益生菌预防早产儿坏死性小肠结肠炎的研究进展

冯梦妮; 柯华; 李占魁; 张莉

doi:10.11852/zgetbjzz2019-0070

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中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (6) : 629-632. DOI: 10.11852/zgetbjzz2019-0070

综述

益生菌预防早产儿坏死性小肠结肠炎的研究进展

冯梦妮¹, 柯华² 综述, 李占魁², 张莉² 审校

作者信息 +

Research progress on probiotics in preventing necrotizing enterocolitis in premature infants

FENG Meng-ni¹, KE Hua², LI Zhan-kui², ZHANG Li²

Author information +

文章历史 +

摘要

坏死性小肠结肠炎(NEC)是新生儿期一种极为严重的获得性胃肠道疾病,尤其多见于早产儿。因其发病率、死亡率以及预后不良风险较高,多年来一直备受关注,但其发病机制尚不完全清楚。近年来,有较多的研究指出肠道微生态失调与该疾病的发生密切相关,而益生菌作为一种调节肠道微生态的生物制剂逐渐受到研究者的重视。本文就新生儿肠道菌群特点及益生菌在预防早产儿NEC的相关研究热点作一综述。

Abstract

Necrotizing enterocolitis (NEC) is an extremely serious acquired gastrointestinal disease in the neonatal period,especially in premature infants.Because of its high morbidity,mortality and high risk of poor prognosis,NEC has been receiving much attention for many years,but its pathogenesis has not been fully understood.In recent years,there have been many studies pointing out that intestinal micro-ecological disorders are closely related to the occurrence of the disease.And probiotic,as a biological agent regulating intestinal micro-ecology,has gradually attracted the attention of researchers.This review summarizes the characteristics of neonatal intestinal flora and the research hotspots of probiotics in preventing NEC in premature infants.

导出引用

冯梦妮, 柯华, 李占魁, 张莉. 益生菌预防早产儿坏死性小肠结肠炎的研究进展[J]. 中国儿童保健杂志. 2019, 27(6): 629-632 https://doi.org/10.11852/zgetbjzz2019-0070

FENG Meng-ni, KE Hua, LI Zhan-kui, ZHANG Li. Research progress on probiotics in preventing necrotizing enterocolitis in premature infants[J]. Chinese Journal of Child Health Care. 2019, 27(6): 629-632 https://doi.org/10.11852/zgetbjzz2019-0070

中图分类号： R722.1

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