孤独谱系障碍患者大尺度脑网络功能连接改变的研究进展

赵力聪 综述; 杜亚松 审校

doi:10.11852/zgetbjzz2018-26-07-14

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中国儿童保健杂志 ›› 2018, Vol. 26 ›› Issue (7) : 748-750. DOI: 10.11852/zgetbjzz2018-26-07-14

综述与讲座

孤独谱系障碍患者大尺度脑网络功能连接改变的研究进展

赵力聪综述, 杜亚松审校

作者信息 +

Research progress on the changes in large-scale brain network in autism

ZHAO Li-cong, DU Ya-song

Author information +

文章历史 +

摘要

静息态功能磁共振成像作为非侵入性且可视化成像方法,数据采集简便易行,已成为探索孤独谱系障碍(ASD)患者脑功能变化的主要成像手段。目前认为大尺度脑网络的模式提供了一种新的方式,可以进一步了解包括ASD在内的神经精神疾病的脑网络异常。本文对ASD患者核心脑网络功能连接的变化及其与症状的关系进行综述。

Abstract

Resting-state magnetic resonance imaging,as a non-invasive and visual method,has been one of the most important techniques for autism brain function analysis.Currently,the model of large-scale brain network provides a new approach to understand the abnormality of neuropsychiatric disorder including autism spectrum disorder (ASD).This review summarizes the change in connectivity of the core brain network of autism and its relationship with the symptoms.

导出引用

赵力聪综述, 杜亚松审校. 孤独谱系障碍患者大尺度脑网络功能连接改变的研究进展[J]. 中国儿童保健杂志. 2018, 26(7): 748-750 https://doi.org/10.11852/zgetbjzz2018-26-07-14

ZHAO Li-cong, DU Ya-song. Research progress on the changes in large-scale brain network in autism[J]. Chinese Journal of Child Health Care. 2018, 26(7): 748-750 https://doi.org/10.11852/zgetbjzz2018-26-07-14

中图分类号： R179

参考文献

[1] Bos DJ,Raalten TRV,Oranje B,et al.Developmental differences in higher-order resting-state networks in autism spectrum disorder[J].Neuroimage Clinical,2014,4:820-827.
[2] Zielinski BA,Anderson JS,Froehlich AL,et al.scMRI reveals large-scale brain network abnormalities in autism[J].PLoS ONE,2012,7(11):e49172.
[3] Nomi JS,Uddin LQ.Developmental changes in large-scale network connectivity in autism[J].Neuroimage Clinical,2015,7:732-741.
[4] Just MA,Cherkassky VL,Keller TA,et al.Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity[J].Brain,2004,127(8):1811-1821.
[5] Martino AD,Yan CG,Li Q,et al.The autism brain imaging data exchange: towards large-scale evaluation of the Intrinsic brain architecture in autism[J].Molecular Psychiatry,2014,19(6):659-667.
[6] Bressler SL,Menon V.Large-scale brain networks in cognition: emerging methods and principles[J].Trends in Cognitive Sciences,2010,14(6):277-290.
[7] Green SA,Hernandez L,Bookheimer SY,et al.Salience network connectivity in autism is related to brain and behavioral markers of sensory overresponsivity[J].J Am Acad Child Adoless Psychiatry,2016,55(7):618-626.
[8] Schiff ND,Rodriguez-Moreno D,Kamal A,et al.fMRI reveals large-scale network activation in minimally conscious patients.[J].Neurology,2005,64(3):514-523.
[9] Damoiseaux JS,Rombouts SARB,Barkhof F,et al.Consistent resting-state networks across healthy subjects[J].Proc Natl Acad Sci USA,2006,103(37):13848-13853.
[10] Fox MD,Snyder AZ,Vincent JL,et al.The human brain is intrinsically organized into dynamic,anticorrelated functional networks[J].Proc Natl Acad Sci USA,2005,102(27):9673-9678.
[11] Hilgetag CC,Goulas A.Is the brain really a small-world network?[J].Brain Struct Funct,2016,221(4):2361-2366.
[12] Wang Z,Dai Z,Gong G,et al.Understanding structural-functional relationships in the human brain: a large-scale network perspective[J].Neuroscientist,2015,21(3):290-305.
[13] Achard S,Salvador R,Whitcher B,et al.A resilient,low-frequency,small-world human brain functional network with highly connected association cortical hubs[J].J Neurosci NLM,2006,26(1):63-72.
[14] Funakoshi Y,Harada M,Otsuka H,et al.Default mode network abnormalities in children with autism spectrum disorder detected by resting-state functional magnetic resonance imaging[J].J Med Invest,2016,63(3-4):204-208.
[15] Lynch CJ,Uddin LQ,Supekar K,et al.Default mode network in childhood autism: posteromedial cortex heterogeneity and relationship with social deficits[J].Biol Psychiatry,2013,74:212-219.
[16] Uddin LQ.Salience processing and insular cortical function and dysfunction[J].Nat Rev Neurosci,2015,16(1):55-61.
[17] Toyomaki A,Murohashi H.“Salience network” dysfunction hypothesis in autism spectrum disorders[J].Jpn Psychol Research,2013,55(2):175-185.
[18] Ea VDH,Stoyanova RS,Baroncohen S,et al.Reduced functional connectivity within and between 'social' resting state networks in autism spectrum conditions[J].Soc Cogn Aflect Neurosci,2012,8(6):694-701.
[19] Uddin LQ,Supekar K,Lynch CJ,et al.Salience network-based classification and prediction of symptom severity in children with autism[J].Jama Psychiatry,2013,70(8):869-879.
[20] Farrant K,Uddin LQ.Asymmetric development of dorsal and ventral attention networks inthe human brain[J].Dev Cogn Neuros-NETH,2015,12(2):165-174.
[21] Farrant K,Uddin LQ.Atypical developmental of dorsal and ventral attention networks in autism[J].Dev Sci,2016,19(4):550-563.
[22] Keehn B,Müller RA,Townsend J.Atypical attentional networks and the emergence of autism[J].Neurosci Biobehav R,2013,37(2):164-183.
[23] Kana RK,Liu Y,Williams DL,et al.The local,global,and neural aspects of visuospatial processing in autism spectrum disorders[J].Neuropsychologia,2013,51(14):2995-3003.
[24] Abbott AE,Nair A,Keown CL,et al.Patterns of atypical functional connectivity and behavioral links in autism differ fetween default,salience,and executive,networks[J].Cerebral Cortex,2016,10:4034-4045.