铁缺乏是当今世界最常见的公共卫生问题之一,是发展中国家儿童中最常见的单一营养素缺乏。无论是否发展到贫血,铁缺乏会对儿童的神经发育和行为造成不可逆的损伤,因此,儿科医生和卫生保健工作者做到提前预防,早期发现,早期诊断,对于尚处于生长发育期的儿童群体具有重要意义。血清可溶性转铁蛋白受体(soluble transferrin receptor,sTfR)在缺铁早期发生变化,比较灵敏,不易受到炎症等因素的影响,与一些传统指标比较,对于早期亚临床铁缺乏的诊断具有其独特的优势。本文对血清可溶性转铁蛋白受体诊断儿童铁缺乏的研究进行综述,旨为应用sTfR诊断儿童早期铁缺乏提供参考。
Abstract
Iron deficiency (ID) continues to be a public health concern worldwide. Among children in the developing world, ID is the most common single-nutrient deficiency, with potentially severe consequences on child neurodevelopment and behavior. Therefore, pediatricians and other healthcare providers should strive to eliminate iron deficiency, the early diagnosis and treatment of the ID are of great value. Soluble transferrin receptor (sTfR) is sensitive to the inadequate delivery of iron to bone marrow and tissue, and is not affected by inflammation. Compared with other methods for screening for ID, sTfR has unique advantage. This review summarizes the use of sTfR for the diagnosis of ID in children, in order to provide reference for early diagnosis of ID in children.
关键词
铁缺乏 /
血清可溶性转铁蛋白受体 /
ROC曲线 /
儿童
Key words
iron deficiency /
soluble transferrin receptor /
ROC curve /
children
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基金
国家重点基础研究发展计划(2012CB525001)
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