牙釉质中的蛋白质基因与儿童龋病相关性的研究

刘琼; 钱虹

doi:10.11852/zgetbjzz2018-26-08-14

PDF(384 KB)

中国儿童保健杂志 ›› 2018, Vol. 26 ›› Issue (8) : 862-864. DOI: 10.11852/zgetbjzz2018-26-08-14

综述与讲座

牙釉质中的蛋白质基因与儿童龋病相关性的研究

刘琼, 钱虹

作者信息 +

Research progress on the correlation between protein gene in enamel and dental caries in children

LIU Qiong,QIAN Hong

Author information +

文章历史 +

摘要

龋病在儿童中最为常见,由于儿童龋病不会自行修复,且发展下去会引起局部疼痛、脓肿,导致咀嚼困难、睡眠困难,甚至会影响儿童的生长发育。引起龋病的原因有很多:细菌、不健康饮食、不良的口腔卫生习惯等。近年来越来越多的学者发现龋病的发生与宿主的易感性关系密切,研究热点主要为牙釉质中的相关蛋白质。本文就牙釉质中蛋白质基因的多态性和儿童龋病的发生是否具有相关性的研究进展作一综述。

Abstract

Caries are the most common disease in children.Dental caries in children are not self-healing, and if the disease develops, they will cause local pain and abscess, thereby resulting in chewing difficulties, sleep difficulties, and even affecting children′s growth.There are many causes of caries:bacteria, unhealthy diets, poor oral hygiene habits and so on.Recently, more and more scholars have found that the occurrence of caries is closely related to the susceptibility of host, and researches mainly focus on the protein in enamel.This article reviews the progress on the correlation of polymorphism of protein gene in enamel with the occurrence of children dental caries.

导出引用

刘琼, 钱虹. 牙釉质中的蛋白质基因与儿童龋病相关性的研究[J]. 中国儿童保健杂志. 2018, 26(8): 862-864 https://doi.org/10.11852/zgetbjzz2018-26-08-14

LIU Qiong,QIAN Hong. Research progress on the correlation between protein gene in enamel and dental caries in children[J]. Chinese Journal of Child Health Care. 2018, 26(8): 862-864 https://doi.org/10.11852/zgetbjzz2018-26-08-14

中图分类号： R179

参考文献

[1] Lawrence D,Robertson,Ananda,et al.A novel staging system for caries severity in the primary dentition[J].J Public Health Dent,2016,77(1):6-12.
[2] 吴玮,邱荣敏,曾晓娟.南宁市 3～5岁儿童乳牙局部用氟防龋效果分析[J].口腔疾病防治,2016,24(5):310-313.
[3] 李菊红,阮世红,张紫阳.深圳市小学生恒牙龋病的流行病学分析[J].口腔疾病防治,2017,25(1):52-54.
[4] Anil S,Anand PS.Early childhood caries:prevalence,risk factors,and prevention[J].Front Pediatr,2017,5(157):1-7.
[5] Vieira AR,Modesto A,Marazita ML.Caries:review of human genetics research[J].Caries Res,2014,48 (5):491-506.
[6] Bretz WA,Corby PM,Schork NJ,et al.Longitudinal analysis of heritability for dental caries traits[J].J Dent Res,2015,84(11):1047-1051.
[7] Greene SR,Yuan ZA,Wright JT,et al.A new frameshift mutation encoding a truncated amelogenin leads to x-linked amelogenesis imperfecta[J].Arch Oral Biol,2002,47(3):211-217.
[8] 于世凤.口腔组织病理学[M].北京:人民卫生出版社,2004.
[9] Lakshminarayanan R,Fan D,Du C,et al.The role of secondary structure in the entropically driven amelogenin self-assembly[J].Biophys J,2007,93(10):3664-3674.
[10] Wen HB,Moradian-Oldak J.Modification of calcium-phosphate coatings on titanium by recombinant amelogenin[J].J Biomed Mater Res A,2003,64(3):483-490.
[11] Moradianoldak J.Protein-mediated enamel mineralization[J].Front Biosci,2012,17 (6):1996.
[12] Kang SW,Yoon I,Lee HW,et al.Association between AMELX polymorphisms and dental[J].Oral Dis,2011,17(4):399-406.
[13] Deeley K,Letra A,Rose EK,et al.Possible association of amelogenin to high caries:experience in a Guatemalan-Mayan population[J].Caries Res,2008,42(1):8-13.
[14] Antunes LA,Antunes LS,Kuchler Ec,et al.Analysis of the association between polymorphisms in MMP2, MMP3, MMP9, MMP20, TIMP1, and TIMP2 genes with white spot lesions and early childhood caries[J].Int J Paediatri Dent,2016,26(4):310-319.
[15] Shimizu T,Ho B,Deeley K,et al.Enamel formation genes influence enamel micohardness before and after cariogenic challenge[J].PLoS One,2012,7(9):e45022.
[16] Patir A,Seymen F,Yildirim M,et al.Enamel formation genes are associated with high caries experience in Turkish children[J].Caries Res,2008,42(5):394-400.
[17] 邹慧儒,秦宗长.釉基质蛋白各组成成分及其作用[J].国际口腔医学杂志,2013,40(3):355-358.
[18] Yamakoshi Y,Tanabe T,Oida S,et al.Calcium binding of enamel proteins and their derivatives with emphasis on the calcium-binding domain of porcine sheathlin[J].Arch Oral Biol,2001,46 (11):1005-1014.
[19] Olszowski T,Adler G,Janiszewska-Olszowska J,et al.MBL2,MASP2,AMELX,and ENAM gene polymorphisms and dental caries in Polish children[J].Oral Dis,2012,18(4):389-395.
[20] Gerreth K,Zaorska K,ZabeL M,et al.Association of ENAM gene single nucleotide polymorphisms with dental caries in Polish children[J].Clin Oral Investig,2016,20(3):631-636.
[21] Chaussain C,Bouazza N,Gasse B,et al.Dental caries and enamelin haplotype[J].J Dent Res,2014,93(4):360-365.
[22] Slayton RL,Cooper ME,Marazita ML.Tuftelin, mutans streptococci,and dental caries susceptibility[J].J Dent Res,2005,84 (8):711-714.
[23] Lu Y,Papagerakis P,Yamakoshi Y,et al.Functions of KLK4 and MMP-20 in dental enamel formation[J].Biol Chem,2008,389(6):695-700.
[24] 吕燕,苗治晶,丁虹娟.基质金属蛋白酶在产科领域的研究进展[J].医学综述,2017,23(20):3958-3962.
[25] 付廷刚,张静,韩婷婷.基质金属蛋白酶-20的研究进展[J].解剖科学进展,2011,17(4):402-404.
[26] 王光平,李明霞,刘建国.激肽释放酶4与釉质发生不全[J].国际口腔医学杂志,2013,40(4):537-539.
[27] Tannure PN,Kuchler EC,Falagan-Lotsch P,et al.MMP13 polymorphism decreases risk for dental caries[J].Caries Res,2012,46(4):401-407.
[28] Tannure PN,Kuchler EC,Lips A,et al.Genetic variation in MMP20 contributes to higher caries experience[J].J Dent,2012,40(5):381-386.
[29] Shahid M,Balto HA,Al-Hammad N,et al.Mutations in MSX1, PAX9 and MMP20 genes in Saudi Arabian patients with tooth agenesis[J].Eur J Med Genet,2016,59(8):377-385.
[30] Abbasoglu Z,Tanboga I,Erika C.Early childhood caries is associated with genetic variants in enamel formation and immune response genes[J].Caries Res,2015,49(1):70-77.
[31] 高祯,蔡蔚,霍东婷,等.氟保护漆预防学龄前儿童乳牙龋的疗效观察[J].中国儿童保健杂志,2017,25(5):519-522.