小儿维生素A(VA)缺乏和贫血都是世界公共卫生问题。由于VA 缺乏不仅会引起小儿严重眼部疾病,还可导致小儿呼吸系统、免疫系统、消化系统、血液系统、生殖系统等多个系统多种疾病的发生发展;贫血对儿童的生长发育、免疫功能、学习能力等方面也有着重要影响。许多研究已证实VA缺乏可导致小儿贫血,但具体的机制目前尚无统一说法。以下就VA引起小儿贫血的病因机制做一综述。
Abstract
Vitamin A(VA) deficiency and anemia in children are worldwide public health problems.Lack of VA will not only cause serious eye diseases in children,but also lead to the occurrence and development of many diseases in children′s respiratory system,immune system,digestive system,blood system,reproductive system and other systems.Anemia also has impact on children′s growth,immune function,learning ability and other aspects.Many studies have confirmed that the deficiency of VA can cause anemia in children,but there is no unified explanation for the specific mechanism.This review summarizes the etiology and mechanism of anemia caused by VA in children.
关键词
贫血 /
维生素A /
促红细胞生成素 /
铁调素
Key words
anemia /
vitamin A /
erythropoietin /
hepcidin
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