孤独症谱系障碍儿童睡眠障碍发生机制和治疗的研究进展

赵琴; 邵智

doi:10.11852/zgetbjzz2019-0471

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中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (1) : 52-56. DOI: 10.11852/zgetbjzz2019-0471

综述

孤独症谱系障碍儿童睡眠障碍发生机制和治疗的研究进展

赵琴, 邵智

作者信息 +

Research advances on pathogenesis and interventions of sleep disorders for children with autism spectrum disorder

ZHAO Qin, SHAO Zhi

Author information +

文章历史 +

摘要

睡眠障碍是孤独症谱系障碍(autism spectrum disorder,ASD)儿童的常见共病,不仅可能加重ASD儿童自身的某些核心症状,还可能影响康复训练效果。ASD儿童睡眠障碍的确切发生机制目前暂不明确,可能与睡眠调控机制异常、ASD核心症状、共患病、躯体器质性病变、营养状况及用药等因素有关。ASD儿童的睡眠障碍目前暂无特殊有效治疗手段,家长培训联合行为干预是目前推荐的具有循证支持的干预方式。

Abstract

Sleep disorders are commonly reported comorbidities in children with autism spectrum disorder (ASD),which might not only exacerbate the core symptoms of ASD,but also adversely impact the intervention efficacy.The potential mechanism for sleep disorders of ASD is not clear so far,it might be due to the abnormal sleep regulation,ASD core symptoms,the co-occurring comorbidities,medical conditions,nutritional deficiency,and the medications commonly used.There are no specific therapeutic interventions for sleep problems of ASD currently,and parent education combined with behavioral interventions is recommended.

导出引用

赵琴, 邵智. 孤独症谱系障碍儿童睡眠障碍发生机制和治疗的研究进展[J]. 中国儿童保健杂志. 2020, 28(1): 52-56 https://doi.org/10.11852/zgetbjzz2019-0471

ZHAO Qin, SHAO Zhi. Research advances on pathogenesis and interventions of sleep disorders for children with autism spectrum disorder[J]. Chinese Journal of Child Health Care. 2020, 28(1): 52-56 https://doi.org/10.11852/zgetbjzz2019-0471

中图分类号： R749.94

参考文献

[1] Kotagal S,Broomall E.Sleep in children with autism spectrum disorder[J].Pediatr Neuro,2012,47(4):242-251.
[2] Hodge D,Carollo TM,Lewin M,et al.Sleep patterns in children with and without autism spectrum disorders:developmental comparisons[J].Res Dev Disabil,2014,35:1631-1638.
[3] Maskey M,Warnell F,Parr JR,et al.Emotional and behavioural problems in children with autism spectrum disorder[J].J Autism Dev Disord,2013,43(4):851-859.
[4] May T,Cornish K,Conduit R,et al.Sleep in high-functioning children with autism:longitudinal developmental change and associations with behavior problems[J].Behav Sleep Med,2015,13(1):2-18.
[5] Mazurek MO,Sohl K.Sleep and behavioral problems in children with autism spectrum disorder[J].J Autism Dev Disord,2016,46(6):1906-1915.
[6] Fadini CC,Lamônica DA,Fett-Conte AC,et al.Influence of sleep disorders on the behavior of individuals with autism spectrum disorder[J].Front Hum Neurosci,2015,9:347.
[7] Hundley RJ,Shui A,Malow BA.Relationship between subtypes of restricted and repetitive behaviors and sleep disturbance in autism spectrum disorder[J].J Autism Dev Disord,2016,46(11):3448-3457.
[8] Friedman A,Luiselli JK.Excessive daytime sleep:behavioral assessment and intervention in a child with autism[J].Behav Modif,2008,32(4):548-555.
[9] Singh K,Zimmerman AW.Sleep in autism spectrum disorder and attention deficit hyperactivity disorder[J].Semin Pediatr Neurol,2015,22(2):113-125.
[10] Herrmann S.Counting sheep:sleep disorders in children with autism spectrum disorders[J].J Pediatr Health Care,2016,30(2):143-154.
[11] Veatch OJ,Maxwell-Horn AC,Malow BA.Sleep in autism spectrum disorders[J].Curr Sleep Med Rep,2015,1(2):131-140.
[12] Johnson CR,DeMand A,Lecavalier L,et al.Psychometric properties of the children′s sleep habits questionnaire in children with autism spectrum disorder[J].Sleep Med,2016,20:5-11.
[13] Hirata I,Mohri I,Kato-Nishimura K,et al.Sleep problems are more frequent and associated with problematic behaviors in preschoolers with autism spectrum disorder[J].Res Dev Disabil,2016,49-50:86-99.
[14] Youssef J,Singh K,Huntington N,et al.Relationship of serum ferritin levels to sleep fragmentation and periodic limb movements of sleep on polysomnography in autism spectrum disorders[J].Pediatr Neurol,2013,49(4):274-278.
[15] Lane R,Kessler R,Buckley AW.Evaluation of periodic limb movements in sleep and iron status in children with autism[J].Pediatr Neurol,2015,53(4):343-349.
[16]Tanguay PE,Ornitz EM,Forsythe AB,et al.Rapid eye movement (REM) activity in normal and autistic children during REM sleep[J].J Autism Child Schizophr,1976,6(3):275-288.
[17] Thirumalai SS,Shubin RA,Robinson R.Rapid eye movement sleep behavior disorder in children with autism[J].J Child Neurol,2002,17(3):173-178.
[18] Botbol M,Cabon P,Kermarrec S,et al.Biological and psychological rhythms:an integrative approach to rhythm disturbances in autistic disorder[J].J Physiol Paris,2013,107(4):298-309.
[19] Veatch OJ,Keenan BT,Gehrman PR,et al.Pleiotropic genetic effects influencing sleep and neurological disorders[J].Lancet Neurol,2017,16(2):158-170.
[20] Jonsson L,Ljunggren E,Bremer A,et al.Mutation screening of melatonin-related genes in patients with autism spectrum disorders[J].BMC Med Genomics,2010,8(3):10.
[21] Veatch OJ,Sutcliffe JS,Warren ZE,et al.Shorter sleep duration is associated with social impairment and comorbidities in ASD[J].Autism Res,2017,10(7):1221-1238.
[22] McCue LM,Flick LH,Twyman KA,et al.Gastrointestinal dysfunctions as a risk factor for sleep disorders in children with idiopathic autism spectrum disorder:a retrospective cohort study[J].Autism,2017,21(8):1010-1020.
[23] Tzischinsky O,Meiri G,Manelis L,et al.Sleep disturbances are associated with specific sensory sensitivities in children with autism[J].Mol Autism,2018,9:22.
[24] Mazurek MO,Petroski GF.Sleep problems in children with autism spectrum disorder:examining the contributions of sensory over-responsivity and anxiety[J].Sleep Med,2015,16(2):270-279.
[25] Youssef J,Singh K,Huntington N,et al.Relationship of serum ferritin levels to sleep fragmentation and periodic limb movements of sleep on polysomnography in autism spectrum disorders[J].Pediatr Neurol,2013,49(4):274-278.
[26] Howes OD,Rogdaki M,Findon JL,et al.Autism spectrum disorder:consensus guidelines on assessment,treatment and research from the British association for psychopharmacology[J].J Psychopharmacol,2018,32(1):3-29.
[27] Malow BA,Byars K,Johnson K,et al.A practice pathway for the identification,evaluation,and management of insomnia in and adolescents with autism spectrum disorders[J].Pediatrics,2012,130(Suppl 2):106-124.
[28] Roberts CA,Smith KC,Sherman AK.Comparison of online and face-to-face parent education for children with autism and sleep problems[J].J Autism Dev Disord,2019,49(4):1410-1422.
[29] Delemere E,Dounavi K.Parent-implemented bedtime fading and positive routines for children with autism spectrum disorders[J].J Autism Dev Disord,2018,48(4):1002-1019.
[30] Weiskop S,Richdale A,Matthews J.Behavioural treatment to reduce sleep problems in children with autism or fragile X syndrome[J].Dev Med Child Neurol,2005,47(2):94-104.
[31]Durand VM,Gernet-Dott P,Mapstone E.Treatment of sleep disorders in children with developmental disabilities[J].The Association for Persons with Severe Handicaps,1996,21(3):114-122.
[32] Durand VM.Treating sleep terrors in children with autism[J].J PositBehav Interv,2002,4(2):66-72.
[33] DeLeon I,Fisher W,Marhefka J.Decreasing self-injurious behavior associated with awakening in a child with autism and developmental delays[J].Behav Intervent,2004,19(2):111-119.
[34] Sanberg SA,Kuhn BR,Kennedy AE.Outcomes of a behavioral intervention for sleep disturbances in children with autism spectrum disorder[J].J Autism Dev Disord,2018,48(12):4250-4277.
[35] Piazza CC,Hagopian LP,Hughes CR,et al.Using chronotherapy to treat severe sleep problems:a case study[J].Am J Ment Retard,1998,102(4):358-366.
[36] Malow BA,Katz T,Reynolds AM,et al.Sleep difficulties and medications in children with autism spectrum disorders:a registry study[J].Pediatrics,2016,137(Suppl 2):98.
[37] Rossignol DA,Frye RE.Melatonin in autism spectrum disorders:a systematic review and meta-analysis[J].Dev Med Child Neurol,2011,53(9):783-792.
[38] Malow B,Adkins KW,McGrew SG,et al.Melatonin for sleep in children with autism:a controlled trial examining dose,tolerability,and outcomes[J].J Autism Dev Disord,2012 42(8):1729-1737.
[39] McLay LL,France K.Empirical research evaluating non-traditionala pproaches to managing sleep problems in children with autism[J].Dev Neurorehabil,2016,19(2):123-134.
[40] Narasingharao K,Pradhan B,Navaneetham J.Efficacy of structured yoga intervention for sleep,gastrointestinal andbehaviour problems of asd children:an exploratory study[J].J Clin Diagn Res,2017,11(3):VC01-VC06.