随着社会的发展及生活水平的改善,肥胖成为了国际热点的话题,国际肥胖特别工作组指出,肥胖将会成为21世纪危害人类健康和生活满意度最大的敌人。儿童期超重肥胖,不仅可以导致成年疾病的发生,而且是哮喘发生的重要危险因素。近年的研究表明,肥胖和哮喘在疾病的发生发展中两者相互作用、相互影响,两者的患病率也存在平行关系。肥胖型哮喘作为一个独特的哮喘表型,其具体发病机制尚未明确,本文将从慢性炎性损伤、胰岛素抵抗、代谢综合征、菌群失调、维生素D缺乏、遗传基因方面综述肥胖型哮喘可能的发病机制,以期为临床提供参考。
Abstract
With the development of society and improvement of living standards, obesity has become a hot topic in the international arena. The International Task Force on Obesity points out that “obesity will become the greatest enemy of human health and life satisfaction in the 21st century” as a national backup for development. Childhood overweight and obesity not only lead to diesase in adults, but also increase the risk of asthma. Recent studies showed obesity and asthma interacted with each other in the development of the disease, and there is also a parallel relationship between the prevalence of obesity and asthma.Obesity asthma is the most unique asthma phenotype, but its specific pathogenesis is not clear yet. This review describes possible pathogenesis mechanism of obesity asthma from chronic inflammatory injury, insulin resistance, metabolic syndrome, dysbacteriosis, vitamin D deficiency and genetic genes, in order to provide reference for clinical practice.
关键词
肥胖 /
哮喘 /
机制 /
进展
Key words
obesity /
asthma /
mechanism /
progress
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