目的 探索网膜素-1与儿童非酒精性脂肪肝(NAFLD)的相关性,为儿童脂肪肝的防治提供参考。方法 将116名肥胖儿童分为肥胖伴脂肪肝组(61名)、肥胖不伴脂肪肝组(55名),同时选择正常体重儿童55名作为对照组,对每位儿童进行身高、体重、腰围、血压等测量,并行血脂、血糖、肝功等化验,留取静脉血清标本测血清胰岛素、网膜素-1、瘦素、脂联素水平等,判断三组间指标差异及网膜素-1与其他指标相关性。采用Logistics回归判断有无脂肪肝与其他指标的关系,采用ROC曲线评估腰围、体重指数(BMI)、网膜素-1水平对儿童脂肪肝诊断标准有无价值。结果 血清网膜素-1在肥胖伴脂肪肝患儿中水平较另两组水平低(P<0.05)。矫正年龄及腰围后网膜素-1与有无合并脂肪肝、瘦素/脂联素(LAR)、低密度脂蛋白胆固醇(LDL-C)为负相关,与脂联素呈正相关(P<0.05)。Logistics回归分析发现BMI、胰岛素抵抗指数(HOMA-IR)为脂肪肝的危险因素,网膜素-1为脂肪肝的保护因素。腰围、BMI、血清网膜素-1水平对儿童脂肪肝诊断有一定价值。结论 血清网膜素-1水平与儿童中心性肥胖、脂代谢紊乱及脂肪肝密切相关,在儿童脂肪肝的发病中有保护作用。
Abstract
Objective To evaluate the associations between omentin-1 and childhood non-alcoholic fatty liver disease (NAFLD). Methods A total of 116 obese children were divided into NAFLD with obesity (n=61) and without obesity(n=55) group, and 55 children with normal weight were as control. The height, weight, waist circumference and blood pressure were measured.The blood lipid, blood glucose and biochemical test were also tested. Venous blood was collected to detect serum insulin, omentin-1,leptin and adiponectin and analyze the correlation. Logistics regression analysis was used to evaluate the risk and protected factors of NAFLD. And ROC curve was used to assess diagnostic value of omentin-1, body mass index(BMI)and waist circumference for NAFLD. Results Serum omentin-1 level was significantly lower in obese children with NAFLD compared with other two groups(P<0.05). After adjusted for age and waist circumference, omentin-1 was negatively correlated with NAFLD,low-density lipoprotein level(LDL-C) and leptin/adiponectin (LAR), and was positively correlated with adiponectin (all P<0.05). Furthermore, Logistics regression analysis showed BMI, HOMA-IR were risk factors for NAFLD, and omentin-1 was a protected factor (P<0.05). BMI, waist circumference and omentin-1 were helpful for NAFLD diagnosis. Conclusion Serum omentin-1 is related to childhood body lipid especially central obesity,lipid disorder and NAFLD, which may be a beneficial adiposity factor helpful to improve childhood NAFLD.
关键词
网膜素-1 /
非酒精性脂肪肝 /
脂肪因子 /
儿童
Key words
omentin-1 /
non-alcoholic fatty liver disease /
adipokine /
children
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基金
国家自然科学基金(81172689);陕西省社会发展科技攻关项目(2016SF-210);西安交通大学第二附属医院重大科研方向资助计划{[Y](ZDJH)201303}。
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