目的 调查抚顺地区0~14岁儿童血清维生素A水平状况,为本地区儿童合理补充维生素A提供依据,为临床工作提供参考。方法 对2015年1月-2018年12月在辽健集团抚矿总医院儿科保健门诊健康体检的6 766例0~14岁儿童采用高效液相色谱法测定血清维生素A水平。结果 亚临床维生素A缺乏检出率为17.85%(1 208/6 766),可疑亚临床维生素A缺乏检出率为43.26%(2 927/6 766)。近四年儿童血清维生素A水平比较差异有统计学意义(P<0.05),2018年可疑亚临床维生素A缺乏检出率为45.3%,亚临床维生素A缺乏检出率为10.5%,已较前明显下降。不同性别儿童血清维生素A水平差异无统计学意义(P>0.05)。不同季节检测儿童血清维生素A水平差异有统计学意义(P<0.05),秋季儿童血清维生素A水平高于其他季节。不同年龄组儿童血清维生素A水平差异有统计学意义(P<0.05)。随年龄增长血清维生素A缺乏检出率逐渐下降,≤1月组及1~6月组血清维生素A水平明显低于其他年龄组,6~14岁组儿童血清维生素A平均水平在正常范围。结论 抚顺地区0~14岁儿童血清维生素A水平普遍偏低,0~6月龄婴儿的维生素A营养状况问题较为严重。应注意调整膳食结构,合理补充维生素A,预防维生素A缺乏症的发生。

Objective To investigate the serum level of vitamin A in children aged 0 to 14 years in Fushun city,so as to provide reasonable scientific basis for vitamin A supplementation and reference for clinical diagnosis and treatment. Methods Totally 6 766 healthy children aged 0 to 14 years,who took physical examination in Fushun Mining Bureau General Hospital,were recruited in this study from January,2015 to December,2018.Serum vitamin A level was tested by high performance liquid chromatography. Results The detection rates of subclinical vitamin A deficiency and suspicious subclinical vitamin A deficiency were 17.85% (1 208/6 766) and 43.26%(2 927/6 766).There was significantly difference on serum vitamin A level from 2015 to 2018(P＜0.05).The detection rates of suspicious subclinical vitamin A deficiency and subclinical vitamin A deficiency were 45.3% and 10.5%,respectively,significantly lower than before.There was no significant difference on serum vitamin A level between boys and girls (P＞0.05).But significant difference existed among different seasons(P＜0.05),and vitamin A level was highest in autumn.There was also significant difference on serum level of vitamin A among different age groups (P<0.05).Serum vitamin A deficiency rate gradually decreased with the increasing of age.Serum level of vitamin A in children under 1 month old and aged 1 to 6 months was significantly lower than that in other age groups.However,vitamin A level of children aged 6 to 14 years was in the normal range. Conclusions Serum vitamin A level of children aged 0 to 14 years in Fushun is still lower,especially in infants aged 0 to 6 months.Thus,more attention should be paid to the dietary structure adjustment and rational vitamin A supplementation in order to prevent vitamin A deficiency.