[1] Costello JM.A new syndrome:mental subnormality and nasal papillomata[J].Aust Paediatr J,1977,13(2):114-118. [2] Gomez-Ospina N,Kuo C,Ananth AL,et al.Respiratory system involvement in Costello syndrome[J].AM J Med Genet A,2016,170(7):1849-1857. [3] Sánchez-Montenegro C,Vilanova-Sánchez A,Barrena-Delfa S,et al.Costello syndrome and Umbilical ligament rhabdomyosarcoma in two pediatric patients:case reports and review of the literature[J].Case Rep Genet,2017:1587610.doi:10.1155/2017 /1587610. [4] Chiu AT,Leung GK,Chu YW,et al.A novel patient with an attenuated Costello syndrome phenotype due to an HRAS mutation affection affecting codon 146-Literature review and update[J].Am J Med Genet A,2017,173(4):1109-1114. [5] Gremer L,De Luca A,Merbitz-Zahradnik T,et al.Duplication of Glu37 in the switch 1 region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation[J].Hum Mol Genet,2010,19(5):790-802. [6] 张寒冰,邱正庆,王薇,等.国内首例Costello综合征患儿HRAS基因突变分析[J].基础医学与临床,2010,30(12):1274-1277.