目的 分析左乙拉西坦对良性癫痫伴中央-颞区棘波患儿的疗效观察及智力影响,为临床治疗提供科学依据。方法 选取保定市儿童医院2016年8月—2018年7月收治的60例伴中央-颞区棘波良性癫痫患儿作为研究对象,按照信封法随机分为对照组(30例)与观察组(30例),对照组采用卡马西平治疗,观察组采用左乙拉西坦治疗。比较两组的临床疗效、P300潜伏期、智力水平、视听觉刺激的注意能力以及不良反应发生率。结果 治疗后,观察组伴中央-颞区棘波良性癫痫患儿的临床总有效率高于对照组,差异有统计学意义(96.67% vs.73.33%,P＜0.05);观察组患儿治疗6个月后的P300潜伏期短于对照组,差异有统计学意义(t=3.527,P＜0.05);观察组患儿治疗后的语言智商、操作智商、总智商、视觉刺激、听觉刺激的反应控制商数、注意商数均显著高于对照组,差异有统计学意义(t=9.186、2.347、3.143、2.113、4.171、2.052、3.592,P＜0.05);两组间不良反应发生率比较,差异无统计学意义(P＞0.05)。结论 左乙拉西坦治疗能够有效控制伴中央-颞区棘波良性癫痫患儿的癫痫发作情况,对于P300潜伏期以及智力水平存在积极影响。

Objective To study the therapeutic efficacy and intellectual influence of levetiracetam on children with benign epilepsy with central-sacral spine,so as to provide scientific evidence for clinical treatment. Methods Totally 60 children with central pox epilepsy who underwent central fossa from August 2016 to July 2018 were enrolled in the study.All subjects were randomly divided into control group (n=30) and observation group (n=30) according to the envelope method.The control group was treated with carbamazepine,while the observation group was treated with levetiracetam.The clinical efficacy,P300 latency,intelligence level,visual and auditory attention,and adverse reaction rate were compared between the two groups. Results After treatment,the total clinical effective rate of the observation group was higher than that of the control group (96.67% vs.73.33%,P＜0.05).The incubation period of P300 was shorter than that of the control group,and the difference was statistically significant(t=3.527, P＜0.05).The language IQ,operational IQ,total IQ,the control quotient and attention quotient of visual stimulation and auditory stimulation in the observation group were higher than those in control group (t=9.186,2.347,3.143,2.113,4.171,2.052,3.592,P＜0.05).In terms of the incidence of adverse reactions,no significant difference was found between the two groups (P＞0.05). Conclusion Levetiracetam treatment can effectively control seizures in children with benign epilepsy with central-sacral region,and has a positive effect on P300 latency and intelligence level.