和抵抗疾病等功能发育和完善有着不可替代的作用。婴儿时期是肠道菌群建立的关键时期,分娩方式、抗生素的应用、生活习惯、外界环境、喂养方式等均对肠道菌群的建立产生影响,其中喂养方式是影响肠道菌群建立的关键因素之一。近期研究表明,肠道菌群还同大脑存在广泛的交流,包括免疫调节途径、神经内分泌途径、代谢产物途径及迷走神经途径,为进一步阐明神经精神疾病的发病机制提供思路。
Abstract
In recent years,the colonization of infant intestinal flora and its related influencing factors have been studied deeply at home and abroad.Intestinal flora plays an irreplaceable role in the development and maturation of function in digestion,metabolism,immune regulation and disease resistance.Infant period is the key period for the establishment of intestinal flora.The mode of delivery,the application of antibiotics,living habits,external environment and feeding types all affect the establishment of intestinal microflora,among which feeding mode is one of the key factors.Recent studies have shown that intestinal flora also has extensive communication with the brain,including via immune regulation pathway,neuroendocrine pathway,metabolic pathway and vagal pathway,which provides ideas for further elucidating the pathogenesis of neuropsychiatric diseases.
关键词
肠道菌群 /
喂养 /
脑肠轴
Key words
intestinal flora /
feeding /
brain-gut axis
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基金
国家自然科学基金(491040-N118032J)
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