目的 分析哮喘患儿外周血半胱胺酰白三烯(Cys LTs)、单核细胞趋化蛋白-4(MCP-4)、巨噬细胞衍生趋化因子(MDC)表达及其临床应用价值。方法 以2016年6月-2018年6月在青岛大学附属市立医院就诊的220例儿童为研究对象,48例哮喘急性期儿童为哮喘急性发作组,52例哮喘缓解期儿童为哮喘缓解期,64例肺炎儿童为肺炎组,56例健康儿童为对照组,比较各组Cys LTs、MCP-4及MDC血清水平。结果 Cys LTs、MCP-4、MDC血清水平哮喘急性发作组均高于缓解期、肺炎组及正常对照组(P<0.05);肺炎组与哮喘缓解期间差异无统计学意义(P>0.05),但均高于正常对照组,差异均有统计学意义(P＜0.05);不同严重程度哮喘儿童外周血Cys LTs、MCP-4、MDC水平间歇组、轻度组及中重度组依次升高,两两比较差异均有统计学意义(P＜0.05);Cys LTs、MDC与MCP-4;Cys LTs 与 MDC均呈正相关(r=0.865、0.812、0.893,P＜0.01)。结论 Cys LTs、MCP-4及MDC参与了哮喘的多个环节,外周血Cys LTs、MCP-4及MDC对儿童哮喘病情评估有重要的临床应用价值。
Abstract
Objective To investigate the levels of cysteinyl leukotrienes(Cys LTs),monocyte chemoattractant protein-4(MCP-4) and macrophage-derived chemokine(MDC) in peripheral blood of asthma children,in order to explore their value in clinical assessment of asthma. Methods Totally 220 children were enrolled in this study from June 2016 to June 2018,including 48 cases in asthma attack group,52 cases in asthma remission period,64 pneumonia children and 56 healthy children.Serum levels of Cys LTs,MCP-4 and MDC in each group were compared. Results Serum levels of Cys LTs,MCP-4 and MDC in acute stage of asthma were significantly higher than those in remission stage, pneumonia group and normal control group(P＜0.05).There was no significant difference on serum levels of Cys LTs,MCP-4,MDC between pneumonia group and asthma remission group(P>0.05),which were significantly higher than those in normal control group(P< 0.05).The levels of Cys LTs,MCP-4 and MDC in peripheral blood of children with different severity categories of asthma were significantly higher than those of normal control group(P<0.05).Pearson analysis indicated that there were positive correlations between the levels of Cys LTs and MCP-4,MDC and MCP-4,Cys LTs and MDC(r=0.865,0.812,0.893,P＜0.01). Conclusions Cys LTs,MCP-4 and MDC are involved in many aspects of asthma. Cys LTs,MCP-4 and MDC in peripheral blood have important clinical value in the assessment of asthma in children.
关键词
哮喘 /
半胱胺酰白三烯 /
单核细胞趋化蛋白-4 /
巨噬细胞衍生趋化因子
Key words
asthma /
cysteamine leukotriene /
monocyte chemoattractant protein-4 /
macrophage-derived chemokine
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